世界卫生组织承认各国有必要将被忽视的热带病护理纳入其日常医疗保健系统。然而,在流行国家已经观察到真菌瘤的低检出率和在医疗机构的晚期出现,包括乌干达。
■授权乌干达北部的社区卫生工作者(CHW)识别并将其转介给医疗机构。
■这将是一项基于Gulu和Pader地区的阶梯式楔形集群随机试验,为期9个月,在不同的时间点从干预阶段到控制阶段进行顺序交叉,直到两个地区都暴露于干预。
该研究将利用乌干达北部医疗团与乌干达卫生部之间正在进行的伙伴关系,该伙伴关系已在古卢和帕德培训了300多名CHWs。研究评估将使用RE-AIM(达到,有效性,收养,实施,和维护)框架。该研究的预期结果是增加了对霉菌瘤嫌疑人的检测和转诊。将使用STATA17.0和Friedman统计或方差分析对数据进行分析,以确定病例识别和转介的增加。
■该研究获得了Mulago医院研究与伦理委员会(MHREC2406)的批准,并在泛非临床试验注册中心(PACTR202301534749787)注册。
■该试验的结果将发表在同行评审的期刊上。此外,调查结果将在会议上分享,与资助者,在其他研究会议上。
UNASSIGNED: The World Health Organization acknowledges the need for countries to incorporate neglected tropical disease care into their routine health care system. However, low detection rates and late presentation of mycetoma to health facilities have been observed in endemic countries, including Uganda.
UNASSIGNED: To empower community health workers (CHWs) in Northern Uganda to recognize and refer suspects of mycetoma to health facilities.
UNASSIGNED: This will be a stepped-wedge cluster-randomized trial based in Gulu and Pader districts over a period of 9 months with sequential crossover from intervention phase to the control phase at different time points until both districts are exposed to the intervention.
UNASSIGNED: The study will leverage on the ongoing partnership between Northern Uganda Medical Mission and the Uganda Ministry of Health that has trained over 300 CHWs in Gulu and Pader. The study evaluation will be done using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework. The expected outcome of the study is increased detection and referral of suspects of mycetoma. Data will be analyzed using STATA 17.0 and Friedman statistics or Analysis of Variance to determine increase in
case identifications and referrals.
UNASSIGNED: The study was approved by Mulago Hospital Research and Ethics Committee (MHREC 2406) and registered with Pan African Clinical Trial Registry (PACTR202301534749787).
UNASSIGNED: The results from this trial will be published in a peer-reviewed journal. In addition, the findings will be shared at conferences, with funders, and at other research meetings.