目的:在过去的几十年中,食物过敏(FA)的患病率在全球范围内有所增加。牛奶,鸡蛋,花生是最常见的过敏原之一,可引起过敏反应。因此,我们的目的是确定可以预测IgE介导的牛奶过敏的持久性和/或严重程度的生物标志物,鸡蛋,和花生通过系统审查。
方法:本系统评价按照国际前瞻性系统评价注册的方案进行。两名独立作者从PubMed中提取了感兴趣的研究,SciELO,EMBASE,Scopus,和Ebsco数据库,并使用纽卡斯尔-渥太华量表评估其质量。
结果:我们选择了14篇描述1,398例患者的文章。在八种确定的生物标志物中,总IgE,特异性IgE(sIgE),IgG4是最常被引用的对牛奶持续过敏的生物标志物,鸡蛋,还有花生.皮肤点刺试验,端点测试,和sIgE截止水平可以预测这些食物对挑战的积极反应。嗜碱性粒细胞活化测试是对牛奶和花生的过敏反应的严重程度和/或阈值的生物标志物。
结论:只有少数出版物确定了FA的持久性或严重程度以及口服食物挑战的可能预后指标。这表明需要更多的生物标志物来确定严重食物过敏反应的可能性。
The prevalence of food allergies (FA) has increased worldwide over the last few decades. Milk, eggs, and peanuts are among the most common allergens and can cause anaphylaxis. Therefore, we aimed to identify biomarkers that could predict the persistence and/or severity of IgE-mediated allergies to milk, eggs, and peanuts via a systematic
review.
This systematic
review proceeded according to a protocol registered in the International Prospective Register of Systematic Reviews. Two independent authors extracted studies of interest from PubMed, SciELO, EMBASE, Scopus, and Ebsco databases and assessed their quality using the Newcastle-Ottawa Scale.
We selected 14 articles describing 1,398 patients. Among eight identified biomarkers, total IgE, specific IgE (sIgE), and IgG4 were the most often cited biomarkers of persistent allergies to milk, eggs, and peanuts. Skin prick tests, endpoint tests, and sIgE cutoff levels may predict positive responses to challenges with these foods. The basophil activation test is a biomarker for the severity and/or threshold of allergic reactions to milk and peanuts.
Only a few publications identified possible prognostic indicators of the persistence or severity of FA and outcomes of oral food challenges, indicating that more accessible biomarkers are needed to determine the likelihood of having a severe food allergic reaction.