糖尿病是常见的,慢性,和复杂的疾病,导致几个残疾和严重的并发症。某些营养素可以有效地管理糖尿病。在本研究中,我们的目的是研究膳食硝酸盐的影响,亚硝酸盐,膳食总抗氧化能力(DTAC),和一氧化氮(NO)指数对糖尿病患者某些心脏代谢参数的影响。这项横断面研究是对100名2型糖尿病患者进行的。一个经过验证的,半定量,收集食物频率问卷来评估膳食摄入量。人体测量参数,血压,和生化参数,包括血糖指数,血脂谱,高敏C反应蛋白(hs-CRP),使用标准方法测量血清NO。在我们的研究中,硝酸盐和亚硝酸盐的摄入量较高主要归因于饮用水,蔬菜,谷物(硝酸盐),乳制品,和豆类(亚硝酸盐),而不是更高的肉类摄入量。调整总能量后,MET,BMI,和年龄,较高的硝酸盐摄入量与较低的HbA1C(p=0.001)和hs-CRP(p=0.0.23)有关,和更高的HDL-C(p<0.001)和血清NO(p=0.008)。此外,较高的亚硝酸盐摄入量与较低的DBP相关(p=0.017),HbA1C(p=0.040),FPG(p=0.011),和更高的血清NO值(p=0.001)。较高的DTAC和NO指数也与较高的DBP(分别为p<0.001和p=0.004)和较低的hs-CRP(分别为p=0.004和p=0.009)有关。膳食硝酸盐和亚硝酸盐的高摄入量,在高DTAC的背景下,与糖尿病患者某些心脏代谢参数的改善显着相关。
亚硝酸盐的较高摄入量与改善血糖指数有关。硝酸盐摄入量较高与HDL-C升高和hs-CRP降低有关。硝酸盐和亚硝酸盐的摄入量较高,DTAC指数很高,与心脏代谢参数降低有关。
Diabetes is a common, chronic, and complex disorder that leads to several disabilities and serious complications. Certain nutrients can be effective in the management of diabetes mellitus. In the present
study, we aimed to investigate the effects of dietary nitrate, nitrite, dietary total antioxidant capacity (DTAC), and nitric oxide (NO) index on some cardiometabolic parameters in patients with diabetes. This cross-sectional
study was conducted on 100 participants with type 2 diabetes. A validated, semi-quantitative, food frequency questionnaire was collected to evaluate dietary intakes. Anthropometric parameters, blood pressure, and biochemical parameters, including glycemic indices, lipid profile, high-sensitive C-reactive protein (hs-CRP), and serum NO were measured using standard methods. Higher intakes of nitrate and nitrite in our
study were primarily attributed to drinking water, vegetables, grains (for nitrate), dairy products, and legumes (for nitrite) rather than higher meat intakes. After adjustment for total energy, MET, BMI, and age, higher intake of nitrate was related to lower HbA1C (p = 0.001) and hs-CRP (p = 0.0.23), and greater HDL-C (p < 0.001) and serum NO (p = 0.008). Moreover, a greater nitrite intake was associated with lower DBP (p = 0.017), HbA1C (p = 0.040), FPG (p = 0.011), and higher serum NO values (p = 0.001). Higher amounts of DTAC and NO index were also related to greater DBP (p < 0.001, and p = 0.004, respectively) and lower hs-CRP (p = 0.004, and p = 0.009, respectively). High intakes of dietary nitrate and nitrite, in the context of high DTAC, are significantly associated with the improvement of some cardiometabolic parameters in patients with diabetes.
A higher intake of nitrite is related to improving glycemic indices.A higher intake of nitrate is related to increasing HDL-C and decreasing hs-CRP.A higher intake of nitrate and nitrite, with a high DTAC index, is related to reduced cardiometabolic parameters.