miR-149是一种在癌变过程中具有重要作用的miRNA。该miRNA由2q37.3上的MIR149基因编码。miR-149发夹产生miR-149-5p和miR-149-3p,这是“指南”和“乘客”姐妹，分别。深度测序实验显示，与miR-149-3p相比，miR-149-5p的患病率更高。值得注意的是,已经报道了miR-149-5p的致癌和肿瘤抑制作用。在这次审查中,我们总结了miR-149-5p在肿瘤发生中的影响，并阐述了其在多种肿瘤条件下参与这一过程的机制。即，在体外，在体内和临床设置。
miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the \"guide\" and the sister \"passenger\" strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this
review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.
