■磁共振波谱(MRS)是一种成像技术,用于测量组织中的代谢变化。由于缺乏证据,MRS不是诊断神经退行性疾病的优先事项,因为它是一种相对专业的技术,需要专门的设备和专业知识来执行和解释。本系统综述旨在全面收集最常见的神经退行性疾病的MRS结果。
■对四个电子数据库的系统搜索(PubMed,Scopus,WebofScience,和ScienceDirect)是针对2017年至2022年发表的研究进行的。选择了提供特定生物标志物水平的文章,以及通过治疗评估疾病的研究,应用除1H以外的原子核的特色MRS,或比较不同的动物模型均被排除。
■共25篇,在引言中加上3篇文章以获取额外信息,包括在这次审查中。六种最常见的神经退行性疾病,即,老年痴呆症和帕金森氏症,亨廷顿舞蹈病,共济失调,多发性硬化症(MS),多系统萎缩(MSA),通过MRS检查进行性核上性麻痹(PSP)。在所有这些疾病中都可以看到N-乙酰天冬氨酸(NAA)的变化和比例,这可能导致早期诊断。然而,还有其他生物标志物,如Cr和Chon,这可以给出令人信服的结果。
■这项观察性研究是使用MRS作为诊断方法证明神经退行性疾病期间代谢变化的最新证据的首次综合。研究结果表明,阿尔茨海默病(AD)中的N-乙酰天冬氨酸(NAA)和NAA/Cr比率降低,帕金森病(PD),共济失调,MS,反映神经元丢失或功能障碍。在一些研究中发现胆碱和肌醇增加,提示细胞膜更新和神经炎症。其他代谢物如谷氨酸和γ-氨基丁酸的研究结果不太一致。然而,由于缺乏对相同兴趣量(VOI)的研究以及参与者数量少,因此存在局限性.
UNASSIGNED: Magnetic resonance spectroscopy (MRS) is an imaging technique used to measure metabolic changes in the tissue. Due to the lack of evidence, MRS is not a priority in diagnosing
neurodegenerative diseases because it is a relatively specialized technique that requires specialized equipment and expertise to perform and interpret. This systematic
review aimed to present a comprehensive collection of MRS results in the most common
neurodegenerative diseases.
UNASSIGNED: A systematic search of four electronic databases (PubMed, Scopus, Web of Science, and ScienceDirect) was conducted for studies published from 2017 to 2022. Articles that provided specific biomarker levels were selected, and studies that assessed the diseases via treatment, featured MRS applying nuclei other than 1H, or compared different animal models were excluded.
UNASSIGNED: A total of 25 articles, plus 3 articles for extra information in the introduction, were included in this
review. Six of the most common
neurodegenerative diseases, i.e., Alzheimer\'s and Parkinson\'s disease, Huntington chorea, ataxia, multiple sclerosis (MS), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) were examined via MRS. The changes and ratios of N-acetylaspartate (NAA) could be seen in all of these disorders, which could lead to early diagnosis. However, there are other biomarkers, such as Cr and Chon, which can give convincing results.
UNASSIGNED: This observational study is the first synthesis of the latest evidence proving metabolic changes during neurodegenerative diseases using MRS as a diagnosis method. The findings indicate decreased N-acetylaspartate (NAA) and NAA/Cr ratios in Alzheimer\'s disease (AD), Parkinson\'s disease (PD), ataxias, and MS, reflecting neuronal loss or dysfunction. Increased choline and myo-inositol were noted in some studies, suggesting cell membrane turnover and neuroinflammation. Findings were less consistent for other metabolites like glutamate and gamma-aminobutyric acid. However, there were limitations due to the lack of studies on the same volumes of interest (VOIs) and the small number of participants.