UNASSIGNED:本研究旨在评估冷冻配子(双冷冻移植(DFT))胚胎冷冻移植的新生儿和儿童生长结果。
UNASSIGNED:这项巢式病例对照研究包括6,705名在生殖医学中心进行胚胎移植后单胎活产的妇女,山东大学,从2008年到2020年。其中,745名妇女使用从冷冻配子(DFT)发育的胚胎进行冷冻胚胎移植(FET)。在评估结局之前,使用倾向评分方法根据产妇年龄和体重指数(BMI)平衡两组。在使用倾向评分方法以1:4的比例匹配年龄和BMI后,对照组招募了2,980名接受新鲜胚胎移植(ET)的女性和2,980名接受新鲜配子FET的女性。出生的孩子被跟踪到至少5岁,有些人被跟踪了10年。比较三组的新生儿结局和儿童生长情况。
UNASSIGNED:DFT组(3,462g)的平均出生体重明显高于FET组(3,458g)和ET组(3,412g)。DFT和FET组中的大胎龄(LGA)婴儿的比率高于ET组(30.9%vs.24.8%;29.4%与24.8%,分别)。在调整了三个模型中不同的混杂组合后,DFT和FET组的出生体重和LGA风险仍高于ET组,模型中趋势的P值组显著。在儿童发育的多元线性回归分析中,DFT和FET组出生的儿童的身高Z评分高于ET组的儿童(β=0.21,95%CI0.07-0.35;b=0.17,95%CI0.05-0.28)。然而,包括体重Z评分和BMIZ评分在内的儿童生长测量在三组间无显著差异.此外,DET出生的男性儿童比例高于ET。
未经授权:与DFT妊娠相关的LGA婴儿风险增加。在这一组中,孩子们在未来比FET后更高。相关的病因和病理生理机制仍有待揭示。在未来,精心设计,深入收集患者特征的观察性研究可能会更清楚地揭示这一问题。
UNASSIGNED: This study aims to evaluate neonatal and children growth outcomes of cryotransfer of embryos developed from frozen gametes [double frozen transfer (DFT)].
UNASSIGNED: This nested
case-control study included 6,705 women who had a singleton live birth after embryo transfer at the Center for Reproductive Medicine, Shandong University, from 2008 to 2020. Of these, 745 women underwent frozen embryo transfer (FET) using embryos developed from frozen gametes (DFT). Propensity score methodology was used to balance the two groups by maternal age and body mass index (BMI) before evaluating outcomes. After age and BMI were matched using the propensity score methodology in a ratio of 1:4, the control groups enrolled 2,980 women who underwent fresh embryo transfer (ET) and 2,980 women underwent FET from fresh gametes. The children born were followed to at least 5 years of age, and some were followed up to 10 years. Neonatal outcomes and childhood growth measurements were compared among the three groups.
UNASSIGNED: The average birth weight of the DFT group (3,462 g) was significantly higher than the FET group (3,458 g) and ET group (3,412 g). The rate of large for gestational age (LGA) babies in the DFT and FET group was higher than that for the ET group (30.9% vs. 24.8%; 29.4% vs. 24.8%, respectively). After adjusting for different confounder combinations in the three models, the birth weight and risk of LGA in the DFT and FET groups were still higher than in the ET group, and the values group of P for trend in the models were significant. In multiple linear regression analysis of the children\'s development, the height Z-score of children born from the DFT and FET group was higher than that for children from the ET group (β = 0.21, 95% CI 0.07-0.35; b = 0.17, 95% CI 0.05-0.28, respectively). However, childhood growth measurements including body weight Z-score and BMI Z-score were not significantly different among the three groups. In addition, the proportion of male children born from DET was higher than that from ET.
UNASSIGNED: There is an increased risk of LGA babies associated with pregnancies conceived from DFT. Children are inclined to be taller in the future in this group than after FET. The related etiology and pathophysiology mechanisms still need to be revealed. In the future, well-designed, observational studies with in-depth collection of patients\' characteristics may shed more light on this issue.