孟德尔随机化(MR)分析用于确定2型糖尿病(T2D)和骨髓炎(OM)之间的因果关系。我们使用来自不同大规模全基因组关联研究(GWAS)的合并数据进行了MR分析。仪器变量是根据全基因组显著性选择的,仪器强度用F值评估,通过Bonferroni校正进一步调整了暴露表型数量的阈值。我们进行了单变量和多变量MR分析,以评估由T2D介导的因果效应和比例.IVW(方差反加权)显示骨髓炎对以下方面的显着遗传影响:Bonferroni校正后,单变量分析表明,儿童体重指数(BMI)与OM[比值比(OR),1.26;95%置信区间(CI),1.02,1.55;P=.030],与成年期BMI(OR,1.28;95%CI,1.02,1.61;P=0.034),与腰围显著相关(OR,1.84;95%CI,1.51,2.24;P<.001),并与臀围显著相关(OR,1.52;95%CI,1.31,1.76;P<.001)。同时,多变量分析显示儿童BMI对OM没有显著影响(OR,1.16;95%CI,0.84,1.62;P=.370),成年BMI对OM(OR,0.42;95%CI,0.21,0.84;P=0.015),腰围和OM(OR,4.30;95%CI,1.89,9.82;P=.001),T2D介导10%(95%CI,0.02,0.14),臀围与OM无显著关联(OR,1.01;95%CI,0.54,1.90;P=.968)。我们的研究提供了肥胖之间遗传预测因果关系的证据,T2D,和OM。我们证明,腰围增加与OM风险增加呈正相关,而T2D介导了这种关系。临床医生在肥胖T2D患者骨髓炎手术的围手术期处理中应更加谨慎。此外,与其他肥胖措施相比,腰围可能是更重要的强调和严格控制标准。
Mendelian randomization (MR) analysis was used to determine the causal relationship between Type 2 diabetes (T2D) and
osteomyelitis (OM). We performed MR analysis using pooled data from different large-scale genome-wide association studies (GWAS). Instrumental variables were selected based on genome-wide significance, instrumental strength was assessed using F-values, and thresholds for the number of exposed phenotypes were further adjusted by Bonferroni correction. univariable and multivariable MR analyses were performed to assess causal effects and proportions mediated by T2D. IVW (inverse variance weighting) showed a significant genetic effect of
osteomyelitis on the following: After correction by Bonferroni, univariable analyses showed that childhood body mass index (BMI) was not significantly associated with genetic susceptibility to OM [odds ratio (OR), 1.26; 95% confidence interval (CI), 1.02, 1.55; P = .030], not significantly associated with adulthood BMI (OR, 1.28; 95% CI, 1.02, 1.61; P = .034), significantly associated with waist circumference (OR, 1.84; 95% CI, 1.51, 2.24; P < .001), and significantly associated with hip circumference (OR, 1.52; 95% CI, 1.31, 1.76; P < .001). Meanwhile, multivariable analyses showed no significant effect of childhood BMI on OM (OR, 1.16; 95% CI, 0.84, 1.62; P = .370), no significant effect of adulthood BMI on OM (OR, 0.42; 95% CI, 0.21, 0.84; P = .015), a significant association between waist circumference and OM (OR, 4.30; 95% CI, 1.89, 9.82; P = .001), T2D mediated 10% (95% CI, 0.02, 0.14), and no significant association between hip circumference and OM (OR, 1.01; 95% CI, 0.54, 1.90; P = .968). Our
study provides evidence for a genetically predicted causal relationship among obesity, T2D, and OM. We demonstrate that increased waist circumference is positively associated with an increased risk of OM and that T2D mediates this relationship. Clinicians should be more cautious in the perioperative management of
osteomyelitis surgery in obese patients with T2D. In addition, waist circumference may be a more important criterion to emphasize and strictly control than other measures of obesity.