■最近的研究发现,甲状腺功能可能与代谢功能障碍相关的脂肪肝(MAFLD)患者晚期肝纤维化的发生和发展有关。然而,大多数此类研究都是横断面研究。这项回顾性队列研究旨在探讨低正常甲状腺功能对MAFLD患者在5年内晚期肝纤维化的影响。
■这项回顾性队列研究纳入了中山大学附属第三医院就诊的825例MAFLD门诊患者和住院患者(广州,中国)2011年1月至2018年12月。根据血浆甲状腺激素和促甲状腺激素水平,这些患者分为两组,即正常甲状腺功能低组和严格正常甲状腺功能组。纤维化-4评分用于评估晚期肝纤维化。进行卡方检验以比较各组之间晚期纤维化的发生。
■在825例MAFLD患者中,117和708被定义为具有低正常甲状腺功能和严格正常甲状腺功能,分别。在5年期间,767例患者(93.0%)的随访数据可用。8例(7.5%)甲状腺功能正常的MAFLD患者和26例(3.9%)甲状腺功能正常的MAFLD患者出现了晚期肝纤维化,累积发生率没有显着差异(P=0.163)。分层分析显示,甲状腺功能低于正常的瘦肉MAFLD患者(体重指数≤23kg/m2)发生晚期肝纤维化的风险高于甲状腺功能严格正常的瘦肉MAFLD患者(P<0.05)。
■低正常甲状腺功能与瘦肉MAFLD患者的晚期肝纤维化相关。
UNASSIGNED: Recent studies have found that thyroid function may be associated with the occurrence and development of advanced liver fibrosis in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). However, the majority of such research has consisted of cross-sectional studies. This retrospective cohort
study aimed to investigate the effect of low-normal thyroid function on advanced liver fibrosis in MAFLD patients over a 5-year period.
UNASSIGNED: This retrospective cohort
study enrolled 825 outpatients and inpatients with MAFLD who attended the Third Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) between January 2011 and December 2018. Based on plasma thyroid hormone and thyroid-stimulating hormone levels, these patients were divided into two groups, namely a low-normal thyroid function group and a strict-normal thyroid function group. The fibrosis-4 score was used to assess advanced liver fibrosis. A chi-square test was conducted to compare the occurrence of advanced fibrosis between the groups.
UNASSIGNED: Among the 825 MAFLD patients, 117 and 708 were defined as having low-normal thyroid function and strict-normal thyroid function, respectively. Follow-up data were available for 767 patients (93.0%) during a 5-year period. Eight (7.5%) MAFLD patients with low-normal thyroid function and 26 (3.9%) with strict-normal thyroid function developed advanced liver fibrosis and the cumulative incidence was not significantly different (P = 0.163). Stratification analysis showed that the lean MAFLD patients (body mass index ≤ 23 kg/m2) with low-normal thyroid function had a higher risk of advanced liver fibrosis than the lean MAFLD patients with strict-normal thyroid function (P < 0.05).
UNASSIGNED: Low-normal thyroid function is associated with advanced liver fibrosis among lean MAFLD patients.