■为了评估患病率,由全身性疾病引起并接受rh-NGF治疗的中度和重度神经营养性角膜病变(NK)的临床眼部表现和角膜愈合。
■生物医学和牙科科学与形态功能成像系,眼科诊所,梅西纳大学,意大利。
■病例系列回顾性观察性研究。
■在这项回顾性观察研究中,纳入了11名患者(5名女性和6名男性),年龄在24至88岁(55.4±21.3岁)之间,患有由全身性疾病引起的中度和重度NK。发放了VAS问卷。眼部检查包括裂隙灯评估,用角膜描记器5M进行眼表评估(Oculus,德国),使用Cochet-Bonnet美度计的角膜敏感性(Lunneaux,法国)和使用AC-OCT(DRI,Triton,Topcon,日本)。确定了NK的潜在系统性原因。
■NK的主要原因是神经瘤手术后(36%),其次是糖尿病(18%)。其余原因为类风湿性关节炎(9%),创伤后(9%),术后(9%),乌托邦(9%),严重疾病(9%)。7只眼表现出严重的NK级别并伴有角膜溃疡,其中4只眼表现为中度。rh-NGF(Cenegermin)以标准方案每天一滴给药6次,持续8周。在治疗结束时记录所有角膜缺损的完全愈合。
■神经瘤术后是NK的最常见原因,严重级别在临床上表现得更多。rh-NGF被证明可有效促进角膜恢复,治疗后所有缺损均已愈合。
UNASSIGNED: To evaluate the prevalence, clinical ocular presentation and corneal healing in moderate and severe neurotrophic keratopathy (NK) caused by systemic diseases and treated with rh-NGF.
UNASSIGNED: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Ophthalmology Clinic, University of Messina, Italy.
UNASSIGNED: Retrospective observational study of
case series.
UNASSIGNED: In this retrospective observational study 11 patients (five female and six males) aged from 24 to 88 years (55.4 ± 21.3 years) with moderate and severe NK caused by systemic diseases were enrolled. The VAS questionnaire was dispensed. The ocular examination comprised slit lamp evaluation, ocular surface assessment with Keratograph 5M (Oculus, Germany), corneal sensitivity with Cochet-Bonnet esthesiometer (Lunneaux, France) and corneal thickness measurement with AC-OCT (DRI, Triton, Topcon, Japan). The underlying systemic causes of NK were determined.
UNASSIGNED: The main cause of NK was post-neuroma surgery (36%), followed by diabetes (18%). The remaining causes were rheumatoid arthritis (9%), post-traumatic (9%), post-surgery (9%), atopia (9%), Graves\' disease (9%). Seven eyes presented severe grade of NK with corneal ulcer and in four a moderate grade was registered. The rh-NGF (Cenegermin) was administered with a standard protocol one drop six times daily for 8 weeks. The complete healing of all corneal defects was registered at the end of the treatment.
UNASSIGNED: The post-neuroma surgery was the most common cause of NK and severe grade was clinically more represented. The rh-NGF proved effective to promote corneal recovery with all defects healed after the treatment.