背景:这项研究的目的是调查临床特征,诊断,和治疗甲状腺炎性肌纤维母细胞瘤肿瘤(IMT)。
方法:本研究共纳入2010年至2020年的17例IMT患者。临床特征,成像特征,治疗,在这项回顾性研究中分析了预后。
结果:病例系列包括5名男性和12名女性,平均年龄49.6±15.36岁。患者分为两组:IMT无进一步病理改变和甲状腺进一步病理改变(例如,结节性甲状腺肿或自身免疫性甲状腺疾病)。两组之间在肿瘤大小和甲状腺外延伸方面没有显着差异。2例术前进行细针穿刺活检,术中进行快速冷冻病理检查7例。5例仅有一种病理类型的超声图像,IMT,呈现恶性肿瘤的高风险和中等风险。在其他11例甲状腺进一步病理改变中,图像的恶性或良性特征的风险可能非常低。只有2例表现出恶性肿瘤的超声特征。5/17例患者除甲状腺手术外还接受了预防性颈淋巴结清扫术。术后病理证实无淋巴结阳性。甲状腺超声,肺部计算机断层扫描扫描,腹部超声,甲状腺功能检查为常规随访检查.在26-141个月的随访期间,2例丢失,其余15例患者无复发或转移,均认为治愈。
结论:甲状腺IMT是一种罕见疾病,预后良好,手术切除是首选治疗方法。
BACKGROUND: The objective of this
study was to investigate the clinical characteristics, diagnosis, and treatment of inflammatory myofibroblastoma tumor (IMT) in the thyroid gland.
METHODS: A total of 17 patients with IMT by pathology from 2010 to 2020 were included in this
study. Clinical features, imaging features, treatment, and prognosis were analyzed in this retrospective
study.
RESULTS: The case series comprised 5 males and 12 females, with an average age of 49.6 ± 15.36 years. The patients were divided into two cohorts: with IMT without further pathological changes and with further pathological changes of the thyroid gland (e.g., nodular goiter or autoimmune thyroid disease). No significant differences were detected in tumor size and extrathyroid extension between the two groups. Fine needle aspiration biopsy examination before the operation was performed in 2 cases, and rapid freezing pathology examination during the operation was performed in 7 cases. Ultrasound images of 5 cases with only one type of pathology, IMT, presented a high and intermediate risk of malignancy. In the other 11 cases with further pathological changes of the thyroid gland, the image could be very low risk of malignancy or benign feature. Only 2 cases showed a high risk of malignancy ultrasound features. 5/17 patients underwent preventive cervical lymph node dissection additional to thyroid surgery. None of the lymph nodes were confirmed positive by postoperative pathology. Thyroid ultrasound, computed tomography scan of the lungs, abdomen ultrasound, and thyroid function tests were routine follow-up tests. During the follow-up period of 26-141 months, 2 cases were lost, and remaining 15 cases had no recurrence or metastasis and were considered cured.
CONCLUSIONS: IMT in the thyroid gland is a rare disease with a good prognosis and surgical resection is the preferred treatment.