口腔和口咽鳞状细胞癌(OOPSCC)患者的牙科治疗对于牙医来说可能具有挑战性。这项研究旨在描述在癌症治疗之前接受牙科治疗的OOPSCC患者的全身性变化。特别关注实验室评估。主要目标包括识别潜在的不良事件,如感染或出血,由于牙科手术。此外,本研究旨在将基线患者特征与治疗相关毒性相关.这是一项前瞻性队列研究,包括110名OOPSCC患者,他们转诊到圣保罗州立癌症研究所的牙科肿瘤服务机构,巴西,2019年11月至2020年12月。合并症,社会人口统计数据,使用中的药物,癌症治疗相关的毒性,和改变的实验室测试结果是相关的。最常见的合并症和实验室检查结果的改变是高血压,血脂异常,糖尿病,以及C反应蛋白水平升高,血红蛋白,和血细胞比容.毒性随着时间的推移表现出渐进的模式,包括口腔粘膜炎(OM),口干症,吞咽困难,熟食症,刺耳,和放射性皮炎。合并症和癌症治疗相关毒性之间没有相关性,使用的药物与OM之间存在正相关,并且发现药物和味觉障碍之间存在负相关。OM与甲状腺素(T4)和游离甲状腺素(FT4)改变有关,钙,尿素,肌酐,碱性磷酸酶,还有梅毒.家庭收入和住房是OM预测因素。改变T4/FT4/尿素/钙/碱性磷酸酶/肌酐/梅毒可能是OM的有用临床预测因子。尽管合并症和异常实验室检查结果的患病率上升,癌症治疗前的牙科治疗未产生不良事件.
The dental treatment of patients with oral cavity and oropharyngeal squamous cell carcinoma (OOPSCC) may be challenging for dentists. This
study aimed to characterize systemic changes in patients with OOPSCC undergoing dental treatment prior to cancer therapy, with a specific focus on laboratory assessments. The primary objectives included identifying potential adverse events, such as infections or bleeding, resulting from dental procedures. Additionally, the
study aimed to correlate baseline patient characteristics with treatment-related toxicities. This was a prospective cohort
study that included 110 OOPSCC patients referred to the Dental Oncology Service at São Paulo State Cancer Institute, Brazil, between November/2019 and December/2020. Comorbidities, sociodemographic data, medication in use, cancer treatment-related toxicities, and altered laboratory tests results were correlated. The most common comorbidities and altered laboratory results were hypertension, dyslipidemia, diabetes, as well as elevated levels of C-reactive protein, hemoglobin, and hematocrit. Toxicities exhibited a progressive pattern over time, encompassing oral mucositis (OM), xerostomia, dysphagia, dysgeusia, trismus, and radiodermatitis. No correlation between comorbidities and cancer treatment-related toxicities, a positive correlation between medications in use and OM, and a negative correlation between medications and dysgeusia were found. OM was associated with altered thyroxine (T4) and free thyroxine (FT4), calcium, urea, creatinine, alkaline phosphatase, and syphilis. Family income and housing were OM predictors. Altered T4/FT4/urea/calcium/alkaline phosphatase/creatinine/syphilis may be useful clinical predictors of OM. Despite the elevated prevalence of comorbidities and abnormal laboratory findings, dental treatment prior to cancer treatment yielded no adverse events.