巨大基底细胞癌(GBCC)是基底细胞癌(BCC)的一种罕见变体,更大(>5cm)且更具侵袭性。虽然BCC通常是手术切除的,局部肿瘤,GBCC病例占BCC恶性肿瘤和死亡率的很大一部分。GBCC的增长被认为是多因素的,由于BCC的成功治疗,可用数据有限。我们介绍了一例在92岁的男性尸体中进行常规尸检时发现的GBCC病例。肿瘤好发于耳周软组织浸润,尽管表现出转移的高风险特征。显微镜分析显示了浸润性生长模式和神经嗜性。在大体解剖上可以观察到神经周围扩散,表明预后较差,但没有淋巴或血行扩散的证据.这很可能是由于BCC的基质依赖性。原发肿瘤局部浸润可能损害头颈部功能,但没有继发性肿瘤的证据.没有组织病理学发现表明肿瘤的侵袭性生长或转移性转化。因此,虽然由于尸体的匿名性,无法得出关于持续时间的结论,生长持续时间可能是死亡率的重要因素.
A giant basal cell carcinoma (GBCC) is a rare variant of basal cell carcinoma (BCC) that is larger (>5 cm) and more aggressive. While BCC is usually surgically excised as a small, local tumor, cases of GBCC represent a considerable portion of BCC malignancies and mortality. The growth of GBCC is hypothesized to be multifactorial, and due to the successful treatment of BCC, available data is limited. We present a
case of GBCC found during routine post-mortem dissection in a 92-year-old male cadaver. The neoplasm showed predilection to periauricular soft tissue invasion, despite demonstrating high-risk characteristics for metastasis. Microscopic analysis demonstrated an infiltrative growth pattern and neurotropism. Perineural spread could be observed on gross dissection, indicating a worse prognosis, but there was no evidence of lymphatic or hematogenous spread. This is most likely due to the stromal dependence of BCC. Local invasion of the primary tumor likely compromised head and neck function, but there was no secondary tumor evidence. There were no histopathological findings that indicate an aggressive growth or metastatic transformation of the tumor. Therefore, while a conclusion about duration cannot be made due to the anonymity of the cadaver, duration of growth likely was a significant factor in mortality.