patterning

图案化
  • 文章类型: Journal Article
    像素化的红色图案,绿色,蓝色量子点(QD)是实现具有明亮生动图像的高端显示器的关键挑战,增强,混合现实由于QD必须从溶液中处理,它们的图案化工艺与OLED和LCD行业中使用的常规技术完全不同。尽管正在开发创新的QD图案化技术,基于QD膜的光诱导化学转化的光图案化被认为是形成满足商业化所需的精度和保真度的微米级QD图案的最有前途的方法之一。此外,实际影响将是巨大的,因为它直接利用半导体行业广泛可用的成熟光刻技术和设施。本文综述了通过光刻形成QD图案的最新进展。该综述从光刻工艺的一般描述开始。随后,介绍了适用于QD图案化的不同类型的光刻方法,随后是使用这些方法形成高分辨率QD模式的最新成就。并对未来的研究方向进行了展望。本文受版权保护。保留所有权利。
    Pixelating patterns of red, green, and blue quantum dots (QDs) is a critical challenge for realizing high-end displays with bright and vivid images for virtual, augmented, and mixed reality. Since QDs must be processed from a solution, their patterning process is completely different from the conventional techniques used in the organic light-emitting diode and liquid crystal display industries. Although innovative QD patterning technologies are being developed, photopatterning based on the light-induced chemical conversion of QD films is considered one of the most promising methods for forming micrometer-scale QD patterns that satisfy the precision and fidelity required for commercialization. Moreover, the practical impact will be significant as it directly exploits mature photolithography technologies and facilities that are widely available in the semiconductor industry. This article reviews recent progress in the effort to form QD patterns via photolithography. The review begins with a general description of the photolithography process. Subsequently, different types of photolithographical methods applicable to QD patterning are introduced, followed by recent achievements using these methods in forming high-resolution QD patterns. The paper also discusses prospects for future research directions.
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  • 文章类型: Journal Article
    已经提出了开发用于牙周组织再生的工程支架的不同方法。在这次审查中,根据临床前体内研究和临床试验的结果,对干细胞技术和支架工程的创新主要集中在牙周膜(PDL)再生上进行了讨论和分析。大多数这些发展包括使用具有不同图案和表面纳米形貌的聚合物材料,以及印刷具有不同隔室的复杂和复杂的多相复合支架,以适应不同的牙周组织结构。尽管在生产这些支架方面付出了更多的努力,并且它们在引导和支持组织再生方面的效率毋庸置疑,还需要适当的细胞来源以提供新的组织形成和来自胞外基质(ECM)的各种生物和机械化学线索,从而为细胞生长和分化提供生物物理刺激。细胞片工程是一种新颖的有前途的技术,可以在保留ECM成分的同时获得片状形式的细胞。尚未发现这些因素的正确组合,仍然需要努力改善发育组织的功能组织的再生结果。
    Different approaches to develop engineered scaffolds for periodontal tissues regeneration have been proposed. In this review, innovations in stem cell technology and scaffolds engineering focused primarily on Periodontal Ligament (PDL) regeneration are discussed and analyzed based on results from pre-clinical in vivo studies and clinical trials. Most of those developments include the use of polymeric materials with different patterning and surface nanotopography and printing of complex and sophisticated multiphasic composite scaffolds with different compartments to accomodate for the different periodontal tissues\' architecture. Despite the increased effort in producing these scaffolds and their undoubtable efficiency to guide and support tissue regeneration, appropriate source of cells is also needed to provide new tissue formation and various biological and mechanochemical cues from the Extraccellular Matrix (ECM) to provide biophysical stimuli for cell growth and differentiation. Cell sheet engineering is a novel promising technique that allows obtaining cells in a sheet format while preserving ECM components. The right combination of those factors has not been discovered yet and efforts are still needed to ameliorate regenerative outcomes towards the functional organisation of the developed tissues.
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  • 文章类型: Journal Article
    薄膜复合(TFC)膜是用于低成本和高能效水脱盐工艺的最广泛使用的膜。正确控制三个有影响的表面参数,即润湿性,粗糙度,和表面电荷,在优化TFC膜表面和渗透性能方面至关重要。更具体地说,TFC膜的表面性质通常通过掺入新型特殊润湿性材料来调整以增加亲水性和调节表面物理化学异质性。这些基本参数影响膜的渗透性和防污性能。迄今为止采用的膜表面表征方案相当有争议,并且对于用于评估表面亲水性和物理化学异质性的指标没有普遍的共识。在这次审查中,我们调查并严格评估了使用简单而经济的接触角分析技术来了解膜表面特性的过程。接触角分析允许估计表面润湿性,表面自由能,表面电荷,疏油性,接触角滞后,和相互作用的自由能;所有这些都协调地影响膜的渗透和污染特性。这篇综述将提供通过接触角分析简化膜性能评估的见解,这将最终通过减少表征所需的时间和费用来加快膜开发过程,以确认任何修改的成功和影响。
    Thin-film composite (TFC) membranes are the most widely used membranes for low-cost and energy-efficient water desalination processes. Proper control over the three influential surface parameters, namely wettability, roughness, and surface charge, is vital in optimizing the TFC membrane surface and permeation properties. More specifically, the surface properties of TFC membranes are often tailored by incorporating novel special wettability materials to increase hydrophilicity and tune surface physicochemical heterogeneity. These essential parameters affect the membrane permeability and antifouling properties. The membrane surface characterization protocols employed to date are rather controversial, and there is no general agreement about the metrics used to evaluate the surface hydrophilicity and physicochemical heterogeneity. In this review, we surveyed and critically evaluated the process that emerged for understanding the membrane surface properties using the simple and economical contact angle analysis technique. Contact angle analysis allows the estimation of surface wettability, surface free energy, surface charge, oleophobicity, contact angle hysteresis, and free energy of interaction; all coordinatively influence the membrane permeation and fouling properties. This review will provide insights into simplifying the evaluation of membrane properties by contact angle analysis that will ultimately expedite the membrane development process by reducing the time and expenses required for the characterization to confirm the success and the impact of any modification.
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  • 文章类型: Journal Article
    本综述将介绍丝基电子/光电子的基本概念,包括丝素蛋白与其他功能成分结合使用的最新技术进展,重点是提高下一代丝基材料的性能。它还突出了丝素蛋白的图案,以产生微/纳米级特征,以及丝素蛋白的官能化以赋予抗微生物(即抗菌)性质。基于丝绸的生物电子学在先进或未来的生物应用中具有巨大的潜力,包括电子皮肤,电子绷带,生物传感器,可穿戴显示器,可植入装置,人造肌肉,等。值得注意的是,基于丝的有机场效应晶体管在电子皮肤和生物传感器中具有非常有前途的应用;基于丝的电极/天线用于体内生物分析或传感目的(例如,测量神经递质,如多巴胺)除了用作食物传感器外;基于丝的二极管可用作伤口愈合或组织工程的光源,例如,在皮肤伤口闭合或诱导角膜新生血管的光血栓形成中;基于丝的执行器具有作为人造肌肉的有希望的应用;而基于丝的忆阻器具有作为逻辑或突触网络的令人兴奋的应用,用于实现电子皮肤或仿生大脑。
    The present review will introduce the basic concepts of silk-based electronics/optoelectronics including the latest technological advances on the use of silk fibroin in combination with other functional components, with an emphasis on improving the performance of next-generation silk-based materials. It also highlights the patterning of silk fibroin to produce micro/nano-scale features, as well as the functionalization of silk fibroin to impart antimicrobial (i.e. antibacterial) properties. Silk-based bioelectronics have great potential for advanced or futuristic bio-applications including e-skins, e-bandages, biosensors, wearable displays, implantable devices, artificial muscles, etc. Notably, silk-based organic field-effect transistors have highly promising applications in e-skins and biosensors; silk-based electrodes/antennas are used for in vivo bioanalysis or sensing purpose (e.g., measurement of neurotransmitter such as dopamine) in addition to their use as food sensors; silk-based diodes can be applied as light sources for wound healing or tissue engineering, e.g., in cutaneous wound closure or induction of photothrombosis of corneal neovascularization; silk-based actuators have promising applications as artificial muscles; whereas silk-based memristors have exciting applications as logic or synaptic network for realizing e-skins or bionic brains.
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    文章类型: Journal Article
    背景:水平凝视麻痹伴进行性脊柱侧弯综合征(HGPPS)是一种罕见的人类疾病,尽管其与脊柱侧弯的关联于1974年首次报道,但三十年后,相关的基因突变正在被阐明。这一进展是由于报告了单个有趣的案例。
    方法:我们介绍了一名27岁的男性患者的病例,该患者因选择性脊柱侧凸矫正手术入院,并因头痛和呕吐而出院。由于凝视麻痹,他接受了脑部成像,证实了脑干异常。与水平凝视麻痹伴进行性脊柱侧凸(HGPPS)综合征一致,一种罕见的常染色体隐性疾病。
    结论:这种罕见的综合征是一个很好的例子,说明单个病例报告如何导致实验室研究和疾病遗传特征的进步,以及对神经发育的影响。在非神经系统脊柱侧凸的神经系统检查中保持警惕将有助于识别潜在的此类病例,而进一步的遗传/分子分析可能会进一步揭示神经胚胎发育和模式。
    BACKGROUND: The syndrome of horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare human disease and while its association with scoliosis was first reported in 1974, thirty years later the responsible genetic mutations are being elucidated. This progress was due to the reporting of single interesting cases.
    METHODS: We present the case of a 27 year-old male patient who was admitted for elective scoliosis correction surgery and who represented after an uncomplicated discharge with headache and vomiting; because of a gaze palsy he underwent brain imaging that confirmed a brainstem abnormality, consistent with the syndrome of horizontal gaze palsy with progressive scoliosis (HGPPS), a rare autosomal recessive human disease.
    CONCLUSIONS: This rare syndrome is a good example of how single case reports can lead to advances in laboratory research and genetic characterisation of diseases, together with implications for neurodevelopment. Vigilance in the neurological examination in an otherwise \'non-neurological\' scoliosis will help identify potential such cases, whilst further genetic/molecular analysis may shed further light into neuro-embryological development and patterning.
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