系统性硬化症（SSc）是一种异质性，慢性结缔组织病，以皮肤纤维化以及血管和内脏病变为特征。它可能涉及肺部，心,肾脏，胃肠道,和骨头。SSc的口面表现可引起功能性，美学，和社会困境，对患者产生重大的心理影响。近几十年来,脂肪移植在体积不足方面改善了美学效果，轮廓不对称，面部的皮肤弹性得益于其中包含的干细胞的再生作用。我们描述了5例接受脂肪移植治疗的SSc患者，用于纠正面部中部和下三分之一的嘴唇和口周区域的体积损失和面部弹性。所有患者在第1周和第2周接受定期术后检查。进行多项选择问卷以评估该程序的耐受性程度。通过使用MedCalc统计软件20.113版计算Cronbachα来评估问卷的可靠性。我们研究的目的是描述三种不同类型的脂肪移植，用于纠正体积损失并恢复面部中下三分之一的嘴唇和口周区域的面部弹性。
Systemic sclerosis (SSc) is a heterogeneous, chronic connective tissue disease, characterized by skin fibrosis as well as vascular and visceral lesions. It can involve the lungs, heart, kidneys, gastrointestinal tract, and bones. The orofacial manifestations of SSc can cause functional, aesthetic, and social distress, resulting in significant psychological implications for the patients. In recent decades, fat grafting improved the aesthetic outcomes in terms of volume deficiency, contour asymmetry, and skin elasticity of the face thanks to the regenerative action of the stem cells contained within it. We describe five cases of a patient with SSc treated with fat grafting used to correct volume loss and facial elasticity of the lips and perioral region on the middle and lower third of the face. All the patients received regular postoperative checks at weeks 1 and 2. A multiple choice questionnaire was administered to assess the degree of tolerability of the procedure. The reliability of the questionnaire was evaluated by calculating the Cronbach alpha using the MedCalc Statistical Software version 20.113. The aim of our study is to describe three different types of fat grafting used to correct volume loss and restore facial elasticity of the lips and perioral region on the middle and lower third of the face.
