细胞和组织的僵硬度在一段时间内被认为有助于发育和病理信号。但是潜在的机制仍然难以捉摸。整合素及其相关的粘附信号复合物(IACs),它们在细胞骨架和细胞外基质之间形成了联系,充当细胞中的关键力传感和转换单元。因此,人们对获得对IAC组成的系统级理解非常感兴趣。蛋白质组学方法揭示了IAC的复杂性,并鉴定了大量受细胞骨架力调节的成分。在这里,我们回顾了共识坚持的功能,从多个蛋白质组数据集的荟萃分析中出现的核心IAC蛋白的集合,在机械传感的背景下。由于IAC成分与涉及刚性传感的多种疾病有关,该领域现在可以定义单个IAC蛋白的机械传感功能并阐明其作用机制。
Cell and tissue stiffness have been known to contribute to both developmental and pathological signalling for some time, but the underlying mechanisms remain elusive. Integrins and their associated adhesion signalling complexes (IACs), which form a nexus between the cell cytoskeleton and the extracellular matrix, act as a key force sensing and transducing unit in cells. Accordingly, there has been much interest in obtaining a systems-level understanding of IAC composition. Proteomic approaches have revealed the complexity of IACs and identified a large number of components that are regulated by cytoskeletal force. Here we review the function of the
consensus adhesome, an assembly of core IAC proteins that emerged from a meta-analysis of multiple proteomic datasets, in the context of
mechanosensing. As IAC components have been linked to a variety of diseases involved with rigidity sensing, the field is now in a position to define the
mechanosensing function of individual IAC proteins and elucidate their mechanisms of action.