目的：描述1例梅毒性坏死性视网膜炎和1例假定梅毒性坏死性视网膜炎并存在下细胞分泌不足。
方法：我们报告2例坏死性视网膜炎，据指出，在视网膜炎的下边缘有黄色船形病变，类似于泪液下出血。在1例病例中，在光学相干断层扫描上确认了玻璃下位置。两种病例的性病研究实验室检查（VDRL）和梅毒螺旋体血凝（TPHA）均为阳性。但在一个案例中,房水的聚合酶链反应（PCR）对铜绿假单胞菌呈阳性，对哌拉西林反应良好。由于哌拉西林对假单胞菌有效，并且尚未研究哌拉西林在梅毒治疗中的功效，我们可能不得不将其视为假定的梅毒性视网膜炎。
结论：在文献中报道了2例梅毒性坏死性视网膜炎，这是一种罕见的表现。局限于内部视网膜的严重感染和坏死导致白细胞和坏死物质在下透明空间中的收集，并将沉降下来，导致下透明细胞分泌不足。文献中报道的2例和我们文章中报道的2例是梅毒性视网膜炎，其他实体中未报道。
结论：有可能的是，下泪液样细胞分泌不足可作为梅毒性坏死性视网膜炎的诊断线索。
OBJECTIVE: To describes one case of syphilitic necrotizing retinitis and one case of presumed syphilitic necrotizing retinitis with presence of subhyaloid hypopyon.
METHODS: We report two cases of necrotizing retinitis, which were noted to have yellow boat-shaped lesions at the inferior edge of retinitis resembling subhyaloid hypopyon. The subhyaloid location was confirmed on optical coherence tomography in one case. Both the cases were positive for venereal disease research laboratory test (VDRL) and Treponema pallidum hemagglutination (TPHA). But in one case, polymerase chain reaction (PCR) of the aqueous humor was positive for Pseudomonas aeruginosa and responded well to piperacillin. As piperacillin is effective against Pseudomonas and the efficacy of piperacillin in the management of syphilis is not studied, we may have to consider it as a case of presumed syphilitic retinitis.
CONCLUSIONS: Subhyaloid hypopyon is an uncommon presentation and is reported in two cases of syphilitic necrotizing retinitis in literature. Severe infection and necrosis confined to the inner retina leads to collection of white blood cells and necrotic material in the subhyaloid space and would settle down resulting in subhyaloid hypopyon. Two cases of subhyaloid hypopyon reported in literature and 2 cases reported in our article are syphilitic retinitis and is not reported in other entities.
CONCLUSIONS: It is possible that subhyaloid hypopyon may serve as a diagnostic cue in syphilitic necrotizing retinitis.
