UNASSIGNED:目的比较开放射频消融术联合脾切除和心包断流术与肝移植治疗肝癌合并门静脉高压和脾功能亢进患者的短期和长期治疗效果。
未经评估:在研究期间,连续的肝癌门脉高压和脾功能亢进患者的治疗结果,将脾切除术和心包血管离断术(研究组)与接受肝移植的HCC患者的病例匹配对照组的治疗结果进行比较.
未经评估:研究组由32名患者组成,对照组包括从155例肿瘤大小匹配的患者中选择的32例患者,年龄,性别,MELD疼痛,肿瘤位置,TNM分类,脾肿大程度和Child-Pugh分期。两组的术前实验室检查和肿瘤特征的基线数据具有可比性。研究组和对照组的平均随访时间分别为43.2±5.3个月和44.9±5.8个月,分别。尽管对照组的无病生存率优于研究组(P<0.001)。两组患者累积总生存时间和门静脉血栓形成发生率差异无统计学意义(P=0.670,0.083).与对照组相比,研究组术中出血量明显减少,术后胸腔积液和肺炎的发生率较低(均P<0.05)。
未经评估:开放式射频消融,对于肝供体短缺的部分精心挑选的患者,脾切除术和心包血管离断术治疗小肝癌合并门脉高压和脾功能亢进可作为替代疗法.
UNASSIGNED: To compare the short- and long-term treatment outcomes of open radiofrequency ablation combined with splenectomy and pericardial devascularization versus liver transplantation for hepatocellular carcinoma patients with portal hypertension and
hypersplenism.
UNASSIGNED: During the study period, the treatment outcomes of consecutive HCC patients with portal hypertension and
hypersplenism who underwent open radiofrequency ablation, splenectomy and pericardial devascularization (the study group) were compared with the treatment outcomes of a
case-matched control group of HCC patients who underwent liver transplantation.
UNASSIGNED: The study group consisted of 32 patients, and the control group comprised 32 patients selected from 155 patients who were
case-matched by tumor size, age, gender, MELD sore, tumor location, TNM classification, degree of splenomegaly and Child-Pugh staging. Baseline data on preoperative laboratory tests and tumor characteristics were comparable between the two groups. The mean follow-up was 43.2 ± 5.3 months and 44.9 ± 5.8 months for the study and control groups, respectively. Although the disease-free survival rates of the control group were better than those of the study group (P < 0.001), there was no significant difference in the cumulative overall survival time or the incidence of portal vein thrombosis between the two groups (P = 0.670, 0.083). Compared with the control group, the study group had significantly less intraoperative blood loss, and lower incidences of postoperative pleural effusion and pneumonia (all P < 0.05).
UNASSIGNED: Open radiofrequency ablation, splenectomy and pericardial devascularization for small HCCs with portal hypertension and
hypersplenism can be an alternative therapy for a subset of carefully selected patients under the shortage of liver donors.