背景:僵硬人综合征(SPS)表现为进行性僵硬以及影响轴向和四肢肌肉的肌肉痉挛。1956年首次发现,其临床特征取得了重大进展,理解发病机理,以及有效的治疗方法。
方法:一名67岁的女性患者,有2年的进行性僵硬史,并伴有双腿疼痛性痉挛,前一年她的病情恶化,使她站立和行走相当困难。这里,我们报道了一例患有肺腺癌的僵人综合征(SPS)患者,抗谷氨酸脱羧酶(抗GAD)抗体阳性.激素和丙种球蛋白治疗改善了她的症状。此外,本文对SPS肿瘤患者进行了文献综述。
结论:自身免疫性SPS的诊断取决于临床,电生理学,以及免疫学发现。早期SPS检测对于防止长期残疾至关重要。
BACKGROUND: Stiff-person syndrome (SPS) manifests by progressive rigidity along with muscle spasms that affect the axial and limb muscles. First discovered in 1956, significant progress has been made in its clinical characterization, comprehension of pathogenesis, as well as effective treatment therapy.
METHODS: A 67-year old female patient presented with a 2-year history of progressive stiffness along with painful spasms in both legs, with her condition worsening over the previous year making it considerably difficult for her to stand and walk. Here, we report a Stiff-person syndrome patient (SPS) with lung adenocarcinoma who was positive for anti-glutamate decarboxylase (anti-GAD) antibodies. Treatment with hormones and gamma-globulin improved her symptoms. In addition, we present a literature review of SPS patients with tumors.
CONCLUSIONS: The diagnosis of autoimmune SPS was on the basis of clinical, electrophysiological, as well as immunological findings. Early SPS detection is critical to preventing long-term disability.