背景和目的:呼吸器,通常受肺癌和间皮瘤等高度侵袭性肿瘤的影响,很少受原发性恶性黑色素瘤的影响。这篇综述的目的是确定现代科学文献中发表的原发性肺恶性黑色素瘤(PMML)的病例,并描述他们的主要临床,病理和治疗特征。材料和方法:已使用关键字对电子数据库PubMed中的出版物进行了系统搜索,并检查所选文章的参考文献,以确定其他缺失的研究。结果:全球共有52篇报告76例的论文。其中一宗个案有47宗报告,三篇论文分别报道了两个案例,1997年和2005年出版的两个较大的案例系列,包括8个和15个案例,分别。结论:PMML一般在中年男性中诊断,与吸烟没有任何明显的相关性。它更常见于下叶和左肺。肿瘤通常是色素沉着的,由上皮和/或梭形细胞组成,具有大的细胞核和突出的核仁,核非典型性,和许多有丝分裂图;它们通常显示S-100,HMB45和Melan-A的免疫染色。早期发现和手术切除是这种罕见恶性肿瘤生存的主要决定因素。
Background and Objectives: The respiratory apparatus, generally affected by highly aggressive tumors like lung cancer and mesothelioma, is rarely affected by primary malignant melanoma. The aim of this
review was to identify cases of primary malignant melanoma of the lung (PMML) published in the modern scientific literature, and to describe their main clinical, pathological and therapeutic features. Materials and Methods: A systematic search of publications in the electronic database PubMed has been performed using keywords, and the references of the selected articles were checked to identify additional missing studies. Results: Globally 52 papers reporting on 76 cases were identified. Among them there were 47 reports of a single case, three papers reporting on two cases each, and two larger case series published in 1997 and 2005 including eight and 15 cases, respectively. Conclusions: PMML was generally diagnosed in middle-aged males, without any apparent correlation with cigarette smoking. It was more frequently found in the lower lobes and the left lung. The tumors were generally pigmented, composed by epithelial and/or spindle cells with large nuclei and prominent nucleoli, nuclear atypia, and numerous mitotic figures; they commonly showed immunostaining for S-100, HMB 45 and Melan-A. Early detection and surgical resection were the main determinants of survival from this rare malignancy.