PDF(Pubmed)
Abstract：
Neurogenesis is a high energy-demanding process, which is why blood vessels are an active part of the neurogenic niche since they allow the much-needed oxygenation of progenitor cells. In this regard, although neglected for a long time, the \"oxygen niche\" should be considered an important intervenient in adult neurogenesis. One possible hypothesis for the failure of numerous neuroprotective trials is that they relied on compounds that target a highly specific neuroprotective pathway. This approach may be too limited, given the complexity of the processes that lead to cell death. Therefore, research should adopt a more multifactorial approach. Among the limited range of agents with multimodal neuromodulatory capabilities, hyperbaric oxygen therapy has demonstrated effectiveness in reducing secondary brain damage in various brain injury models. This therapy functions not only as a neuroprotective mechanism but also as a powerful neuroregenerative mechanism.
摘要：
神经发生是一个对能量要求很高的过程,这就是为什么血管是神经源性生态位的活跃部分，因为它们允许祖细胞急需的氧合。在这方面,虽然被忽视了很长时间，“氧位”应被认为是成人神经发生的重要干预因素。许多神经保护试验失败的一个可能假设是它们依赖于靶向高度特异性神经保护途径的化合物。这种方法可能太有限，考虑到导致细胞死亡的过程的复杂性。因此,研究应该采用更多的多因素方法。在有限范围的具有多模式神经调节能力的药物中，在各种脑损伤模型中，高压氧疗法已证明可有效减少继发性脑损伤。这种疗法不仅作为神经保护机制，而且作为强大的神经再生机制。
