青少年脑认知发育(ABCD)研究是美国最大的神经发育和儿童健康的单队列前瞻性纵向研究。在22个地点招募了n=11,880名9-10岁的儿童(及其父母/监护人),并每年进行至少10年的面对面访问。这项研究在几个关键的社会人口统计学变量上接近了美国人口,包括性,种族,种族,家庭收入,和父母教育。收集的数据包括健康评估,心理健康,物质使用,文化、环境和神经认知,以及地理编码曝光,结构和功能磁共振成像(MRI),和全基因组基因分型。这里,我们描述了ABCD研究的目标和设计,以及围绕使用其数据估计有意义的关联的问题,包括人口推断,假设检验,功率和精度,控制协变量,协会的解释,并推荐可重复研究的最佳实践,分析程序和结果报告。
The Adolescent Brain Cognitive Development (ABCD)
Study is the largest single-cohort prospective longitudinal
study of neurodevelopment and children\'s health in the United States. A cohort of n = 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The
study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD
Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.