■阿尔茨海默病(AD)和其他神经退行性疾病之间存在嗅觉障碍的差异。嗅觉缺陷可能是AD早期和鉴别诊断的潜在标志。我们旨在评估AD和其他神经退行性疾病患者的嗅觉功能,使用亚组分析进一步评估气味测试,探讨影响嗅觉表现的调节因素。
■在2022年7月27日之前发表的关于AD和其他神经退行性疾病嗅觉评估的横断面研究英文,在PubMed上搜索,Embase和Cochrane.经过文献筛选和质量评估,使用stata14.0软件进行荟萃分析。
■包括42篇文章,涉及12种气味测试,评估了2,569名AD患者。研究表明,嗅觉测试可以区分AD和轻度认知障碍(MCI),路易体病(LBD),抑郁症,和血管性痴呆(VaD),但不是来自额颞叶痴呆(FTD)等疾病。我们的发现表明,在区分AD和MCI时,宾夕法尼亚大学气味识别测试(UPSIT)是最常用的(95CI:-1.12至-0.89)。而简短气味识别测试(B-SIT),是AD中使用最广泛的方法LBD组。进一步的亚组分析表明,所使用的嗅觉测试方法导致了AD组嗅觉阈值和歧视评分的异质性。MCI.虽然调节变量包括年龄,MMSE分数,AD教育年限与LBD,是研究中异质性的原因。
■我们的发现表明,嗅觉测试在AD的早期鉴别诊断中具有潜在价值。UPSIT及其简化变体,B-SIT,是分析中广泛使用的方法。
■https://www.crd.约克。AC.uk/PROSPERO/display_record。php?RecordID=357970(PROSPERO,注册号CRD42022357970)。
UNASSIGNED: There are discrepancies of olfactory impairment between Alzheimer\'s disease (AD) and other neurodegenerative disorders. Olfactory deficits may be a potential marker for early and differential diagnosis of AD. We aimed to assess olfactory functions in patients with AD and other neurodegenerative disorders, to further evaluate the smell tests using subgroup analysis, and to explore moderating factors affecting olfactory performance.
UNASSIGNED: Cross-sectional studies relating to olfactory assessment for both AD and other neurodegenerative disorders published before 27 July 2022 in English, were searched on PubMed, Embase and Cochrane. After literature screening and quality assessment, meta-analyses were conducted using stata14.0 software.
UNASSIGNED: Forty-two articles involving 12 smell tests that evaluated 2,569 AD patients were included. It was revealed that smell tests could distinguish AD from mild cognitive impairment (MCI), Lewy body disease (LBD), depression, and vascular dementia (VaD), but not from diseases such as frontotemporal dementia (FTD). Our finding indicated that in discriminating AD from MCI, the University of Pennsylvania Smell Identification Test (UPSIT) was most frequently used (95%CI: -1.12 to -0.89), while the Brief Smell Identification Test (B-SIT), was the most widely used method in AD vs. LBD group. Further subgroup analyses indicated that the methods of smell test used contributed to the heterogeneity in olfactory threshold and discrimination scores in group AD vs. MCI. While the moderating variables including age, MMSE scores, education years in AD vs. LBD, were account for heterogeneity across studies.
UNASSIGNED: Our finding suggests smell tests have potential value in early differential diagnosis of AD. UPSIT and its simplified variant, B-SIT, are widely used methods in the analyses.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/display_record.php? RecordID = 357970 (PROSPERO, registration number CRD42022357970).