鉴于有关于弱视血管密度的有争议的发现,我们使用光学相干断层扫描血管造影量化视网膜微循环,并在远视性屈光不正性弱视眼和年龄匹配的对照眼之间进行比较.本病例对照研究于2021年3月至2022年3月在南昌大学附属眼科医院进行,南昌,中国。两组共72只眼。中心凹无血管区,圆度和周长,黄斑浅表视网膜毛细血管丛的灌注密度和血管密度,黄斑厚度,黄斑体积,乳头周围视网膜神经纤维层厚度,比较了远视屈光不正性弱视眼和年龄匹配的对照眼的神经节细胞内网状层厚度。此外,最佳矫正视力,最大角膜曲率,最小角膜曲率,并测量前房深度。在远视屈光不正性弱视眼和控制眼,中央血管密度为7.51±2.13和9.91±2.71mm-1,内部17.20±1.38和18.25±1.37mm-1,全区域17.90±0.88和18.43±0.97mm-1,分别。中央的灌注密度分别为0.17±0.06和0.23±0.07,内部为0.41±0.05和0.44±0.03,全区域为0.44±0.03和0.46±0.02,分别。远视屈光不正性弱视和对照眼的中心黄斑厚度分别为240.04±20.11和235.08±24.41µm,分别。两组之间的中央凹无血管区周长和圆形度(P<.043和P=.001)显着差异。远视屈光不正性弱视眼睛的血管和灌注密度明显较低,可能是远视性弱视的主要病理生理机制之一,为弱视的诊断和治疗提供了新的方向。
Given that there are controversial findings regarding vessel density in amblyopia, we quantified retinal microcirculation using optical coherence tomography angiography and compared it between hyperopic ametropic amblyopia eyes and age-matched control eyes. This
case-control study was conducted from March 2021 to March 2022 at the Affiliated Eye Hospital of Nanchang University, Nanchang, China. Both groups included 72 eyes. Foveal avascular zone area, circularity and perimeter, perfusion density and vessel density of macular superficial retinal capillary plexus, macular thickness, macular volume, peripapillary retinal nerve fiber layer thickness, and ganglion cell-inner plexiform layer thickness were compared between hyperopia ametropic amblyopia eyes and age-matched control eyes. Additionally, best-corrected visual acuity, maximum corneal curvature, minimum corneal curvature, and anterior chamber depth were measured. In the
hyperopia ametropic amblyopia eyes and control eyes, vessel density was 7.51 ± 2.13 and 9.91 ± 2.71 mm-1 in the central, 17.20 ± 1.38 and 18.25 ± 1.37 mm-1 in the inner, and 17.90 ± 0.88 and 18.43 ± 0.97 mm-1 in the full regions, respectively. The perfusion densities were 0.17 ± 0.06 and 0.23 ± 0.07 in the central, 0.41 ± 0.05 and 0.44 ± 0.03 in the inner, and 0.44 ± 0.03 and 0.46 ± 0.02 in the full regions, respectively. The central macular thicknesses of
hyperopia ametropic amblyopia and control eyes were 240.04 ± 20.11 and 235.08 ± 24.41 µm, respectively. Foveal avascular zone perimeter and circularity (P < .043 and P = .001) significantly differed between the 2 groups.
Hyperopia ametropic amblyopia eyes showed lower appreciably in vessel and perfusion densities, which could be one of the major pathophysiological mechanisms of
hyperopia ametropic amblyopia and provide a new direction for the diagnosis and treatment of amblyopia.