PDF(Pubmed)
Abstract：
UNASSIGNED: With the increased use of cannabis in the US, there is a significant need to understand the medical complications associated with its use in relationship to a surgical population. Cannabis has mainly been studied with respect to its qualities of pain treatment, yet few studies have investigated post-surgical complications associated with its use. Therefore, the purpose of this study was to explore the effect of cannabis use on complications in spine surgery, and compare these complications rates to opioid-related complications.
UNASSIGNED: This was a retrospective study conducted using the PearlDiver Database. Using ICD codes 40,989 patients that underwent lumbar spine fusion between January 2010 and October 2020 were identified and divided into 3 study groups (i.e., control, patients with known opioid use disorder, and patients identified as cannabis users). Differences in the incidence of complications within 30 days of the index procedure and pseudarthrosis rates at 18 months postindex procedure were assessed among study groups using a multivariate logistic regression.
UNASSIGNED: Of 12.4% study population used cannabis and 38.8% had a known opioid use disorder. Results indicated increased odds of experiencing a VTE, hypoxia, myocardial infarction, and arrhythmia for both opioid and cannabis users compared to controls; however, when controlling for tobacco use there were no increased odds of complications within the cannabis group. The pseudarthrosis rate was greater in cannabis users (2.4%) than in controls (1.1%).
UNASSIGNED: The pseudarthrosis rate was significantly greater in patients using cannabis and opioids compared to the control group. However, when controlling for tobacco use, results suggested a possible negative synergistic between cannabis use and concomitant tobacco use that may influence bone fusion.
UNASSIGNED: This was a retrospective study conducted using the PearlDiver Database. Using ICD codes 40,989 patients that underwent lumbar spine fusion between January 2010 and October 2020 were identified and divided into 3 study groups (i.e., control, patients with known opioid use disorder, and patients identified as cannabis users). Differences in the incidence of complications within 30 days of the index procedure and pseudarthrosis rates at 18 months postindex procedure were assessed among study groups using a multivariate logistic regression.
UNASSIGNED: Of 12.4% study population used cannabis and 38.8% had a known opioid use disorder. Results indicated increased odds of experiencing a VTE, hypoxia, myocardial infarction, and arrhythmia for both opioid and cannabis users compared to controls; however, when controlling for tobacco use there were no increased odds of complications within the cannabis group. The pseudarthrosis rate was greater in cannabis users (2.4%) than in controls (1.1%).
UNASSIGNED: The pseudarthrosis rate was significantly greater in patients using cannabis and opioids compared to the control group. However, when controlling for tobacco use, results suggested a possible negative synergistic between cannabis use and concomitant tobacco use that may influence bone fusion.
摘要：
■随着美国大麻使用的增加，非常需要了解与其使用相关的医疗并发症与手术人群的关系.主要研究了大麻的疼痛治疗质量，然而，很少有研究调查与使用它相关的术后并发症。因此,这项研究的目的是探讨使用大麻对脊柱手术并发症的影响，并将这些并发症发生率与阿片类药物相关并发症进行比较。
■这是一项使用PearlDiver数据库进行的回顾性研究。使用ICD代码，确定了2010年1月至2020年10月期间接受腰椎融合的40,989例患者，并将其分为3个研究组（即，control,已知阿片类药物使用障碍的患者，和被确定为大麻使用者的患者)。使用多变量逻辑回归评估了研究组之间在指数程序后30天内的并发症发生率和在指数程序后18个月的假关节发生率的差异。
■12.4%的研究人群使用大麻，38.8%的人患有已知的阿片类药物使用障碍。结果表明经历VTE的几率增加，缺氧,心肌梗塞,与对照组相比，阿片类药物和大麻使用者的心律失常；然而，在控制烟草使用时,大麻组出现并发症的几率没有增加.大麻使用者的假关节发生率（2.4％）高于对照组（1.1％）。
■使用大麻和阿片类药物的患者的假关节发生率明显高于对照组。然而,在控制烟草使用时，结果表明，大麻使用和伴随烟草使用之间可能存在负协同作用，这可能会影响骨融合。
■这是一项使用PearlDiver数据库进行的回顾性研究。使用ICD代码，确定了2010年1月至2020年10月期间接受腰椎融合的40,989例患者，并将其分为3个研究组（即，control,已知阿片类药物使用障碍的患者，和被确定为大麻使用者的患者)。使用多变量逻辑回归评估了研究组之间在指数程序后30天内的并发症发生率和在指数程序后18个月的假关节发生率的差异。
■12.4%的研究人群使用大麻，38.8%的人患有已知的阿片类药物使用障碍。结果表明经历VTE的几率增加，缺氧,心肌梗塞,与对照组相比，阿片类药物和大麻使用者的心律失常；然而，在控制烟草使用时,大麻组出现并发症的几率没有增加.大麻使用者的假关节发生率（2.4％）高于对照组（1.1％）。
■使用大麻和阿片类药物的患者的假关节发生率明显高于对照组。然而,在控制烟草使用时，结果表明，大麻使用和伴随烟草使用之间可能存在负协同作用，这可能会影响骨融合。
