Abstract：
Primary cilia are hair‑like organelles that are present on the majority of mammalian cells. They are regarded as the regulatory \'hub\' of cell functions due to their indispensable roles for several signaling pathways, such as Hh and Wnt pathways. Originally, cilia defects were found to cause a panoply of human diseases commonly referred to as \'ciliopathies\'. Evidence is accumulating that cilia defects are involved in the onset and development of cancer. Some proteins that cause cilia defects have been identified as oncogenes in multiple cancer types. Hence, understanding the pathways that cause cilia defects in cancer is of utmost importance for the development of novel cancer therapeutic targets. The present review article provides a critical overview of the molecular targets of primary cilia defects in cancer, and highlights their vast potential as therapeutic targets and novel biomarkers.
摘要：
初级纤毛是存在于大多数哺乳动物细胞上的毛发样细胞器。由于它们对几种信号通路不可或缺的作用，它们被认为是细胞功能的调节中心，如Hh和Wnt通路。最初,发现纤毛缺陷会导致一系列人类疾病，通常称为“纤毛病”。越来越多的证据表明，纤毛缺陷与癌症的发生和发展有关。一些导致纤毛缺陷的蛋白质已被鉴定为多种癌症类型的癌基因。因此，了解导致癌症纤毛缺陷的途径对于开发新的癌症治疗靶标至关重要。本综述文章提供了癌症中原发性纤毛缺陷的分子靶标的关键概述，并突出了它们作为治疗靶点和新型生物标志物的巨大潜力。
