neonatal outcome

新生儿结局
  • 文章类型: Journal Article
    背景:适当的妊娠期体重增加(GWG)对于母体和胎儿的健康至关重要。对于白人女性的双胎妊娠,医学研究所(IOM)指南可用于监测和指导GWG。我们旨在从外部验证和比较IOM指南和最近发布的中国双胎妊娠妇女指南关于其建议对总GWG(TGWG)的适用性。
    方法:2016年10月至2020年6月期间,在广州对年龄在18-45岁并在≥26孕周分娩双胞胎的1534名妇女进行了回顾性队列研究。中国。妇女的TGWG被归类为不足,最优,以及根据国际移民组织和中国指南的超额。使用多变量广义估计方程逻辑回归来估计TGWG类别与不良新生儿结局之间的风险关联。计算Cohen的Kappa系数以评估IOM与中国指南之间的一致性。
    结果:由国际移民组织或中国指南定义,TGWG不足的女性,与具有最佳TGWG的那些相比,显示小于胎龄出生和新生儿黄疸的风险较高,而TGWG过多的女性分娩胎龄较大的婴儿的风险较高.两个指南之间的一致性相对较高(Kappa系数=0.721)。与两组指南中的最佳TGWG组相比,根据中国指南被划分为最佳组,但根据IOM指南被划分为不适当组的女性(n=214)显示,所有不良新生儿结局合并风险均无统计学显著增加.
    结论:IOM和中国指南均适用于中国双胎妊娠妇女。
    Appropriate gestational weight gain (GWG) is essential for maternal and fetal health. For twin pregnancies among Caucasian women, the Institute of Medicine (IOM) guidelines can be used to monitor and guide GWG. We aimed to externally validate and compare the IOM guidelines and the recently released guidelines for Chinese women with twin pregnancies regarding the applicability of their recommendations on total GWG (TGWG).
    A retrospective cohort study of 1534 women who were aged 18-45 years and gave birth to twins at ≥ 26 gestational weeks between October 2016 and June 2020 was conducted in Guangzhou, China. Women\'s TGWG was categorized into inadequate, optimal, and excess per the IOM and the Chinese guidelines. Multivariable generalized estimating equations logistic regression was used to estimate the risk associations between TGWG categories and adverse neonatal outcomes. Cohen\'s Kappa coefficient was calculated to evaluate the agreement between the IOM and the Chinese guidelines.
    Defined by either the IOM or the Chinese guidelines, women with inadequate TGWG, compared with those with optimal TGWG, demonstrated higher risks of small-for-gestational-age birth and neonatal jaundice, while women with excess TGWG had a higher risk of delivering large-for-gestational-age infants. The agreement between the two guidelines was relatively high (Kappa coefficient = 0.721). Compared with those in the optimal TGWG group by both sets of the guidelines, women classified into the optimal group by the Chinese guidelines but into the inadequate group by the IOM guidelines (n = 214) demonstrated a statistically non-significant increase in the risk of all the adverse neonatal outcomes combined.
    The IOM and the Chinese guidelines are both applicable to Chinese women with twin pregnancies.
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  • 文章类型: Journal Article
    BACKGROUND: Pregnancies that are prenatally identified to have fetal anomalies are complex and require expert multidisciplinary care. As many conditions can impact the fetus prenatally and require intervention, an enhanced recovery after surgery (ERAS) for lower urinary tract obstruction (LUTO) is being evaluated to determine the level of evidenced-based data available.
    OBJECTIVE: The percutaneous ultrasound-guided fetal surgery procedure for bladder neck obstruction is the focus for elements of preoperative counseling, intraoperative procedure/risk complications, and postoperative management.
    METHODS: A quality improvement review Squire 2.0 (2000-2020) was undertaken for the percutaneous LUTO fetal surgery shunting (lower urinary tract obstruction), process and procedure which require 2 process pathways, one to evaluate the fetal candidate and a second to treat. This structured review is focused on identifying the process elements to allow the determination of the number of evidenced-based elements that would allow for audit and measurement of the clinical element variance for comparative feedback to the individual surgical provider or surgery center.
    METHODS: Titles and abstracts were screened to identify potentially relevant articles with priority given to meta-analyses, systematic reviews, randomized controlled studies, nonrandomized controlled studies, reviews, and case series.
    RESULTS: A series of potential clinical elements for the diagnostic fetal evaluation and for the 3 protocol areas of surgical care for the procedures (pre-, intra-, and postoperative care) are identified using an ERAS-like process.
    CONCLUSIONS: The identified clinical elements have the potential for ERAS-LUTO fetal therapy guideline. Multidisciplinary collaboration (surgeon, anesthesia, nursing, imaging, and laboratory) is required for ERAS quality improvement in the pre-, intra-, and postoperative processes. Process elements in each of the operative areas can be audited, evaluated, compared, and modified/improved.
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  • 文章类型: Journal Article
    目的:比较根据2015年发表的国际妇产科超声学会(ISUOG)定义诊断的选择性胎儿生长受限(sFGR)的单绒毛膜妊娠队列的结局,以及根据2019年发表的新专家共识诊断参数被视为sFGR的队列。方法:这是一项回顾性研究,在2010年1月1日至2019年7月30日期间进行。我们回顾了我们中心所有单绒毛膜妊娠的医疗记录,包括围产期结局。怀孕并发胎儿异常,感染,双胎输血综合征,双胎贫血-红细胞增多症序列和双胎反向动脉灌注序列被排除.根据2015年ISUOG定义将患者分组为:正常(第1组),sFGR(第2组),和生长异常的单绒毛膜妊娠不符合sFGR的全部标准(第3组)。在进行了初步分类之后,一个额外的群体,被创造,包括根据2019年专家共识参数(第4组)重新分类为sFGR的所有妊娠。结果:在研究期间,我们中心跟踪291例单绒毛膜妊娠,其中132人符合纳入最终分析的资格。在将基于专家共识的参数应用于研究人群后,sFGR的患病率从17.4%增加到26.5%。与第1组相比,第2组的急诊剖宫产率更高,新生儿重症监护入院,有创和无创通气,表面活性剂的使用,代谢紊乱和出生时胎龄较低。相比之下,第1组和第4组的新生儿结局无显著差异.结论:当2019年基于共识的sFGR诊断参数应用于我们的研究人群时,sFGR病例数量增加了50%以上,围产期结局没有任何改善。需要更大的前瞻性研究来检查这些新参数对单绒毛膜妊娠sFGR的潜在临床意义。
    Objective: To compare the outcomes of a cohort of monochorionic pregnancies with selective fetal growth restriction (sFGR) diagnosed according to the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) definition published in 2015 with a cohort considered as sFGR according to new expert consensus-based diagnostic parameters published in 2019.Methods: This was a retrospective study, conducted between January 1st 2010 and July 30th 2019. We reviewed the medical records of all the monochorionic pregnancies followed in our center including perinatal outcomes. Pregnancies complicated by fetal anomalies, infection, twin-twin transfusion syndrome, twin anaemia-polycythemia sequence and twin reversed arterial perfusion sequence were excluded. Patients were grouped according to the 2015 ISUOG definition into: normal (Group 1), sFGR (Group 2), and monochorionic pregnancies with abnormal growth that did not fulfill the full criteria for sFGR (Group 3). After the initial classifications were made, an additional group, was created, including all pregnancies reclassified as sFGR according to the 2019 expert consensus parameters (Group 4).Results: During the study period, 291 monochorionic pregnancies were followed in our center, 132 of whom were eligible for inclusion in the final analysis. The prevalence of sFGR increased from 17.4% to 26.5% after applying the expert consensus-based parameters to the study population. Compared to group 1, group 2 had higher rates of emergency cesarean, neonatal intensive care admissions, invasive and noninvasive ventilation, surfactant use, metabolic disorders and lower gestational ages at birth. In contrast, the neonatal outcomes of Groups 1 and 4 were not significantly different.Conclusion: When the 2019 consensus-based diagnostic parameters for sFGR were applied to our study population, the number of sFGR cases increased by over 50%, without any improvements in perinatal outcomes. Larger prospective studies are needed to examine the potential clinical implications of these new parameters for sFGR in monochorionic pregnancies.
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  • 文章类型: Comparative Study
    To provide guidelines regarding the benefits and risks for the neonate and the child of planning vaginal delivery versus planning elective cesarean section in case of term breech presentation.
    MedLine and Cochrane Library databases search and review of the main foreign guidelines.
    In case of term breech presentation, planned vaginal delivery might be associated with an increased composite risk of perinatal mortality or occurrence of a combined outcome of serious neonatal morbidity in comparison to elective cesarean section (LE2). In case of planned vaginal delivery of term breech presentation, the risk of perinatal mortality is around 1‰ (LE3). It is potentially less but still exists in case of elective cesarean section (LE2). Risks of neonatal trauma - especially fracture of clavicle and breech hematoma -, Apgar score lower than 7 at 5minutes, and need for neonatal intubation and ventilation, are increased in case of planned vaginal delivery (LE2) and are around 1% (LE3). However, no difference has been demonstrated between planned vaginal and planned cesarean delivery regarding neurodevelopmental outcomes at 2 years (LE2), cognitive and psychomotor outcomes between 5 and 8 years (LE3), and adult intellectual performances (LE4).
    In case of term breech presentation, risks of severe complications for neonate and child are low in case of planned vaginal delivery or elective cesarean section. Short-term benefit/risk balance for the neonate might favor elective cesarean section but long-term morbidity seems to be similar whatever the delivery route (Professional consensus).
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  • 文章类型: Journal Article
    Intrapartum fetal scalp blood sampling (FBS) (pH or lactate) has not been shown to reduce emergency cesarean sections or operative vaginal births or improve long-term perinatal outcomes. In contrast, it is associated with rare but potentially very serious complications such as leakage of cerebro-spinal fluid (CSF) and perinatal hemorrhagic shock. Therefore, it does not fulfill the \"First Do No Harm\" principle and its use during labor should be critically re-evaluated.
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