背景:在老龄化人口中,认知障碍(CI)的发生率预计会增加。CI与牙齿脱落有关,影响咀嚼性能。咀嚼性能的下降可能会导致大脑的功能和形态变化。然而,CI是否与咀嚼性能相关,人口统计,和结构性大脑特征尚未被研究。
目的:一方面评估CI之间的关联,和咀嚼性能,人口因素,和结构性脑特征(即皮质体积和厚度)另一方面。
方法:总共,这项研究包括18名患有CI的老年人(平均±SD年龄=72.2±9.5岁)和68名患有CI的老年人(65.7±7.5岁)。使用可变色的口香糖定量咀嚼性能。磁共振成像(MRI)扫描用于绘制结构性脑特征图。为了研究我们的目标,采用反向选择进行多变量二元逻辑回归分析.
结果:右侧内嗅皮层的皮质体积与CI呈负相关(p<.01)。然而,人口因素,咀嚼性能,其他接受调查的脑结构性特征与CI无关.
结论:在老年人中,右侧内嗅皮质体积的减少与CI相关。
BACKGROUND: The occurrence of cognitive impairment (CI) is expected to increase within an ageing population. CI is associated with tooth loss, which influences masticatory performance. A decrease in masticatory performance may cause functional and morphological changes in the brain. However, whether CI is associated with masticatory performance, demographics, and structural brain signatures has not been studied yet.
OBJECTIVE: To assess the associations between CI on the one hand, and masticatory performance, demographic factors, and structural brain signatures (i.e. cortical volume and thickness) on the other hand.
METHODS: In total, 18 older adults with CI (mean ± SD age = 72.2 ± 9.5 years) and 68 older adults without CI (65.7 ± 7.5 years) were included in this
study. Masticatory performance was quantified using a colour-changeable chewing gum. A Magnetic Resonance Imaging (MRI) scan was used to map structural brain signatures. To
study our aim, a multivariate binary logistic regression analysis with backward selection was performed.
RESULTS: The cortical volume of the right entorhinal cortex was negatively associated with CI (p < .01). However, demographic factors, masticatory performance, and the other structural brain signatures under investigation were not associated with CI.
CONCLUSIONS: A decrease in the volume of the right entorhinal cortex is associated with CI in older people.