■腺癌是宫颈癌的一种常见组织学亚型,占所有病例的10-15%。宫颈腺癌伴远处器官转移的预后尚不清楚。因此,本研究旨在探讨宫颈腺癌远处器官转移的规律和预后。
■我们从监视中获得了数据,流行病学,和2010年至2019年的最终结果(SEER)数据库。Cox回归,Kaplan-Meier,并进行了对数秩分析。
■我们观察到子宫颈腺癌(AC)主要转移到单个器官,率为73.3%。肺是最常见的转移器官,其次是肝脏和骨骼。骨转移患者的中位生存期为12个月,与其他器官的转移相比,时间稍长。远处器官转移,年龄,阳性淋巴结,更高的AJCC阶段,肿瘤直径较大,和较高的细胞等级与不良预后相关(p<0.001)。此外,我们观察到手术干预,放射治疗,和化疗可以为远处器官转移患者提供潜在的益处。
■转移是宫颈腺癌患者的独立预后因素。手术,放射治疗,化疗可以为远处器官转移患者提供总体生存优势。
UNASSIGNED: Adenocarcinoma is a common histological subtype of cervical cancer, accounting for 10-15% of all cases. The prognosis of cervical adenocarcinoma with distant organ metastases remains unclear. Therefore, our
study aimed to investigate the patterns and prognosis of distant organ
metastasis in cervical adenocarcinoma.
UNASSIGNED: We obtained data from the Surveillance, Epidemiology, and End Results (SEER) database spanning from 2010 to 2019. Cox regression, Kaplan-Meier, and log-rank analyses were conducted.
UNASSIGNED: We observed that adenocarcinoma (AC) of the cervix primarily metastasizes to single organs, with a rate of 73.3%. The lungs are the most common organs of
metastasis, followed by the liver and bones. Patients with bone metastases have a median survival period of 12 months, which is slightly longer compared to
metastasis in other organs. Distant organ
metastasis, age, positive lymph nodes, higher AJCC stages, larger tumor diameter, and higher cell grades are related to poor prognosis (p < 0.001). Furthermore, we have observed that surgical intervention, radiotherapy, and chemotherapy can potentially provide benefits for patients with distant organ metastases.
UNASSIGNED: Metastasis is an independent prognostic factor for cervical adenocarcinoma patients. Surgery, radiotherapy, and chemotherapy can provide an overall survival advantage for patients with distant organ metastases.