背景:人参(PanaxginsengMeyer)是一种栽培的药草,自上个世纪以来已在亚洲地区广泛使用。人参根在世界范围内用于东方医学。目前,肺癌和炎症的全球死亡率和感染率正在显著增加。因此,与人参皂苷活性相关的各种预防方法已用于肺癌和炎症。
方法:在WebofScience上进行基于Web的搜索,Springer,PubMed,还有Scopus.还进行了癌症统计分析,以显示全世界受影响的病例和肺癌死亡的当前比率。
结果:人参皂苷调节参与肿瘤生长和迁移的酶,如核因子κB(NF-κB),丝裂原活化蛋白激酶(p38MAPK),c-Jun氨基末端激酶(JNK),细胞外信号调节激酶1/2(ERK1/2),明胶酶网络金属蛋白酶-2(MMP-2/9)和激活蛋白1(AP-1)。此外,人参皂苷还具有抗炎作用,通过抑制促炎细胞因子(肿瘤坏死因子-α)(TNF-α)和白细胞介素-1β(IL-1β)的形成,并控制炎症信号通路的活性,如NF-κB,Januskinase2/信号传感器,和转录激活因子3(Jak2/Stat3)。
结论:在一些体外和体内模型中,人参在肺癌和炎症治疗中显示出潜在的有益作用。在这次审查中,我们对人参皂苷的抗肺癌和抗炎保护作用及其潜在分子机制的研究证据进行了详细和最新的总结。
Ginseng (Panax ginseng Meyer) is a cultivated medicinal herb that has been widely available in the Asian region since the last century. Ginseng root is used worldwide in Oriental medicine. Currently, the global mortality and infection rates for lung cancer and inflammation are significantly increasing. Therefore, various preventative methods related to the activity of ginsenosides have been used for lung cancer as well as inflammation.
Web-based searches were performed on Web of Science, Springer, PubMed, and Scopus. A cancer statistical analysis was also conducted to show the current ratio of affected cases and death from lung cancer around the world.
Ginsenosides regulate the enzymes that participate in tumor growth and migration, such as nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (p38 MAPK), c-Jun N-terminal kinase (JNK), extracellular signalregulated kinases 1/2 (ERK1/2), the gelatinase network metalloproteinase-2 (MMP-2/9) and activator protein 1 (AP-1). In addition, ginsenosides also possess anti-inflammatory effects by inhibiting the formation of proinflammatory cytokines (tumor necrosis factor-α) (TNF-α) and interleukin-1β (IL-1β) and controlling the activities of inflammatory signalling pathways, such as NF-κB, Janus kinase2/signal transducer, and activator of transcription 3 (Jak2/Stat3).
In several in vitro and in vivo models, P. ginseng showed potential beneficial effects in lung cancer and inflammation treatment. In this
review, we provide a detailed and up-to-date summary of research evidence for antilung cancer and anti-inflammatory protective effects of ginsenosides and their potential molecular mechanisms.