蛋白激酶TAOK3,属于MAP激酶家族,是三个密切相关的成员之一,即TAOK1、TAOK2和TAOK3。我们对不同癌症类型的TAOK3进行了泛癌症调查,包括子宫癌肉瘤,胃和胰腺腺癌,子宫内膜癌,更好地了解TAOK3在癌症中的作用。在至少16种癌症中,我们的发现表明TAOK3的表达水平在正常组织和肿瘤组织之间有很大差异.此外,我们的研究首次确定了TAOK3位点S331和S471在肾透明细胞癌中的致癌作用,多形性胶质母细胞瘤,肝细胞癌,肺腺癌,和胰腺腺癌,表明他们参与了癌症进展。此外,我们的数据分析表明,拷贝数变异是TAOK3基因中最普遍的突变形式,TAOK3mRNA与DNA启动子甲基化呈负相关。此外,我们的分析表明,TAOK3可能作为几种癌症的预后标志物,包括结肠腺癌,肾透明细胞癌,低级胶质瘤,肺腺癌,间皮瘤,和肝细胞癌。此外,我们对特征癌基因的研究发现,在我们检查的大多数恶性肿瘤中,TAOK3与SMAD2,SMAD4和RNF168之间存在正相关.TAOK3还与四种类型癌症中的突变频率和微卫星不稳定性相关。在许多恶性肿瘤中,许多免疫相关基因与TAOK3水平密切相关。TAOK3表达与免疫浸润呈正相关,其中包括活化的CD4T细胞,CD8T细胞,和2型T辅助细胞。我们对TAOK3的泛癌症分析提供了对其在各种癌症类型中的潜在作用的重要见解。
The protein kinase TAOK3, belongs to the MAP kinase family, is one of three closely related members, namely TAOK1, TAOK2, and TAOK3. We performed a pan-cancer investigation of TAOK3 across different cancer types, including uterine carcinosarcoma, adenocarcinoma of the stomach and pancreas, and endometrial carcinoma of the uterus, to better understand TAOK3\'s role in cancer. In at least 16 types of cancer, our findings indicate that TAOK3 expression levels differ considerably between normal and tumor tissues. In addition, our
study is the first to identify the oncogenic role of TAOK3 locus S331 and S471 in renal clear cell carcinoma, Glioblastoma Multiforme, hepatocellular carcinoma, Lung adenocarcinoma, and Pancreatic adenocarcinoma, indicating their involvement in cancer progression. In addition, our data analysis indicates that copy number variation is the most prevalent form of mutation in the TAOK3 gene, and that there is a negative correlation between TAOK3 mRNA and DNA promoter methylation. Moreover, our analysis suggests that TAOK3 may serve as a prognostic marker for several kinds of cancer, including Colon adenocarcinoma, renal clear cell carcinoma, Lower Grade Glioma, Lung adenocarcinoma, Mesothelioma, and hepatocellular carcinoma. In addition, our research on signature cancer genes has uncovered a positive association between TAOK3 and SMAD2, SMAD4, and RNF168 in most of the malignancies we have examined. TAOK3 is also correlated with the frequency of mutations and microsatellite instability in four types of cancer. Numerous immune-related genes are closely associated with TAOK3 levels in numerous malignancies. TAOK3 expression is positively correlated with immune infiltrates, which include activated CD4 T cells, CD8 T cells, and type 2T helper cells. Our pan-cancer analysis of TAOK3 provides vital insight into its potential role across a variety of cancer types.