葡萄膜黑色素瘤(UM)是一种眼内恶性肿瘤,由于转移扩散的倾向,存活率低。尽管存在局部疾病的治疗选择,转移性UM的明确指南较少。治疗涉及个性化的方法,需要患者特定的方面,包括肿瘤遗传学.此病例突显了一名60岁男性诊断为IIB期右眼脉络膜黑色素瘤的病程。尽管局部UM治疗成功,他发展了广泛的转移。他接受了双重免疫疗法,并最终维持在单一药物治疗方案。他的预后超过了最初的预后和生存预期。这个案例突出了免疫疗法的使用,双重和单一疗法,治疗这种罕见的恶性肿瘤并延长总生存期。
Uveal melanoma (UM) is an intraocular malignancy with poor survival rates due to the propensity for metastatic spread. Although treatment options exist for localized disease, there are fewer definitive guidelines for metastatic UM. Treatment involves a personalized approach that entails patient-specific aspects, including tumor genetics. This
case highlights the disease course of a 60-year-old male diagnosed with stage IIB right eye choroidal melanoma. Despite successful therapy for localized UM, he developed widespread metastasis. He received dual immunotherapy and was ultimately maintained on a single-agent regimen. His prognosis has surpassed initial prognosis and survival expectations. This
case highlights the use of immunotherapy, both dual and single therapy, to treat this rare malignancy and extend overall survival.