国际癌症研究机构(IARC)最近对草甘膦进行了分类,全世界使用最多的除草剂,可能是人类致癌物.在意大利进行的一项多中心病例对照研究中,我们调查了草甘膦职业暴露与淋巴瘤亚型风险之间的关系。
意大利基因-环境相互作用在淋巴瘤病因(ItGxE)研究于2011-17年在六个意大利中心进行。总的来说,867例淋巴瘤和774例对照参与了研究。根据详细的问卷信息,职业专家分类持续时间,信心,频率,和每个研究对象的草甘膦暴露强度。使用无条件回归分析,我们模拟了与草甘膦暴露相关的主要淋巴瘤亚型的风险,性别,教育,和学习中心。
非常少的研究对象(2.2%)被分类为曾经暴露于草甘膦。滤泡性淋巴瘤(FL)的风险在被分类为曾经暴露于草甘膦的受试者中提高了7倍,与中高累积暴露水平相关的4.5倍,12倍,中高曝光强度,每年暴露10天或更长时间的6倍。所有暴露指标都检测到显著的上升趋势,但持续时间。具有四个独立指标的上升趋势的总体p值为1.88×10-4。与淋巴瘤(任何亚型)的风险无关,非霍奇金淋巴瘤,B细胞淋巴瘤,或FL以外的主要淋巴瘤亚型。
我们的研究结果为IARC将草甘膦分类为2A组人类致癌物的决定提供了有限的支持。
The International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into the association between occupational exposure to glyphosate and risk of lymphoma subtypes in a multicenter
case-control study conducted in Italy.
The Italian Gene-Environment Interactions in Lymphoma Etiology (ItGxE) study took place in 2011-17 in six Italian centres. Overall, 867 incident lymphoma cases and 774 controls participated in the study. Based on detailed questionnaire information, occupational experts classified duration, confidence, frequency, and intensity of exposure to glyphosate for each study subject. Using unconditional regression analysis, we modelled risk of major lymphoma subtypes associated with exposure to glyphosate adjusted by age, gender, education, and study centre.
Very few study subjects (2.2%) were classified as ever exposed to glyphosate. Risk of follicular lymphoma (FL) was elevated 7-fold in subjects classified as ever exposed to glyphosate with medium-high confidence, 4.5-fold in association with medium-high cumulative exposure level, 12-fold with medium-high exposure intensity, and 6-fold with exposure for 10 days or more per year. Significant upward trends were detected with all the exposure metrics, but duration. The overall p-value for an upward trend with four independent metrics was 1.88 × 10- 4. There was no association with risk of lymphoma (any subtype), Non Hodgkin Lymphoma, B-cell lymphoma, or the major lymphoma subtypes other than FL.
Our findings provide limited support to the IARC decision to classify glyphosate as Group 2A human carcinogen.