背景:肥胖是一种全球流行病,是全球慢性肾病的主要原因。这项干预研究旨在评估独特的欧芹种子面包和健康均衡饮食对肥胖女性血清骨桥蛋白水平和肾功能的影响。
方法:共有85名肥胖女性(BMI,35.68±0.47kg/m2)参加了为期8周的营养干预,包括两个阶段。在第一阶段,参与者食用100克欧芹籽面包以及健康均衡的低热量方案4周。在第二阶段,Baladi面包代替了补充剂,提供相等的热量摄入,再过四个星期.相关人体测量,血压,饮食召回,和生化参数(骨桥蛋白,IL-1β,IL-10,肾功能,和脂质参数)在每个干预阶段之前和之后进行评估。
结果:在初始干预阶段之后,所有记录的平均人体测量参数均有显著改善(p≤0.001).血脂参数和危险因素也显著降低(p<0.05),而骨桥蛋白,肌酐,IL-1β水平明显下降。eGFR,肌酐清除率,IL-10增加。然而,在第二阶段省略补充剂后,这些改善的值恢复到升高的水平。骨桥蛋白与肌酐呈显著负相关,肌酐清除率,IL-10
结论:基于欧芹种子的新型干预措施和健康平衡的低热量治疗方案的联合作用证明了与肾脏疾病相关的骨桥蛋白水平的改善,和炎症,除了肥胖女性的血脂异常。这表明了改善和保护肾脏疾病的有希望的方法。
Obesity is a global epidemic and a major contributor to chronic kidney disease worldwide. This interventional
study aimed to evaluate the effects of a unique parsley seed bread and a healthy balanced diet on serum
osteopontin level and renal function in obese women.
A total of 85 obese women (BMI, 35.68 ± 0.47 kg/m2) participated in an 8-week nutritional intervention comprising two phases. In the first phase, participants consumed 100 g of ground parsley seed bread along with a healthy balanced low caloric regimen for four weeks. In the second phase, Baladi bread was substituted for the supplement, providing an equal caloric intake, for another four weeks. Relevant Anthropometric measurements, blood pressure, dietary recall, and biochemical parameters (
osteopontin, IL-1β, IL-10, kidney functions, and lipid parameters) were assessed before and after each intervention phase.
Following the initial intervention phase, there were significant improvements in all recorded mean anthropometric parameters (p ≤ 0.001). Lipid parameters and risk factors also significantly decreased (p < 0.05), while
osteopontin, creatinine, and IL-1β levels decreased significantly. eGFR, creatinine clearance, IL-10 increased. However, these improved values returned to elevated levels after the omission of the supplement in the second phase. There was a significant negative correlation between
osteopontin and creatinine, creatinine clearance, and IL-10.
The combined effect of the novel parsley seed-based intervention and a healthy balanced low-calorie regimen demonstrated improvements in osteopontin level associated with renal disorders, and inflammation, in addition to dyslipidemia in obese women. This suggests a promising approach for improving and protecting kidney disorders.