本文的目的是系统分析硅酸钙基密封剂与树脂基密封剂对恒牙非手术牙髓治疗的临床和影像学结果的影响。方法:根据Cochrane干预措施系统评价手册和系统评价和荟萃分析首选报告项目(PRISMA)的指南进行研究。使用PubMed/MEDLINE进行文献检索,Cochrane中央控制试验登记册,WebofScience,DOAJ和OpenGrey没有语言限制。两名审稿人批判性地评估了这些研究的资格。建议的分级,评估,进行开发和评估(等级)以评估证据。采用RevMan软件对亚组数据进行Meta分析(p<0.05)。结果:纳入研究的结果表明,两组在闭塞后24h疼痛水平上没有显着差异(平均差异(MD),−0.19,95%CI=−0.43−0.06,p=0.14,I2=0%),但在48小时(MD,−0.35,95%CI=−0.64−0.05,p=0.02,I2=0%),观察到有利于硅酸钙密封剂的显着差异。此外,由于术后疼痛的发作风险或强度,两种密封剂之间没有显着差异,需要镇痛和挤压的密封剂。纳入研究之间使用Q检验评估的异质性为97%(I2)。结论:在本综述的局限性内,本文表明,硅酸钙基密封剂表现出最佳性能,在封堵后疼痛的平均水平方面与树脂基密封剂相似,发病风险和疼痛强度在24和48小时。从纳入的研究的观察结果是在硅酸钙基密封剂的临床评估提供了信息,并提供了证据的传导精心设计,未来至少四年的随机对照临床试验。
The aim of this paper is to systematically analyse the effect of calcium silicate-based sealers in comparison to resin-based sealers on clinical and radiographic outcomes of non-surgical endodontic treatment in permanent teeth. Methods: The study was conducted according to the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions and Preferred Reporting Items for Systematic
Review and Meta-Analyses (PRISMA) statement. The literature search was performed using PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, DOAJ and OpenGrey with no language restrictions. Two reviewers critically assessed the studies for eligibility. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) was carried out to assess the evidence. Meta-analysis of the pooled data with subgroups was carried out using the RevMan software (p < 0.05). Results: Results from the included studies showed that there were no significant differences between the groups in the 24 h post-
obturation pain levels (mean difference (MD), −0.19, 95% CI = −0.43−0.06, p = 0.14, I2 = 0%), but at 48 h (MD, −0.35, 95% CI = −0.64−0.05, p = 0.02, I2 = 0%), a significant difference was observed in favour of calcium silicate sealers. Furthermore, there were no significant differences between the two sealers due to risk of onset or intensity of postoperative pain, need for analgesic and extrusion of the sealer. The heterogeneity assessed using Q test between the included studies was 97% (I2). Conclusions: Within the limitations of this
review, the paper shows that calcium silicate-based sealers exhibited optimal performance with similar results to resin-based sealers in terms of average level of post-
obturation pain, risk of onset and pain intensity at 24 and 48 h. The observations from the included studies are informative in the clinical evaluation of calcium silicate-based sealers and provide evidence for the conduction of well-designed, controlled randomised clinical trials for a period of at least four years in the future.