三萜酸是具有广泛生物活性的植物化合物,其已成为许多体外和体内研究的主题。然而,它们在各种病理中的潜在作用机制尚未完全阐明。本综述旨在总结最新文献,在过去的五年里,关于三种三萜酸(积雪草酸,齐墩果酸,和熊果酸),与不同的生物活性相关,如抗癌,抗炎,抗糖尿病药,心脏保护,神经保护,保肝,和抗菌。所有三个讨论的化合物都有几种作用机制,例如PI3K/AKT的目标调制,Nrf2,NF-kB,EMT,和JAK/STAT3信号通路,虽然其他机制被证明只对部分三萜酸有特异性,比如Notch的调制,河马,和MALAT1/miR-206/PTGS1信号通路,也突出了。本文是我们关于这一主题的文献研究的第一部分,接下来是第二部分,重点介绍具有治疗价值的其他三萜酸。
Triterpenic acids are phytocompounds with a widespread range of biological activities that have been the subject of numerous in vitro and in vivo studies. However, their underlying mechanisms of action in various pathologies are not completely elucidated. The current
review aims to summarize the most recent literature, published in the last five years, regarding the mechanism of action of three triterpenic acids (asiatic acid, oleanolic acid, and ursolic acid), corelated with different biological activities such as anticancer, anti-inflammatory, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, and antimicrobial. All three discussed compounds share several mechanisms of action, such as the targeted modulation of the PI3K/AKT, Nrf2, NF-kB, EMT, and JAK/STAT3 signaling pathways, while other mechanisms that proved to only be specific for a part of the triterpenic acids discussed, such as the modulation of Notch, Hippo, and MALAT1/miR-206/PTGS1 signaling pathway, were highlighted as well. This paper stands as the first part in our literature study on the topic, which will be followed by a second part focusing on other triterpenic acids of therapeutic value.