Disorders in the inflammatory process underlie the pathogenesis of numerous diseases. The utilization of natural products as anti-inflammatory agents is a well-established approach in both traditional medicine and scientific research, with studies consistently demonstrating their efficacy in managing inflammatory conditions. Pequi oil, derived from Caryocar brasiliense, is a rich source of bioactive compounds including fatty acids and carotenoids, which exhibit immunomodulatory potential. This systematic review aims to comprehensively summarize the scientific evidence regarding the anti-inflammatory activity of pequi oil. Extensive literature searches were conducted across prominent databases (Scopus, BVS, CINAHL, Cochrane, LILACS, Embase, MEDLINE, ProQuest, PubMed, FSTA, ScienceDirect, and Web of Science). Studies evaluating the immunomodulatory activity of crude pequi oil using in vitro, in vivo models, or clinical trials were included. Out of the 438 articles identified, 10 met the stringent inclusion criteria. These studies collectively elucidate the potential of pequi oil to modulate gene expression, regulate circulating levels of pro- and anti-inflammatory mediators, and mitigate oxidative stress, immune cell migration, and cardinal signs of inflammation. Moreover, negligible to no toxicity of pequi oil was observed across the diverse evaluated models. Notably, variations in the chemical profile of the oil were noted, depending on the extraction methodology and geographical origin. This systematic review strongly supports the utility of pequi oil in controlling the inflammatory process. However, further comparative studies involving oils obtained via different methods and sourced from various regions are warranted to reinforce our understanding of its effectiveness and safety.

Nanoemulsion-based technology is developing rapidly in the food industry, especially in the design of delivery systems for bioactive compounds. This review presents an in-depth understanding of the composition, function, antibacterial mechanism and successful application of nanoemulsions as preservative agents against fish spoilage. The results showed that the inclusion of bioactive substances in the food-grade nanoemulsions encapsulation system could improve its stability, control its release, inhibit the microbial growth and reproduction through a variety of targets. These nanoemulsions can inhibit fish spoilage via reducing microbial load and retarding the oxidation of proteins and lipids, thereby maintaining quality attributes of fish. In addition, nanoemulsions could be coupled with vacuum package for enhancing microbial destruction, retaining nutritional value and extending the shelf-life of fish. Accordingly, nanoemulsions are suggested as a promising strategy to inhibit fish spoilage.

Over the last few decades, cancer has been considered a clinical challenge, being among the leading causes of mortality all over the world. Although many treatment approaches have been developed for cancer, chemotherapy is still the most utilized in the clinical setting. However, the available chemotherapeutics-based treatments have several caveats including their lack of specificity, adverse effects as well as cancer relapse and metastasis which mainly explains the low survival rate of patients. Lipid nanoparticles (LNPs) have been utilized as promising nanocarrier systems for chemotherapeutics to overcome the challenges of the currently applied therapeutic strategies for cancer treatment. Loading chemotherapeutic agent(s) into LNPs improves drug delivery at different aspects including specific targeting of tumours, and enhancing the bioavailability of drugs at the tumour site through selective release of their payload, thus reducing their undesired side effects on healthy cells. This review article delineates an overview of the clinical challenges in many cancer treatments as well as depicts the role of LNPs in achieving optimal therapeutic outcomes. Moreover, the review contains a comprehensive description of the many LNPs categories used as nanocarriers in cancer treatment to date, as well as the potential of LNPs for future applications in other areas of medicine and research.

The fabrication and application of nanoemulsions for incorporating and delivering diverse bioactive compounds, particularly hydrophobic substances, is becoming an increasing focus of research with the potential to improve the nutritional and health status of individuals. Constant advancements in nanotechnological approaches aid in the creation of nanoemulsions using diverse biopolymers such as proteins, peptides, polysaccharides, and lipids to improve the stability, bioactivity, and bioavailability of active hydrophilic and lipophilic compounds. This article provides a comprehensive overview of various techniques used to create and characterize nanoemulsions as well as theories for understanding their stability. The article also highlights the advancement of nanoemulsions in boosting the bioaccessibility of nutraceuticals to help advance their potential use in various food and pharmaceutical formulations.

Submicron droplets are ubiquitous in nature and widely applied in fields such as biomedical diagnosis and therapy, oil recovery and energy conversion, among others. The submicron droplets are kinetically stable, their submicron size endows them with good mobility in highly constricted pathways, and the high surface-to-volume ratio allows effective loading of chemical components at the interface and good heat transfer performance. Conventional generation technology of submicron droplets in bulk involves high energy input, or relies on chemical energy released from the system. Microfluidic methods are widely used to generate highly monodispersed micron-sized or bigger droplets, while downsizing to the order of 100 nm was thought to be challenging because of sophisticated nanofabrication. In this review, we summarize the microfluidic methods that are promising for the generation of submicron droplets, with an emphasize on the device fabrication, operational condition, and resultant droplet size. Microfluidics offer a relatively energy-efficient and versatile tool for the generation of highly monodisperse submicron droplets.

Microfluidics technology has emerged as a promising methodology for the fabrication of a wide variety of advanced drug delivery systems. Owing to its ability for accurate handling and processing of small quantities of fluidics as well as immense control over physicochemical properties of fabricated micro and nanoparticles (NPs), microfluidic technology has significantly improved the pharmacokinetics and pharmacodynamics of drugs. This emerging technology has offered numerous advantages over the conventional drug delivery methods for fabricating of a variety of micro and nanocarriers for poorly soluble drugs. In addition, a microfluidic system can be designed for targeted drug delivery aiming to increase the local bioavailability of drugs. This review spots the light on the recent advances made in the area of microfluidics including various methods of fabrication of drug carriers, their characterization, and unique features. Furthermore, applications of microfluidic technology for the robust fabrication and development of drug delivery systems, the existing challenges associated with conventional fabrication methodologies as well as the proposed solutions offered by microfluidic technology have been discussed in details.HighlightsMicrofluidic technology has revolutionized fabrication of tunable micro and nanocarriers.Microfluidic platforms offer several advantages over the conventional fabrication methods.Microfluidic devices hold great promise in controlling the physicochemical features of fabricated drug carriers.Micro and nanocarriers with controllable release kinetics and site-targeting efficiency can be fabricated.Drug carriers fabricated by microfluidic technology exhibited improved pharmacokinetic and pharmacodynamic profiles.

Aquatic food products (AFPs) are primarily preferred by consumers due to their high-quality protein content, omega 3 fatty acids, vitamins, minerals, and low calories. However, AFPs are easily degraded by microbial, enzymatic, and chemical reactions. The cold storage, freezing, chemical preservation, salting as well as vacuum packaging systems are the major preservation techniques. However, they are insufficient to extend the shelf life of AFPs. Therefore, researchers have focused on the availability of nanotechnology to be used in AFPs in line with the changing consumer demands. Studies on the effectiveness of nanoemulsion, nanoparticle, and nanofiber forms to increment the shelf life of AFPs are rapidly increasing. In this review, the degradation mechanisms of AFPs, the nano-preservation approaches, and possible mechanisms of action are reviewed with the current knowledge. The article highlights that nano-preservation approaches in AFPs have better microbial and physicochemical parameters such as total volatile basic nitrogen (TVBN), thiobarbituric acid (TBA), peroxide value (PV), free fatty acid (FFA), pH as well as the shelf life extension compared to the conventional methods. The antimicrobial activity of nanostructures reduces the microbial load of AFPs and delays the onset of oxidative degradation. Consequently, researchers suggest that nano-approaches may have great potential in extending the shelf life of AFPs.

Mucopolysaccharidosis type I (MPS I) is a rare monogenic disease in which glycosaminoglycans\' abnormal metabolism leads to the storage of heparan sulfate and dermatan sulfate in various tissues. It causes its damage and impairment. Patients with the severe form of MPS I usually do not live up to the age of ten. Currently, the therapy is based on multidisciplinary care and enzyme replacement therapy or hematopoietic stem cell transplantation. Applying gene therapy might benefit the MPS I patients because it overcomes the typical limitations of standard treatments. Nanoparticles, including nanoemulsions, are used more and more in medicine to deliver a particular drug to the target cells. It allows for creating a specific, efficient therapy method in MPS I and other lysosomal storage disorders. This article briefly presents the basics of nanoemulsions and discusses the current state of knowledge about their usage in mucopolysaccharidosis type I.

Thermal energy storage materials (TES) are considered promising for a large number of applications, including solar energy storage, waste heat recovery, and enhanced building thermal performance. Among these, nanoemulsions have received a huge amount of attention. Despite the many reviews published on nanoemulsions, an insufficient number concentrate on the particularities and requirements of the energy field. Therefore, we aim to provide a review of the measurement, theoretical computation and impact of the physical properties of nanoemulsions, with an integrated perspective on the design of thermal energy storage equipment. Properties such as density, which is integral to the calculation of the volume required for storage; viscosity, which is a decisive factor in pressure loss and for transport equipment power requirements; and thermal conductivity, which determines the heating/cooling rate of the system or the specific heat directly influencing the storage capacity, are thoroughly discussed. A comparative, critical approach to all these interconnected properties in pertinent characteristic groups, in close association with the practical use of TES systems, is included. This work aims to highlight unresolved issues from previous investigations as well as to provide a summary of the numerical simulation and/or application of advanced algorithms for the modeling, optimization, and streamlining of TES systems.

Increasing market pressure to reduce the use of antibiotics and the Veterinary Feed Directive of 2019 have led to expanded research on alternate antibiotic solutions. This review aimed to assess the benefits of using essential oils (EOs) and their nanoemulsions (NEs) as feed supplements for poultry and their potential use as antibiotic alternatives in organic poultry production. Antibiotics are commonly used to enhance the growth and prevent diseases in poultry animals due to their antimicrobial activities. EOs are a complex mixture of volatile compounds derived from plants and manufactured via various fermentation, extraction, and steam distillation methods. EOs are categorized into 2 groups of compounds: terpenes and phenylpropenes. Differences among various EOs depend on the source plant type, physical and chemical soil conditions, harvest time, plant maturity, drying technology used, storage conditions, and extraction time. EOs can be used for therapeutic purposes in various situations in broiler production as they possess antibacterial, antifungal, antiparasitic, and antiviral activities. Several studies have been conducted using various combinations of EOs or crude extracts of their bioactive compounds to investigate their complexity and applications in organic poultry production. NEs are carrier systems that can be used to overcome the volatile nature of EOs, which is a major factor limiting their application. NEs are being progressively used to improve the bioavailability of the volatile lipophilic components of EOs. This review discusses the use of these nonantibiotic alternatives as antibiotics for poultry feed in organic poultry production.