左心房的增大和功能障碍与不良后果有关。在估计LA体积和射血分数方面,3D超声心动图比2D超声心动图更准确。然而,3DE在LA分析中的应用由于缺乏确定的参考值而受到限制.我们进行了系统评价和荟萃分析,以提供以体表面积为索引的LA最大和最小体积的参考范围(LAVimax和LAVimin,分别),通过3DE评估健康成人的LA-EF。从开始到2021年9月15日进行数据搜索,使用以下医学主题标题术语:左心房/心房,三维/3D超声心动图。研究方案在PROSPERO数据库(CRD42021252428)中注册。15项研究包括4,226名健康成年人(51%的男性),并报告了LAVimax的3DE值,选择LAVimin和LA-EF。LAVimax,LAVimin和LA-EF平均值和参考值等于25.18ml/m2(95%CI23.10,27.26),11.10ml/m2(10.01,12.18)和55.94%(51.92,59.96),分别。没有发现有影响的研究。还估计了每个年龄组和性别的汇总估计。通过荟萃回归分析,我们根据参与者的年龄确定了LA体积和LA-EF的变异性,3D多拍采集时的种族和心动周期数。在对374名受试者进行的个体患者数据分析中,显示了对LA-EF的软件效果.本系统综述和荟萃分析提供了LAVimax的参考值,通过3DE评估健康成人的LAVimin和LA-EF,鼓励在日常实践中对LA评估进行3DE评估。
Increased sizes and dysfunction of the left atrium have been related to adverse outcomes. 3D-echocardiography is more accurate than 2D-echocardiography in estimating LA volumes and ejection fraction. However, the use of 3DE for LA analysis is limited by the absence of established reference values. We performed a systematic
review and meta-analysis to provide reference ranges of LA maximum and minimum volumes indexed for body surface area (LAVi max and LAVi min, respectively), and LA-EF assessed by 3DE in healthy adults. Data search was conducted from inception through September 15, 2021, using the following Medical Subject Heading terms: left atrial/atrium, three-dimensional/3D echocardiography. The study protocol was registered in the PROSPERO database (CRD42021252428). 15 studies including 4,226 healthy adults (51% males) and reporting 3DE values of LAVi max, LAVi min and LA-EF were selected. LAVi max, LAVi min and LA-EF mean and reference values were equal to 25.18 ml/m2 (95% CI 23.10, 27.26), 11.10 ml/m2 (10.01, 12.18) and 55.94% (51.92, 59.96), respectively. No influential studies were identified. Pooled estimates per age group- and sex were also estimated. By meta-regression analyses, we identified variability in LA volumes and LA-EF depending on participants\' age, ethnicity and number of heart cycles at 3D multi-beat acquisition. At individual patient data analysis conducted on 374 subjects, a software effect on LA-EF was shown. This systematic
review and meta-analysis provides reference values of LAVi max, LAVi min and LA-EF assessed by 3DE in healthy adults, encouraging 3DE evaluation of the LA evaluation in daily practice.