METHODS: A retrospective multicenter study was conducted on neonates (0-28 days old, n = 94) and infants (1-12 months old, n = 415) with osteoarticular infections. Data consisting of clinical characteristics, complications, laboratory outcomes, and the pathogenic microorganisms causing osteomyelitis were tabulated. The statistics were further broken down into two regions and the significant differences between neonates and infants were evaluated and compared to the literature.
RESULTS: Compared to infants, neonates had significantly lower incidences of fever (p < 0.0001), higher incidences of localized swelling (p = 0.0021), higher rate of infection at the humerus (p = 0.0016), higher percentage of Escherichia coli (p < 0.0001) and Klebsiella pneumoniae (p = 0.0039) infections, lower percentage of Staphylococcus aureus infections (p < 0.0001) and were more likely to develop septic arthritis (p < 0.0001).
CONCLUSIONS: Distinct differences were found between neonatal and infants with osteoarticular infections. Future studies should focus on improving diagnosis and subsequent treatment regimens for younger age groups.
方法:对新生儿(0-28日龄,n=94)和婴儿(1-12个月大,n=415)伴有骨关节感染。由临床特征组成的数据,并发症,实验室结果,列出了引起骨髓炎的病原微生物。将统计数据进一步细分为两个区域,并评估新生儿和婴儿之间的显着差异,并与文献进行比较。
结果:与婴儿相比,新生儿发热发生率明显较低(p<0.0001),局部肿胀发生率较高(p=0.0021),肱骨感染率较高(p=0.0016),大肠杆菌(p<0.0001)和肺炎克雷伯菌(p=0.0039)感染的百分比更高,金黄色葡萄球菌感染的比例较低(p<0.0001),并且更可能发生化脓性关节炎(p<0.0001).
结论:在患有骨关节感染的新生儿和婴儿之间发现了明显的差异。未来的研究应侧重于改善年轻年龄组的诊断和后续治疗方案。