long-term care facility

长期护理机构
  • 文章类型: Journal Article
    背景:在台湾,患有和不患有痴呆症的居民大多生活在长期护理设施中。痴呆症居民的行为和精神症状通常会给共同生活的其他人带来挑战。这项研究探讨了没有痴呆症的居民与台湾长期护理机构中痴呆症患者共同生活的共生经历,以展示他们共同生活的经历。
    方法:这是一项具有现象学设计的横断面描述性研究。对台湾三家长期护理机构的30名无痴呆症居民进行了半结构化面对面访谈。Colaizzi的数据处理步骤用于分析。
    结果:对访谈记录的分析表明,与痴呆症患者一起生活的居民的经历是“共生”。“发现了三个核心主题:”共同生活的影响,“\”面对困难和应对,\"和\"的陪伴和互惠。“这项研究表明,没有痴呆症的居民在长期护理机构共同生活时,可能会受到痴呆症居民的行为和精神症状的影响。然而,他们之间也有积极和互利的互动。通过在日常生活中帮助痴呆症患者,没有痴呆症的居民感到快乐和有成就,他们的自我价值得到提高。此外,痴呆症患者有更多的社会参与和共同生活互动的机会。
    结论:这些结果可以指导没有特殊护理痴呆症病房的长期护理机构,以支持没有痴呆症的居民,减少对痴呆症居民行为和精神症状的干扰,促进互利。然而,这些发现值得进一步调查。
    BACKGROUND: In Taiwan, residents with and without dementia mostly co-live in long-term care facilities. The behavioral and psychiatric symptoms of dementia residents often pose challenges for others living together. This study explored the symbiotic experiences of residents without dementia co-living with those with dementia in long-term care facilities in Taiwan to present their experiences of living together.
    METHODS: This was a cross-sectional descriptive study with a phenomenological design. Semi-structured face-to-face interviews were conducted with 30 residents without dementia from three long-term care institutions in Taiwan. Colaizzi\'s data processing steps were used for analysis.
    RESULTS: The analysis of interview transcripts revealed that the experiences of residents who lived with those with dementia were that of a \"symbiosis.\" Three core themes were found: \"the impact of co-living,\" \"facing difficulties and coping,\" and \"companionship and reciprocity.\" This study showed that residents without dementia may be affected by the behavioral and psychiatric symptoms of residents with dementia when co-living in long-term care facilities. However, there are also positive and mutually beneficial interactions between them. By helping people with dementia in their daily lives, residents without dementia feel happy and accomplished and their self-worth is enhanced. Furthermore, residents with dementia have more opportunities for social engagement and co-living interactions.
    CONCLUSIONS: These results can guide long-term care facilities without special care dementia units to support residents without dementia, reduce the interference of the behavioral and psychiatric symptoms of residents with dementia, and promote mutual benefits. However, these findings warrant further investigation.
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  • 文章类型: Journal Article
    目的:本研究调查了富含大豆蛋白的膳食干预对长期护理机构中老年人肌肉健康的影响。
    方法:进行为期12周的单中心随机对照试验,对照组和开放标签设计。来自长期护理机构的84名老年人参加了这项研究。该设施的厨师使用营养师设计的富含大豆蛋白的食谱烹饪三餐。12周,干预组参与者每天吃三餐30克大豆蛋白(10克/餐),对照组参与者保持他们的习惯性饮食。
    结果:84名参与者(平均年龄,84.9±7.0岁;61.9%的女性)被随机分配到干预组(43名参与者)和对照组(41名参与者)。干预组的几个瘦体重指标显着增加,即软瘦质量(平均值,1.43千克;95%置信区间[CI]:0.20-1.65千克),骨骼肌质量(平均值,1.20千克;95%CI:0.43-1.96千克),阑尾骨骼肌质量(平均值,0.79千克;95%CI:0.07-1.52千克),和骨骼肌指数(平均值,0.37kg/m2;95%CI:0.05-0.68kg/m2(均P<0.05)。对照组未见上述变化(均P>0.05)。值得注意的是,对照组小腿围显着降低(平均值,-0.98cm;95%CI:-1.61至-0.36cm),但在干预组中保持不变。两组小腿围及6米步行表现差异有统计学意义(P<0.05)。
    结论:在长期护理机构中,12周的富含大豆蛋白的膳食干预改善了老年人的肌肉质量和6米步行表现。
    OBJECTIVE: This study investigated the effects of a soy protein-rich meal intervention on the muscle health of older adults in long-term care facilities.
    METHODS: A 12-week single-center randomized controlled trial with a control-group and open-label design was conducted. Eighty-four older adults from a long-term care facility participated in the study. The chefs at the facility cooked three meals using soy protein-rich recipes designed by dieticians. For 12 weeks, the intervention group participants consumed three meals with 30 g of soy protein (10 g/meal) per day, and the control group participants maintained their habitual diets.
    RESULTS: The 84 participants (mean age, 84.9 ± 7.0 years; 61.9% female) were randomly assigned to an intervention group (43 participants) and a control group (41 participants). The intervention group exhibited significant increases in several lean mass indicators, namely soft lean mass (mean, 1.43 kg; 95% confidence interval [CI]: 0.20-1.65 kg), skeletal muscle mass (mean, 1.20 kg; 95% CI: 0.43-1.96 kg), appendicular skeletal muscle mass (mean, 0.79 kg; 95% CI: 0.07-1.52 kg), and skeletal muscle index (mean, 0.37 kg/m2; 95% CI: 0.05-0.68 kg/m2) (all P < 0.05). These changes were not observed in the control group (all P > 0.05). Notably, calf circumference decreased significantly in the control group (mean, -0.98 cm; 95% CI: -1.61 to -0.36 cm) but was maintained in the intervention group. The differences in the calf circumference and 6-m walk performance of the two groups were significant (P < 0.05).
    CONCLUSIONS: The 12-week soy protein-rich meal intervention improved the muscle mass and 6-m walk performance of older adults in a long-term care facility.
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  • 文章类型: Journal Article
    长期护理设施在满足老年人群多样化的医疗保健需求方面面临越来越大的挑战,特别是关于药物管理。了解这些人群中的药物信息素养和行为势在必行。因此,这项定性研究旨在探讨老年长期护理住院医师的用药信息素养,并建立不同的用药概况.
    在这项研究中,我们对居住在长期护理机构的32名65岁或以上的参与者进行了深入的半结构化访谈.访谈旨在探索参与者对药物信息的理解,药物管理实践,以及与医疗保健提供者的经验。采用主题分析法对访谈数据进行分析,允许识别与老年居民服药行为相关的常见模式和主题。
    主题分析揭示了老年人长期护理居民中四个不同的用药行为特征:(1)主动健康自我管理者,(2)药物信息坚持者,(3)基于经验的药物使用者,和(4)非粘附性药物使用者。这些发现为长期护理机构中的各种药物管理方法提供了宝贵的见解,并强调了量身定制的干预措施以支持每个配置文件的特定需求的重要性。
    本研究强调了为老年人提供量身定制的药物教育和支持以优化药物管理的必要性。随着人口老龄化的扩大,解决长期护理机构中独特的药物挑战变得越来越重要。这项研究有助于不断努力加强老年人的医疗保健服务,追求更安全、更有效的服药行为。
    UNASSIGNED: Long-term care facilities are increasingly challenged with meeting the diverse healthcare needs of the elderly population, particularly concerning medication management. Understanding medication information literacy and behavior among this demographic is imperative. Therefore, this qualitative study aims to explore medication information literacy and develop distinct medication profiles among elderly long-term care residents.
    UNASSIGNED: In this study, we conducted in-depth semi-structured interviews with 32 participants aged 65 or older residing in a long-term care facility. The interviews were designed to explore participants\' understanding of medication information, medication management practices, and experiences with healthcare providers. Thematic analysis was employed to analyze the interview data, allowing for the identification of common patterns and themes related to medication-taking behavior among the elderly residents.
    UNASSIGNED: The thematic analysis revealed four distinct medication behavior profiles among the elderly long-term care residents: (1) Proactive Health Self-Managers, (2) Medication Information Adherents, (3) Experience-Based Medication Users, and (4) Nonadherent Medication Users. These findings provide valuable insights into the diverse approaches to medication management within long-term care facilities and underscore the importance of tailored interventions to support the specific needs of each profile.
    UNASSIGNED: This study highlights the necessity for tailored medication education and support to optimize medication management for the elderly. With the aging population expansion, addressing the unique medication challenges within long-term care facilities becomes increasingly critical. This research contributes to ongoing endeavors to enhance healthcare services for the elderly, striving for safer and more effective medication-taking behavior.
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  • 文章类型: Journal Article
    背景:老年养老院居民由于虚弱而跌倒的风险更大。运动可有效阻止虚弱和相关不良事件,包括瀑布。目标:我们的目的是评估为期12周的中等强度多成分运动计划对老年疗养院居民跌倒次数和身体机能的影响。此外,我们研究了跌倒次数与人口统计以及身体和认知基线数据之间的关联.方法:研究方案在clinicaltrials.gov上注册,标识符如下:NCT05835297。65岁及以上的老年人从疗养院招募,符合条件并同意的居民被随机分为两个平行组:干预组,进行了由力量组成的多组分锻炼计划,balance,和有氧训练(n=12),和对照组,接受常规护理(n=12)。结果包括跌倒,和力量的衡量标准,balance,和流动性。结果:我们对锻炼的依从性很高,并且没有记录到不良事件。我们观察到运动计划后,跌倒没有显着减少(p=0.34),而短物理性能电池则有显着改善(p=0.003)。跌倒与女性和身体或认知功能减弱有关。结论:应在疗养院定期实施多组分运动计划,以确保其有效性。未来有更大样本的研究,包括身体和认知障碍更严重的参与者,以及后续时期是必需的。
    Background: Older nursing home residents are at a greater risk of falling due to frailty. Exercise is effective at hampering frailty and related adverse events, including falls. Objectives: Our purpose was to evaluate the effect of a 12-week moderate-intensity multicomponent exercise programme on the number of falls and physical functioning among older nursing home residents. Also, we examined the association between the number of falls and demographics as well as physical and cognitive baseline data. Methods: The study protocol was registered on clinicaltrials.gov with the following identifier: NCT05835297. Older adults aged 65 years and over were recruited from a nursing home, and eligible and consenting residents were randomly allocated to two parallel groups: the intervention group, which performed a multicomponent exercise programme composed of strength, balance, and aerobic training (n = 12), and the control group, which received usual care (n = 12). Outcomes included falls, and measures of strength, balance, and mobility. Results: We had high adherence to exercise sessions, and no adverse events were recorded. We observed a non-significant reduction in falls (p = 0.34) and a significant improvement in Short Physical Performance Battery (p = 0.003) after the exercise programme. Falls were associated with being female and having diminished physical or cognitive function. Conclusions: Multicomponent exercise programmes should be implemented regularly in nursing homes for their effectiveness. Future studies with bigger samples, including participants with worse physical and cognitive impairments, as well as follow-up periods are required.
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  • 文章类型: Randomized Controlled Trial
    光影响体内褪黑激素的分泌并调节昼夜节律,在睡眠和情绪中起着重要作用。长期护理设施中房间的光照水平通常远低于调节身体昼夜节律所需的阈值,光线不足很容易导致养老院老年居民的睡眠和情绪障碍。因此,本研究的目的是探讨光疗对长期护理机构中2型糖尿病老年患者睡眠和昼夜节律的影响.
    这项研究是一项前瞻性研究,单盲,随机对照试验。参与者被随机分配到光疗(LT)组或对照组,并接受为期四周的干预。主要结果包括匹兹堡睡眠质量指数(PSQI)和睡眠监测手镯记录的客观睡眠参数。早晨-均匀性问卷(MEQ)。次要结果包括糖化血清蛋白(GSP)。在三个时间点收集数据:在基线(T0),立即治疗后(T1),4周随访(T2)。使用线性混合模型分析来分析数据。
    我们招募了45名长期护理住院医师。与对照组相比,在T1和T2时观察到PSQI评分显著降低.在T2时,LT组的客观睡眠参数的睡眠得分明显高于对照组。此外,与基线T0相比,LT组在T1和T2时MEQ评分显著降低,而对照组无显著差异。在T1和T2时,两组之间的糖化血清蛋白值没有显着差异。然而,与T0相比,LT组的糖化血清蛋白值在T2时降低,而对照组升高。
    光疗对长期护理2型糖尿病患者的主观睡眠质量和昼夜节律时间类型有积极影响,并可能对客观睡眠产生延迟影响。然而,本研究未检测到血糖水平的明显改变.
    Light influences the secretion of melatonin in the body and regulates circadian rhythms, which play an important role in sleep and mood. The light level of rooms in long-term care facilities is usually far below the threshold required to regulate the body\'s circadian rhythm, and insufficient light can easily lead to sleep and mood disturbances among older residents in nursing homes. Therefore, the objective of this study was to investigate the effects of light therapy on sleep and circadian rhythm in older adults with type 2 diabetes residing in long-term care facilities.
    This study was a prospective, single-blind, randomized controlled trial. Participants were randomly assigned to either the light therapy (LT) group or the control group and received the intervention for four weeks. Primary outcomes included the Pittsburgh Sleep Quality Index (PSQI) and objective sleep parameters recorded by a sleep monitoring bracelet, Morningness-Eveningness Questionnaire (MEQ). The secondary outcome included glycated serum protein (GSP). Data was collected at three time points: at baseline (T0), immediate post-treatment (T1), and 4-week follow-up (T2). A linear mixed model analysis was used to analyzed the data.
    We enrolled 45 long-term care residents. Compared with the control group, significant reductions in PSQI scores were observed at T1 and T2. At T2, the sleep score of objective sleep parameters was significantly higher in the LT group compared to the control group. Additionally, compared to the baseline T0, MEQ scores were significantly lower in the LT group at T1 and T2, with no significant difference in the control group. There was no significant difference between groups in glycated serum protein values at T1 and T2. However, compared to T0, glycated serum protein values decreased in the LT group while increased in the control group at T2.
    Light therapy had a positive effect on subjective sleep quality and circadian rhythm time type in long-term care residents with type 2 diabetes, and had a possible delayed effect on objective sleep. However, no discernible alterations in blood glucose levels were detected in this study.
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  • 文章类型: Journal Article
    目标:检查在2019年冠状病毒大流行期间,远离亲人的家庭护理人员的心理健康状况。
    方法:采用凯斯勒量表-10进行心理困扰定量测量的混合方法设计,以及用于定性分析的开放式问题。
    方法:参与者于2021年2月至9月从医疗机构招募。这项横断面研究包括197名家庭护理人员,他们正在为亲人使用正式的住宿护理服务。利用专题分析,对访问限制影响的开放式答复进行了编码。然后检查这些主题以确定跨护理人员特征的主题模式。
    结果:确定了关于访问限制的影响的13个主题。许多参与者报告的主要有害影响如下:“无法确认向年长亲戚提供的护理和生活方式援助的类型”和“由于无法面对面交谈而难以与年长亲戚沟通”。年龄更小,被雇用,睡眠不好,与受护理者的关系质量差以及因访问限制而受到有害影响与心理困扰相关.
    结论:我们的研究结果表明,要在护理过渡后保持积极的心理健康,重要的是,家庭照顾者要参与照顾他们所爱的人,并确保受照顾者的家庭和机构之间的信息共享。
    结论:这些发现表明,居住在设施外的居民和家庭照顾者都可能因分离而感到苦恼。因此,机构护理人员需要考虑如何调整机构程序或与家庭护理人员的沟通。
    从本次调查的参与者那里获得的评论有助于塑造研究设计,并有望为进一步发展优质的设施护理做出贡献。
    OBJECTIVE: To examine the mental health conditions of family caregivers residing away from their loved ones who experienced visitation restrictions during the coronavirus disease 2019 pandemic.
    METHODS: A mixed-methods design applying the Kessler Scale-10 for the quantitative measurement of psychological distress and an open-ended question for qualitative analysis.
    METHODS: The participants were recruited from care facilities between February and September 2021. This cross-sectional study included 197 family caregivers who were utilizing formal residential care services for their loved ones. Using thematic analyses, open-ended responses regarding the impact of visitation restrictions were coded. These themes were then examined to determine thematic patterns across caregiver characteristics.
    RESULTS: Thirteen themes were identified regarding the impact of visitation restrictions. Many participants reported primary harmful effects as follows: \'inability to confirm the type of care and lifestyle assistance provided to an older relative\' and \'difficulty communicating with an older relative because of the inability to converse face-to-face\'. Younger age, being employed, poor sleep, poor relationship quality with the care recipient and experiencing harmful effects from the visitation restrictions were associated with psychological distress.
    CONCLUSIONS: Our findings suggest that to maintain positive mental health after a care transition, it is important for family caregivers to take part in the care of their loved ones and ensure information sharing between the care recipient\'s family and institution.
    CONCLUSIONS: These findings suggest that both residents and family caregivers living outside facilities may feel distressed due to separation. Therefore, institutional care staff needs to consider how to adjust facility procedures or communication with family caregivers.
    UNASSIGNED: The comments obtained from the participants in this survey helped to shape the study design and are expected to contribute to the further development of quality facility care.
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  • 文章类型: Journal Article
    微量营养素摄入量低与疗养院居民的健康相关问题有关。由于他们的食物摄入量普遍较低,预计他们的微量营养素摄入量也会很低。根据3天的直接摄入量观察,测量了5个不同荷兰疗养院中189名居民(平均年龄85.0岁(SD:7.4))的营养摄入量。微量营养素摄入量,没有补给,是用荷兰食物成分表计算的,使用SPADE软件对习惯性摄入量进行建模。将摄入量与荷兰饮食参考值中所述的估计平均需求(EAR)或足够摄入量(AI)进行比较。低摄入被定义为>10%未达到EAR或当摄入的P50低于AI时。维生素A,硫胺素,核黄素,烟酸,B6,叶酸,B12,C,D,E,铜,铁,锌,钙,碘,镁,磷,钾,和硒进行了研究。我们的数据显示,大多数评估营养素的维生素和矿物质摄入量较低。只有硫胺素才有足够的摄入量,烟酸,维生素B12(仅限男性),碘(仅限男性),和磷。50%的人对核黄素的摄入量低于耳朵,vitB6,叶酸,和维生素D。对于以AI表示的参考值,p50维生素E的摄入量,钙,碘,镁,钾,硒低于AI。结论:在大多数养老院人口中,养老院居民的微量营养素摄入量太低。“食物优先”的方法可以增加饮食摄入量,但如果“食物优先”方法不成功,可以考虑补充。
    Low intake of micronutrients is associated with health-related problems in nursing home residents. As their food intake is generally low, it is expected that their micronutrient intake will be low as well. The nutrient intake of 189 residents (mean age 85.0 years (SD: 7.4)) in five different Dutch nursing homes was measured based on 3-day direct observations of intake. Micronutrient intake, without supplementation, was calculated using the Dutch food composition table, and SPADE software was used to model habitual intake. Intake was compared to the estimated average requirement (EAR) or adequate intake (AI) as described in the Dutch dietary reference values. A low intake was defined as >10% not meeting the EAR or when the P50 (median) intake was below the AI. Vitamin A, thiamin, riboflavin, niacin, B6, folate, B12, C, D, E, copper, iron, zinc, calcium, iodine, magnesium, phosphorus, potassium, and selenium were investigated. Our data showed that vitamin and mineral intake was low for most assessed nutrients. An AI was only seen for vitamin B12 (men only), iodine (men only), and phosphorus. A total of 50% of the population had an intake below the EAR for riboflavin, vit B6, folate, and vitamin D. For reference values expressed in AI, P50 intake of vitamin E, calcium, iodine, magnesium, potassium, and selenium was below the AI. To conclude: micronutrient intake in nursing home residents is far too low in most of the nursing home population. A \"food-first\" approach could increase dietary intake, but supplements could be considered if the \"food-first\" approach is not successful.
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  • 文章类型: Journal Article
    目标:初级卫生保健(PHC)支持COVID-19主治患者的长期护理设施(LTCF)。这项研究的目的是描述在大流行早期阶段PHC在欧洲LTCF中的作用。
    方法:来自30个欧洲国家的回顾性描述性研究,使用2020年9月的临时半结构化问卷收集的数据。相关变量是SARS-CoV-2测试,接触追踪,后续行动,额外的测试,和病人护理。
    结果:在COVID-19大流行期间,30个欧洲国家中有26个国家参与了LTCF的PHC。PHC参与了22个国家的初始医疗保健,while,15年,PHC与其他机构一起负责SARS-CoV-2测试。对隔离个人的监督主要由LTCF工作人员进行,但体格检查或症状随访主要由PHC进行。
    结论:PHC与LTCF工作人员协调,参与了LTCF中的COVID-19大流行援助,公共卫生官员,和医院。
    OBJECTIVE: Primary health care (PHC) supported long-term care facilities (LTCFs) in attending COVID-19 patients. The aim of this study is to describe the role of PHC in LTCFs in Europe during the early phase of the pandemic.
    METHODS: Retrospective descriptive study from 30 European countries using data from September 2020 collected with an ad hoc semi-structured questionnaire. Related variables are SARS-CoV-2 testing, contact tracing, follow-up, additional testing, and patient care.
    RESULTS: Twenty-six out of the 30 European countries had PHC involvement in LTCFs during the COVID-19 pandemic. PHC participated in initial medical care in 22 countries, while, in 15, PHC was responsible for SARS-CoV-2 test along with other institutions. Supervision of individuals in isolation was carried out mostly by LTCF staff, but physical examination or symptom\'s follow-up was performed mainly by PHC.
    CONCLUSIONS: PHC has participated in COVID-19 pandemic assistance in LTCFs in coordination with LTCF staff, public health officers, and hospitals.
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  • 文章类型: Journal Article
    背景:2019年冠状病毒病(COVID-19)仍然是对长期护理机构(LTCF)居民等弱势群体的威胁,他们往往年纪较大,严重虚弱,并有多种合并症。尽管已经研究了COVID-19mRNA疫苗免疫原性之间的关联,耐用性,以及对加强疫苗接种和实际年龄的反应,关于临床因素的关联数据,如表现状况,营养状况,除了实际年龄以外的潜在合并症是有限的。这里,我们评估了LTCF居民血清中针对野生型病毒和Delta和Omicron变体的抗穗IgG水平和中和活性,门诊病人,在初次疫苗接种前;在初次疫苗接种后8、12和24周;以及加强疫苗接种后约3个月。这项为期48周的前瞻性纵向研究已在UMIN临床试验注册中心(试验编号:UMIN000043558)中注册。
    结果:在114名未感染的参与者中(64名LTCF居民,29名门诊病人,和21名医护人员),在初次疫苗接种后24周内,LTCF居民的抗尖峰IgG水平和对野生型病毒和Delta变体的中和活性明显低于门诊患者和医护人员。在LTCF居民中,与门诊患者相比,加强疫苗接种引起对野生型病毒和Delta变体的中和活性,而针对Omicron变体的中和活性与门诊患者和医护人员相当。多元回归分析显示,在初次接种疫苗后,年龄与抗刺突IgG水平和针对野生型病毒和Delta变体的中和活性呈负相关。然而,多变量回归分析显示,与年龄相比,不良表现状态和低蛋白血症与较低的体液免疫反应更密切相关。合并症的数量,或初次接种疫苗后的性行为。加强疫苗接种抵消了不良表现状态和低蛋白血症对体液免疫反应的负面影响。
    结论:LTCF居民在初次接种疫苗后表现出次优的免疫应答。尽管年龄较大与较低的体液免疫反应显着相关,在初次接种疫苗后,不良表现和低蛋白血症与较低的体液免疫反应密切相关.因此,加强疫苗接种对老年人有益,尤其是那些表现不佳和低蛋白血症的人。
    BACKGROUND: Coronavirus disease 2019 (COVID-19) remains a threat to vulnerable populations such as long-term care facility (LTCF) residents, who are often older, severely frail, and have multiple comorbidities. Although associations have been investigated between COVID-19 mRNA vaccine immunogenicity, durability, and response to booster vaccination and chronological age, data on the association of clinical factors such as performance status, nutritional status, and underlying comorbidities other than chronological age are limited. Here, we evaluated the anti-spike IgG level and neutralizing activity against the wild-type virus and Delta and Omicron variants in the sera of LTCF residents, outpatients, and healthcare workers before the primary vaccination; at 8, 12, and 24 weeks after the primary vaccination; and approximately 3 months after the booster vaccination. This 48-week prospective longitudinal study was registered in the UMIN Clinical Trials Registry (Trial ID: UMIN000043558).
    RESULTS: Of 114 infection-naïve participants (64 LTCF residents, 29 outpatients, and 21 healthcare workers), LTCF residents had substantially lower anti-spike IgG levels and neutralizing activity against the wild-type virus and Delta variant than outpatients and healthcare workers over 24 weeks after the primary vaccination. In LTCF residents, booster vaccination elicited neutralizing activity against the wild-type virus and Delta variant comparable to that in outpatients, whereas neutralizing activity against the Omicron variant was comparable to that in outpatients and healthcare workers. Multiple regression analyses showed that age was negatively correlated with anti-spike IgG levels and neutralizing activity against the wild-type virus and Delta variant after the primary vaccination. However, multivariate regression analysis revealed that poor performance status and hypoalbuminemia were more strongly associated with a lower humoral immune response than age, number of comorbidities, or sex after primary vaccination. Booster vaccination counteracted the negative effects of poor performance status and hypoalbuminemia on the humoral immune response.
    CONCLUSIONS: LTCF residents exhibited suboptimal immune responses following primary vaccination. Although older age is significantly associated with a lower humoral immune response, poor performance status and hypoalbuminemia are more strongly associated with a lower humoral immune response after primary vaccination. Thus, booster vaccination is beneficial for older adults, especially those with a poor performance status and hypoalbuminemia.
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  • 文章类型: Journal Article
    这项为期1年的多中心前瞻性队列研究旨在确定日本长期护理保险机构中老年人可观察到的进食和吞咽功能因素与结果(死亡/住院或生存)之间的关系。因素的基线评估,如语言,流口水,口臭,唾液分泌过多,舌头运动,口周肌肉功能,咳嗽,吞咽后的呼吸,冲洗,和口腔残留物,其中,进行了。0分被认为是积极的,1分或2分被认为是阴性.患者年龄,性别,身体质量指数,Barthel指数,记录临床痴呆评分。记录1年以上的死亡/住院或生存率,根据各自的结局(死亡/住院组或生存组)和基线特征将患者分组.共包括来自32个设施的986名居民,死亡/住院组216例,存活组770例。语言,流涎,口臭,口周肌,咳嗽,吞咽后的呼吸,冲洗,和口服残留与结局显着相关(p<0.05)。因此,照护者进行这些简单评估的常规表现可能有助于早期发现和治疗以预防死亡,肺炎,抽吸,老年人营养不良。
    This 1-year multicenter prospective cohort study aimed to determine the association between observable eating and swallowing function factors and outcomes (death/hospitalization or survival) among elderly persons in long-term care insurance facilities in Japan. Baseline assessments of factors, such as language, drooling, halitosis, hypersalivation, tongue movement, perioral muscle function, coughing, respiration after swallowing, rinsing, and oral residue, among others, were conducted. A score of 0 was considered positive, and a score of 1 or 2 was considered negative. Patient age, sex, body mass index, Barthel index, and Clinical Dementia Rating were recorded. The death/hospitalization or survival rates over 1 year were recorded, and patients were allocated into groups depending on the respective outcome (death/hospitalization group or survival group) and baseline characteristics. A total of 986 residents from 32 facilities were included, with 216 in the death/hospitalization group and 770 in the survival group. Language, salivation, halitosis, perioral muscle, coughing, respiration after swallowing, rinsing, and oral residue were significantly associated with the outcomes (p < 0.05). Therefore, routine performance of these simple assessments by caregivers may allow early detection and treatment to prevent death, pneumonia, aspiration, and malnutrition in elderly persons.
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