multidisciplinary collaboration

多学科协作
  • 文章类型: Journal Article
    探讨全科医生和物理治疗师对挪威初级保健中肌肉骨骼疾病患者的当前护理模式的看法,如果英国第一接触从业者模型,患者可以接触多个具有肌肉骨骼健康专业知识的专业团体,可以为服务发展提供信息。
    我们分析了对5位全科医生和11位物理治疗师的访谈,并利用利普斯基关于街头官僚主义的理论和福柯关于权力和制度结构机制的理论来探索任务转移和不同职业之间的合作。
    经验材料反映了关于初级保健中技能组合的多方面论述,其中财务因素,对能力的看法,任务偏好调节了对任务转移的态度。行业间的竞争与合作并存,历史霸权和新的护理模式之间似乎逐渐模糊,这既造成了联盟,也造成了竞争。与明智选择原则和循证实践的偏差的例子表明,全科医生和物理治疗师都平衡了患者倡导者的角色,看门人,和同质经济,在任务转移受到既定实践挑战的情况下。肌肉骨骼疾病患者的管理似乎是分散的,在某种程度上反映了供应驱动的系统。
    对初级保健的需求给全科医生带来了越来越大的压力。多学科团队合作有可能改善初级保健,对于医疗保健专业人员和患者。在这项研究中,看来,在初级保健中,全科医生和物理治疗师之间存在竞争和合作。挪威初级保健中肌肉骨骼疾病患者的服务提供有改变的情况。
    UNASSIGNED: To explore the views of general practitioners and physiotherapists on the current model of care for patients with musculoskeletal disorders in Norwegian primary care, and if the English First Contact Practitioner model, where patients have access to multiple professional groups with musculoskeletal health expertise, could inform service development.
    UNASSIGNED: We analysed interviews with five GPs and 11 physiotherapists and used Lipsky\'s theories about street-level bureaucracy and Foucault\'s theories of mechanisms of power and institutional structures to explore task shifting and cooperation between different professions.
    UNASSIGNED: The empirical material reflected a multi-faceted discourse about skill-mix in primary care, where financial factors, perceptions about competence, and task preferences moderated attitudes to task shifting. Competition and cooperation coexist between the professions, and the seemingly gradual blurring between historical hegemony and new models of care creates both alliances and rivalries. Examples of deviations from the Choosing Wisely principles and evidence-based practice indicate that both general practitioners and physiotherapists balance the roles of patient advocate, gatekeeper, and homo economicus, in a context where task shifting is challenged by established practice. It appears that the management of patients with musculoskeletal disorders is fragmented and to some extent reflects a supply-driven system.
    The demand on primary care is placing increasing pressure on general practitioners.Multidisciplinary teamwork has potential to improve primary care, for both healthcare professionals and for patients.In this study, it appeared that both competition and cooperation exist between general practitioners and physiotherapists around the management of patients with musculoskeletal disorders in primary care.There is a case for change in service delivery for patients with musculoskeletal disorders in Norwegian primary care.
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  • 文章类型: Journal Article
    不断增长的人口老龄化在维持他们的生活质量(QoL)方面提出了独特的挑战,其中包括物理,心理,和社会福祉。这项研究旨在评估多学科合作对接受初级保健的老年患者QoL的影响。进行了一项横断面研究,其中包括来自Al-Ahsa初级保健中心的200名60岁及以上的参与者,沙特阿拉伯,2024年3月至5月。使用标准化工具收集数据:SF-36用于与健康相关的QoL,多学科协作评估工具(MCET)和Lubben社交网络量表(LSNS)。进行了多元回归分析,以检查多学科合作之间的关联,社会支持,和QoL结果。多学科合作与身体功能改善呈显著正相关(β=2.35,p<0.001),心理健康(β=3.01,p<0.001),和一般健康感知(β=2.12,p<0.001)。有效合作的关键驱动因素包括有效沟通(β=0.48,p<0.001),配位(β=0.42,p<0.001),和患者受累(β=0.40,p<0.001)。社会支持,特别是来自朋友(β=0.33,p<0.001)和家庭(β=0.28,p<0.001),也是更好的QoL的稳健预测因子。年龄更小,女性性别,婚姻状况,没有慢性疾病与多学科护理带来的QoL改善有关.多学科合作和社会支持网络显着提高老年初级保健患者的QoL。医疗保健系统应优先考虑开发协作护理模式,培养跨学科团队合作,和整合战略,以促进人口老龄化的社会联系。
    The growing aging population presents unique challenges in maintaining their quality of life (QoL), which encompasses physical, psychological, and social wellbeing. This study aimed to assess the impact of multidisciplinary collaboration on QoL among older patients receiving primary care. A cross-sectional study was conducted involving a purposive sampling of 200 participants aged 60 years and above from Primary Healthcare Centers in Al-Ahsa, Saudi Arabia, between March and May 2024. Data were collected using standardized tools: SF-36 for health-related QoL, Multidisciplinary Collaboration Evaluation Tool (MCET), and Lubben Social Network Scale (LSNS). Multivariate regression analyses were performed to examine the associations between multidisciplinary collaboration, social support, and QoL outcomes. Multidisciplinary collaboration exhibited a significant positive association with improvements in physical functioning (β = 2.35, p < 0.001), mental health (β = 3.01, p < 0.001), and general health perceptions (β = 2.12, p < 0.001). Key drivers of effective collaboration included effective communication (β = 0.48, p < 0.001), coordination (β = 0.42, p < 0.001), and patient involvement (β = 0.40, p < 0.001). Social support, particularly from friends (β = 0.33, p < 0.001) and family (β = 0.28, p < 0.001), was also a robust predictor of better QoL. Younger age, female gender, married status, and absence of chronic conditions were associated with greater QoL improvements from multidisciplinary care. Multidisciplinary collaboration and social support networks significantly enhance QoL among older primary care patients. Healthcare systems should prioritize developing collaborative care models, fostering interdisciplinary teamwork, and integrating strategies to promote social connectedness for the aging population.
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  • 文章类型: Journal Article
    目的:描述中国儿童斜颈的疾病谱并改进其诊断流程图。
    方法:对2017-2021年北京儿童医院康复科进行回顾性分析。根据斜颈的诊断流程图对患者进行诊断和转诊。从门诊电子病历系统收集详细的患者数据。
    结果:共2047例患者符合纳入标准。前五名为先天性肌性斜颈(CMT)(76.6%),脑瘫(5.1%),眼斜颈(4.7%),臂丛神经损伤(1.9%)和寰枢椎旋转半脱位(1.3%)。CMT在0-2岁儿童中最常见,3-5岁的脑瘫,和7-12岁儿童的寰枢椎旋转半脱位。前五大转诊部门是骨科,眼科,耳鼻喉科,头颈部手术,神经病学和神经外科。
    结论:儿童斜颈的疾病谱和诊断流程图为斜颈的诊断提供了重要参考,这就需要多学科合作。
    OBJECTIVE: To describe the disease spectrum of torticollis in Chinese children and to improve its diagnostic flowchart.
    METHODS: A retrospective analysis was conducted at the Rehabilitation Department of Beijing Children\'s Hospital from 2017 to 2021. Patients were diagnosed and referred based on a diagnostic flowchart of torticollis. Detailed patient data were collected from the outpatient electronic medical record system.
    RESULTS: A total of 2047 patients met the inclusion criteria. The top five conditions were congenital muscular torticollis (CMT) (76.6%), cerebral palsy (5.1%), ocular torticollis (4.7%), brachial plexus injury (1.9%) and atlantoaxial rotary subluxation (1.3%). CMT was most common in 0-2 year olds, cerebral palsy in 3-5 year olds, and atlantoaxial rotary subluxation in 7-12 year olds. The top five referral departments were orthopaedics, ophthalmology, otolaryngology, head and neck surgery, neurology and neurosurgery.
    CONCLUSIONS: The disease spectrum of torticollis in children and the diagnostic flowchart provide important references for diagnosing torticollis, which necessitates multidisciplinary collaboration.
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  • 文章类型: Journal Article
    在过去的二十年里,恢复计划已经在国际上得到研究和实施。目标设定和多学科合作是重新能力的核心要素。不幸的是,有限的干预描述留下了关于它们如何在实践中应用以及如何实现用户设定的目标的问题。因此,医疗保健提供者和组织往往缺乏知识来实施和调整reablement根据他们的国家和地方背景。本研究旨在收集有关目标设定和成就的数据,以及重新启用服务内的多学科合作,以深入了解这些流程如何为重新启用实践提供信息,并探索挪威医疗保健专业人员的经验,新西兰,和荷兰。
    使用了定性的探索性设计,包括对来自三个国家的参与康复计划的20名医疗保健专业人员(护理和专职健康)的三次焦点小组访谈。考虑到性别的混合,采用了目的性抽样,年龄和教育水平。
    研究结果反映了医疗保健专业人员的经验和康复过程,包括三个主要主题:(1)目标设定过程;清楚地表明目标设定是康复的重要组成部分,并有助于更好地理解用户的动机;(2)目标设定对多学科合作的影响;促进社区意识,学习氛围,工作满意度和任务转移;以及(3)用于达到用户目标的行为改变技术,促进自我反省和改变用户的观点。
    这项研究提供了来自三个国家的宝贵见解。目标设定起着至关重要的作用,能够在不同的环境中实现有效的再实施。更具体地说,为了便于根据用户的需求定制重新启用计划,并通过促进信任来建立更有效的多学科协作,共同的愿景,并利用彼此的专业知识。然而,尽管人们认识到了恢复能力的重要性,据所有人报道,文化转变对用户来说是必要的,非正式护理人员以及医疗保健专业人员。
    UNASSIGNED: Over the last two decades, reablement programs have been studied and implemented internationally. Goal-setting and multidisciplinary collaboration are central elements of reablement. Unfortunately, limited intervention descriptions leave questions on how they are applied in practice and how goals set by the user are achieved. As a consequence, healthcare providers and organizations often lack knowledge to implement and align reablement to their national and local context. This study aimed to collect data on goal-setting and achievement, and multidisciplinary collaboration within reablement services to provide insight into how these processes inform reablement practice as well as to explore the experiences of healthcare professionals in Norway, New Zealand, and the Netherlands.
    UNASSIGNED: A qualitative exploratory design was used comprising three focus group interviews with 20 healthcare professionals (nursing and allied health) involved in reablement programs from the three countries. Purposive sampling was employed considering a mix of gender, age and educational level.
    UNASSIGNED: Findings reflected healthcare professionals\' experiences and reablement processes in three main themes: (1) Goal-setting processes; clearly demonstrating goal-setting as an essential part of reablement and contributing to better understanding of users\' motives; (2) Impact of goal-setting on multidisciplinary collaboration; promoting a sense of community, learning climate, job satisfaction and task-shifting; and (3) Behavior change techniques used to reach users\' goals, promoting self-reflection and changing users\' perspectives.
    UNASSIGNED: This study offers valuable insights from three countries. Goal-setting serves a crucial role enabling effective reablement implementation across diverse contexts. More specifically, to facilitate tailoring of reablement programs to the user\'s needs as well as establish more effective multidisciplinary collaboration by promoting trust, shared vision, and utilizing each other\'s expertise. However, despite the acknowledgement of the significance of reablement, it was reported by all that a cultural shift is necessary for users, informal caregivers as well as healthcare professionals.
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  • 文章类型: Journal Article
    背景:吸入性肺炎复发率高,牙医的口腔护理可有效预防其发作;然而,这尚未通过前瞻性研究进行评估.因此,我们进行了一项前瞻性研究,以评估由牙医进行专业口腔护理在减少老年患者吸入性肺炎复发方面的效果.
    方法:在这项前瞻性队列研究中,我们评估了牙科口腔护理干预,使用历史控制组(对照组)。它是在日本的一家单中心区域核心医院进行的,该医院为大量80岁以上的患者提供服务。本研究包括因吸入性肺炎住院的患者。在研究期间(2021年4月1日至2022年3月31日),从2020年4月1日至2021年3月31日,临床组接受牙医每周的专业清洁,对照组接受护士照常的标准口腔护理.牙医口腔护理组每周接受牙医的专业口腔护理,并前瞻性随访1年。Kaplan-Meier分析用于评估复发性吸入性肺炎或死亡的时机。使用Cox比例风险模型获得风险比并确定95%置信区间。
    结果:临床组91例,对照组94例。参与者的平均年龄是85岁,75(40.5%)为女性。临床组复发率为27.5%,对照组为44.7%(P=0.005)。由牙医进行专业清洁可将吸入性肺炎复发的风险降低约50%(调整后的危险比,0.465;95%置信区间,0.278-0.78)。
    结论:与护士提供的常规口腔护理相比,牙医的专业清洁与吸入性肺炎复发率较低相关。
    BACKGROUND: Aspiration pneumonia has a high recurrence rate, and oral care by dentists has been found effective in preventing its onset; however, this has not been evaluated using prospective studies. Therefore, we conducted a prospective study to evaluate the effectiveness of professional oral care by dentists in reducing aspiration pneumonia recurrence in older adult patients.
    METHODS: In this prospective cohort study, we evaluated a dental oral care intervention, using a historical control group (control group). It was conducted at a single-centre regional core hospital in Japan that serves a large number of patients aged older than 80 years. Patients who were hospitalised for aspiration pneumonia were included in this study. During the study period (1 April 2021 to 31 March 2022), the clinical group received weekly professional cleaning by a dentist and the control group received standard oral care by a nurse as usual from 1 April 2020 to 31 March 2021. The dentist oral care group received weekly professional oral care from a dentist and was followed prospectively for 1 year. A Kaplan-Meier analysis was used to evaluate the timing of recurrent aspiration pneumonia or death. A Cox proportional hazards model was used to obtain a hazard ratio and determine the 95% confidence intervals.
    RESULTS: There were 91 participants in the clinical group and 94 in the control group. The mean age of participants was 85 years, and 75 (40.5%) were female. The recurrence rate was 27.5% in the clinical group and 44.7% in the control group (P = .005). Professional cleaning by a dentist reduced the risk of recurrence of aspiration pneumonia by approximately 50% (adjusted hazard ratio, 0.465; 95% confidence interval, 0.278-0.78).
    CONCLUSIONS: Professional cleaning by a dentist was associated with a lower rate of aspiration pneumonia recurrence than nurse-provided conventional oral care.
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  • 文章类型: Journal Article
    背景:在电子健康研究中与不同利益相关者的合作是基础但复杂的。来自不同学科的利益相关者不会“说同一种语言”,并且具有不同程度的权力和兴趣,导致不同的目标,优先事项,和期望。为了克服这种复杂的动态,必须采取建设性的沟通和合作方法。共同创造,在eHealth领域最常涉及最终用户,也可能适合促进利益相关者的参与和对齐。
    目的:本文提供了对共同创造应用的见解,特别是在研究的早期阶段,专注于参与和调整来自不同学术和专业背景的相关利益相关者。
    方法:本研究的案例是与多学科联盟成员的小组讨论,该联盟致力于开发动脉粥样硬化性心血管疾病的个性化电子健康干预措施。使用利益相关者映射,健康和医学专家,大数据科学家,软件开发人员,邀请了一名创新经理(N=8)参加。该讨论基于用户场景,并根据deBono的六顶思考帽进行了结构化,代表6种不同类型的思维。讨论被记录下来,逐字转录,并使用ATLAS进行主题分析。ti软件。
    结果:首先,信息和直观的思维有助于熟悉项目细节和其他参与者。第二,积极和批判性的思维构成了讨论的主体,并导致了深入的对话。第三,创造性和组织思维以行动为导向,侧重于解决方案和规划,以保障未来的进步。与会者反复思考各种与干预有关的主题,从干预内容到技术功能,从法律要求到实践实施。此外,讨论了与项目有关的事项,包括利益相关者管理以及时间和预算限制。
    结论:本文展示了共同创造如何对多学科利益相关者的参与和协调具有价值。基于利益相关者映射(与谁讨论),一个梦想的用户场景(讨论什么),和德博诺的六顶思考帽(如何讨论),参与者分享了信息,讨论差异,寻找解决方案,并转向关于干预发展的集体方法。吸取的经验教训可以进一步增进对共同创造如何有助于多学科合作的理解。
    Collaboration with diverse stakeholders in eHealth research is fundamental yet complex. Stakeholders from various disciplines do not \"speak the same language\" and have different levels of power and interest, resulting in contrasting objectives, priorities, and expectations. An approach to constructive communication and collaboration is necessary to overcome this complex dynamic. Cocreation, known in the field of eHealth most often to involve end users, may also be suitable for facilitating stakeholder engagement and alignment.
    This paper provides insights into the application of cocreation, specifically in the early phases of research that focus on involving and aligning relevant stakeholders from different academic and professional backgrounds.
    The case for this study was a group discussion with members of a multidisciplinary consortium that works on developing a personalized eHealth intervention for atherosclerotic cardiovascular disease. Using stakeholder mapping, health and medicine experts, big data scientists, software developers, and an innovation manager (N=8) were invited to participate. The discussion was based on a user scenario and structured according to the Six Thinking Hats of de Bono, representing 6 different types of thinking. The discussion was recorded, transcribed verbatim, and analyzed thematically with the use of ATLAS.ti software.
    First, informative and intuitive thinking served the preparatory purpose of familiarization with the project details and other participants. Second, positive and critical thinking constituted the body of the discussion and resulted in an in-depth conversation. Third, creative and organizational thinking were action oriented and focused on solutions and planning to safeguard future progress. The participants repeatedly reflected on various intervention-related themes, ranging from intervention content to technical functionalities and from legal requirements to implementation in practice. Moreover, project-related matters were discussed, including stakeholder management and time and budget constraints.
    This paper demonstrates how cocreation can be of value for multidisciplinary stakeholder engagement and alignment. Based on stakeholder mapping (with whom to discuss), a dream user scenario (what to discuss), and the Six Thinking Hats of de Bono (how to discuss), the participants shared information, discussed differences, searched for solutions, and moved toward a collective approach regarding intervention development. The lessons learned may further improve the understanding of how cocreation can contribute to multidisciplinary collaboration.
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  • 文章类型: Journal Article
    营养不良对健康有重要影响,尤其是老年人。口服营养补充剂(ONS)是帮助平衡营养不良者营养需求的有效策略。社区药房提供多个ONS,使药剂师有可能实施预防和监测营养不良患者的策略。这项研究的目的是通过ONS使用者的咨询和随访来描述社区药剂师的经验。采访了来自19个不同社区药房的19名药剂师。除了分发ONS以支持正在准备诊断测试的患者外,ONS咨询最常提及的临床病症是营养不良和吞咽困难.当药剂师考虑分配ONS时,出现了三个主题:病人护理,与根据每个患者的需求量身定制的ONS咨询相关;跨专业合作,特别关注与注册营养师的合作;以及ONS的培训和教育,希望提高他们在ONS咨询和后续行动中的知识和技能。未来的研究探索药剂师和营养师之间在这种情况下的新形式的互动应该发展,旨在确定跨学科服务的工作流程,以满足社区营养不良患者的需求。
    Malnutrition has important health impacts, especially in the elderly. Oral nutritional supplements (ONS) are effective strategies to help balance the nutritional needs of malnourished persons. Multiple ONS are available at community pharmacies, enabling pharmacists to have the possibility to implement strategies for prevention and monitoring of malnourished patients. The aim of this study was to characterize the experience of community pharmacists with the counseling and follow-up of users of ONS. A sample of 19 pharmacists from 19 different community pharmacies were interviewed. Apart from dispensing ONS to support patients that are preparing for diagnostic tests, the most frequently mentioned clinical condition for ONS counseling was malnutrition and dysphagia. When pharmacists consider dispensing ONS, three themes emerge: patient care, related to counselling tailored ONS to each patient\'s needs; interprofessional collaboration, with a special focus in the collaboration with registered dietitians; and training and education on ONS, looking to improve their knowledge and skills in ONS counselling and follow-up. Future studies exploring new forms of interaction between pharmacists and dietitians in this context should be developed, aiming to determine the workflow of an interdisciplinary service addressing the needs of community dwelling malnourished patients.
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  • 文章类型: Journal Article
    对住院患者进行牙科护理可以改善营养状况和喂养功能,同时减少并发症的发生。然而,在日本,这种护理并不是统一提供的。这项调查检查了牙医工作的医院的存在和特征以及医疗和牙科团队之间的合作。这项横断面研究涉及7205家医院,使用2018年医院病床功能的行政报告。所描述的指标是医院雇用牙医的比例,那些提供围手术期口腔护理的人,以及那些拥有包括牙医在内的营养支持团队(NST)的人。使用基于医院和基于二级医疗领域的因素进行了两级逻辑回归模型,以确定与雇用牙医和牙科护理服务的医院相关的因素。一些医院的医疗和牙科合作不佳,即使是那些有牙医的人,没有牙医的医院有罕见的医疗和牙科合作。与雇用牙医的医院呈正相关的因素是诊断-程序-组合-医院类型,日本政府建立的医院与公共组织建立的医院相比,在其他人中。总之,本研究发现,在一些医院和医院类型中观察到医疗和牙科合作不佳,区域,和医院创始人与协作医疗和牙科护理的表现有关。
    Dental care for hospitalized patients can improve nutritional status and feeding function while reducing complications. However, such care in Japan is not uniformly provided. This investigation examined the presence and characteristics of hospitals where dentists work and the collaboration between medical and dental teams. This cross-sectional study involves 7205 hospitals using the administrative reports on the Hospital Bed Function of 2018. Indicators described were the proportion of hospitals employing dentists, those providing perioperative oral care, and those with a nutrition support team (NST) that included dentists. A two-level logistic regression model was performed using hospital-based and secondary medical area-based factors to identify factors associated with hospitals employing dentists and dental care services. Some hospitals had poor medical and dental collaboration, even those with dentists, and no-dentist hospitals had rare medical and dental collaboration. Factors positively associated with hospitals that employed dentists were diagnosis-procedure-combination-hospital types, the Japanese government-established hospitals compared with hospitals established by public organizations, among others. In conclusion, the present study found poor medical and dental collaboration was observed in some hospitals and that hospital type, region, and hospital founders were associated with the performance of collaborative medical and dental care.
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  • 文章类型: Journal Article
    背景:这项研究旨在回顾多个中心的结直肠癌肝转移(CRLM)患者,以分析影响CRLM最初被评估为可能可切除的患者转换治疗成功的因素,探讨不同治疗方法对患者生存的影响,为临床治疗CRLM提供科学参考。
    方法:这项回顾性研究纳入了50例患者,他们的CRLM最初在中国3家大型综合医院被评估为可能可切除。对一般数据和病理特征数据进行统计分析,以检查治疗方法的临床疗效。采用logistic回归分析影响转化治疗成功的因素。此外,进行后续预约以检查生存,并使用Kaplan-Meier估计器绘制生存曲线。分析不同临床病理特点对CRLM患者的影响。
    结果:17例患者在接受转换治疗后通过手术切除/消融术未达到疾病(NED)状态。多因素分析显示,肝转移灶数目是影响转阴治疗疗效的主要危险因素(P<0.05)。生存分析结果显示,NED组与不显眼/进展组之间的总生存(OS)差异有统计学意义(P<0.0001)。此外,NED组与不明显/进展组的无进展生存期(PFS)差异有统计学意义(P<0.0001).手术切除组的OS和PFS均优于消融组(P<0.0001和P<0.01)。单因素分析表明,肝转移瘤的数量和最大直径,血清Carcino-胚胎抗原(CEA)水平,和BRAFV600E突变状态是影响CRLM患者OS的因素(P<0.05),其中BRAFV600E突变是主要决定因素(P<0.05)。
    结论:在CRLM最初被评估为不可切除的患者中,在接受转化治疗后接受手术切除原发灶和肝转移的患者预后最佳.因此,应进行全面评估,以确定在肝转移瘤治疗中转化治疗的效果和影响生存因素。
    BACKGROUND: This study sought to review colorectal cancer liver metastasis (CRLM) patients at multiple centers to analyze the factors affecting the success of conversion therapy in patients whose CRLM was initially evaluated as potentially resectable, to explore the effect of different treatment approaches on patient survival, and to provide a scientific reference for clinical treatment of CRLM.
    METHODS: Fifty patients whose CRLM was initially evaluated as potentially resectable at 3 large Chinese general hospitals were enrolled in this retrospective study. Statistical analyses were carried out on the general data and pathological characteristic data to examine the clinical efficacy of the treatment approaches. The factors affecting the success of conversion therapy were analyzed by logistic regression. Additionally, follow-up appointments were conducted to examine survival, and survival curves were plotted using the Kaplan-Meier estimator. The effect of different clinical and pathological characteristics on CRLM patients was analyzed.
    RESULTS: Seventeen patients achieved no evidence of disease (NED) status through surgical resection/ablation after undergoing conversion therapy. The multifactor analysis demonstrated that the number of liver metastases was the primary risk factor affecting the efficacy of conversion therapy (P<0.05). Survival analysis results showed statistically significant difference in overall survival (OS) between the NED group and the inconspicuous/progressive group (P<0.0001). Also, there was a statistically significant difference in the progression-free survival (PFS) between the NED group and the inconspicuous/progressive group (P<0.0001). Patients in the surgical resection group had better OS and PFS than those in the ablation group (P<0.0001 and P<0.01, respectively). The monofactor analysis demonstrated that the number and maximum diameter of liver metastases, serum Carcino-Embryonic Antigen (CEA) level, and BRAF V600E mutation status were factors affecting the OS of CRLM patients (P<0.05), of which BRAF V600E mutation was the primary determinant (P<0.05).
    CONCLUSIONS: Among the patients whose CRLM was initially evaluated as unresectable, those who underwent surgical resection of the primary lesions and liver metastases after receiving conversion therapy had the best prognosis. Thus, a thorough evaluation should be conducted to determine the effect of and survival factors affecting conversion therapy in the treatment of liver metastases.
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  • 文章类型: Clinical Trial Protocol
    一般来说,在怀孕期间,女性意识到良好饮食质量的重要性,对营养感兴趣,并接受改变饮食摄入量。然而,坚持饮食指南是次优的。孕妇关于营养信息的第一个信息来源是她的助产士。因此,助产士促进健康营养可能非常有希望,但是助产士在提供营养支持方面面临多重障碍。增强孕妇改善饮食质量的能力有望改善她们的健康状况。因此,已经开发了一种赋权干预措施来改善孕妇的饮食质量。这项研究的目的是评估Power4a健康妊娠(P4HP)的有效性和可行性。P4HP旨在使孕妇拥有更健康的饮食质量。
    本研究采用混合方法,包括干预组(P4HP)和对照组的非盲整群随机试验以及过程评估。助产实践,集群,将随机分配到干预臂(n=7)和控制臂(n=7)。参与的妇女根据其助产实践被置于干预或控制条件下。每个助产实践包括25名孕妇,共有350名参与者。健康相关结果,饮食质量,赋权,连贯的感觉,生活质量,参与者的自测健康将在干预之前(T0)和之后(T1)进行评估。过程评估侧重于多学科合作,主持人,和障碍,包括对助产士的深入采访,营养师和孕妇。
    这项研究是首次评估赋权干预措施,以改善该目标人群的饮食质量。这种混合方法评估将有助于了解饮食质量的有效性和可行性,赋权,与健康相关的结果,多学科合作,赋权干预P4HP的促进者和障碍。结果将有助于告知助产士和营养师如何授权孕妇改善饮食质量。如果证明有效,P4HP有可能在全国范围内实施,并扩大到从孕前到产后阶段的长期轨迹。
    该试验在荷兰试验登记册(NL9551)中进行了前瞻性登记。注册日期:2021年5月19日。
    In general during pregnancy, women are aware of the importance of good diet quality, interested in nutrition, and receptive to changing dietary intake. However, adherence to dietary guidelines is sub-optimal. A pregnant woman\'s first information source regarding nutrition information is her midwife. Healthy nutrition promotion by midwives may therefore be very promising, but midwives face multiple barriers in providing nutritional support. Empowering pregnant women to improve their diet quality is expected to improve their health. Therefore an empowerment intervention has been developed to improve diet quality among pregnant women. The objective of this study is to evaluate the effectiveness and feasibility of Power 4 a Healthy Pregnancy (P4HP). P4HP aims to empower pregnant women to have a healthier diet quality.
    This study applies a mixed methodology consisting of a non-blinded cluster randomized trial with an intervention (P4HP) group and a control group and a process evaluation. Midwifery practices, the clusters, will be randomly allocated to the intervention arm (n = 7) and control arm (n = 7). Participating women are placed in intervention or control conditions based on their midwifery practice. Each midwifery practice includes 25 pregnant women, making 350 participants in total. Health related outcomes, diet quality, empowerment, Sense of Coherence, Quality of Life, and Self-Rated Health of participants will be assessed before (T0) and after (T1) the intervention. The process evaluation focuses on multidisciplinary collaboration, facilitators, and barriers, and consists of in-depth interviews with midwives, dieticians and pregnant women.
    This study is the first to evaluate an empowerment intervention to improve diet quality in this target population. This mixed method evaluation will contribute to knowledge about the effectiveness and feasibility regarding diet quality, empowerment, health-related outcomes, multidisciplinary collaboration, facilitators and barriers of the empowerment intervention P4HP. Results will help inform how to empower pregnant women to achieve improved diet quality by midwives and dieticians. If proven effective, P4HP has the potential to be implemented nationally and scaled up to a long-term trajectory from preconception to the postnatal phase.
    The trial is prospectively registered at the Netherlands Trial Register ( NL9551 ). Date registered: 19/05/2021.
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