海马振荡经常被描述为在啮齿动物的空间记忆和导航中起主导作用。在人类中,在导航记忆过程中,前后节律的相对作用尚未确定。
这里,我们使用患者前海马和后海马的直接脑ECoG记录来检验这一假设,在需要空间记忆的导航任务中。我们在编码和检索阶段评估了多个振荡带。
我们在检索过程中发现了与导航相关的1-3.5Hz活动,海马前后都有.在编码和检索期间,识别出4到8Hz之间的活动,只在前海马区.
我们的发现与海马中存在前/后功能梯度的观点一致,涉及两个不同的神经元网络,支持编码或检索过程。虽然这是一个单一的情况下,这些发现表明,空间导航过程中的神经振荡确实在海马亚区有所不同,作为记忆过程中编码与检索过程的函数。在这个单一案例研究中,结果表明,在编码和检索过程中,海马亚区的多个频带存在双重参与.虽然这些结果需要推广,它们为人类在编码和检索过程中的空间导航中前后海马的不同生理特性提供了新的视角。
Hippocampal
oscillations have been regularly described as playing a dominant role in spatial memory and navigation in rodents. In humans, the relative role of anterior versus posterior rhythms during navigational memory is not established.
Here, we tested this hypothesis using direct brain ECoG recordings in the anterior and posterior hippocampus of a patient, in a navigational task requiring spatial memory. We assessed multiple oscillatory bands during encoding and retrieval phases.
We found navigation related 1-3.5 Hz activity during retrieval, both in the anterior and posterior hippocampus. Activity between 4 and 8 Hz was identified during both encoding and retrieval, only in the anterior hippocampus.
Our findings are consistent with the view that an anterior/posterior functional gradient is present in the hippocampus, and involves two distinct neuronal networks, supporting either encoding or retrieval processes. Although this is a single
case scenario, these findings suggest that neural
oscillations during spatial navigation do vary across hippocampal subregions, as a function of encoding versus retrieval processes during the mnemonic process. In this single
case study, the results point to the presence of a dual involvement of multiple frequency bands across hippocampal subregions during encoding and retrieval. Although these results need generalization, they provide a new perspective on distinct physiological properties of the anterior and posterior hippocampus in human spatial navigation during encoding and retrieval.