目的:原发性干燥综合征(pSS)的特征是外分泌腺体炎症;然而,之前的乳腺炎症相关疾病与新诊断的pSS之间的关联仍未被研究.方法:我们使用从台湾国家健康保险研究数据库(NHIRD)检索的2003-2013年数据进行本基于人群的研究。我们确定了2001-2013年期间新诊断的pSS女性患者,以及年龄匹配(1:20)和倾向评分匹配(1:2)的非SS个体(作为对照)。我们通过在控制潜在的混杂因素后,使用条件逻辑回归分析,确定具有95%置信区间(CI)的调整比值比(aOR),探索了pSS与乳腺炎和纤维囊性乳腺疾病病史之间的关联。结果:我们确定了9,665例pSS患者和193,300例年龄匹配的非SS对照。以及9,155例SS病例和18,310例倾向评分匹配的非SS对照。我们发现纤维囊性乳腺疾病(aOR,1.75;95%CI,1.63-1.88)与事件SS独立相关,而乳腺炎和分娩相关的乳腺感染与SS事件无关.我们还发现SS与先前报道的SS相关疾病之间存在正相关关系,包括心血管疾病,甲状腺疾病,胰腺炎,支气管扩张,传染病,骨质疏松,强直性脊柱炎.在倾向得分匹配的人群中,pSS与纤维囊性乳腺疾病之间的关系(aOR,1.74;95%CI,1.58-1.91)保持一致。结论:本基于人群的研究揭示了pSS与纤维囊性乳腺疾病病史之间的联系,这一发现强调了对乳腺炎症相关疾病患者进行pSS调查的必要性。
Objective: Primary Sjögren\'s syndrome (pSS) is characterized by exocrine glandular inflammation; however, the association between preceding mammary-gland-inflammation-related diseases and newly diagnosed pSS remains unexplored. Methods: We used the 2003-2013 data retrieved from Taiwan\'s National Health Insurance Research Database (NHIRD) to conduct the present population-based
study. We identified newly diagnosed pSS female patients during the 2001-2013 period, as well as age-matched (1:20) and propensity-score-matched (1:2) non-SS individuals (as controls). We explored the associations between pSS and a history of mastitis and fibrocystic breast disease by determining adjusted odds ratios (aORs) with 95% confidence intervals (CIs) using a conditional logistical regression analysis after controlling for potential confounders. Results: We identified 9,665 patients with pSS and 193,300 age-matched non-SS controls, as well as 9,155 SS cases and 18,310 propensity-score-matched non-SS controls. We found that fibrocystic breast disease (aOR, 1.75; 95% CI, 1.63-1.88) were independently associated with incident SS, whereas mastitis and childbirth-associated breast infections were not associated with incident SS. We also found positive associations between SS and previously reported SS-associated diseases, including cardiovascular diseases, thyroid diseases, pancreatitis, bronchiectasis, infectious diseases, osteoporosis, and ankylosing spondylitis. In the propensity-score-matched populations, the associations between pSS and fibrocystic breast disease (aOR, 1.74; 95% CI, 1.58-1.91) remained consistent. Conclusion: The present population-based
study revealed a previously unexplored association between pSS and history of fibrocystic breast disease, and the finding highlights the need to survey pSS in patients with mammary-gland-inflammation-associated diseases.