背景:腰椎融合治疗腰椎退行性疾病经常使用,尽管目前的研究提出了不确定的证据。本研究旨在系统回顾和荟萃分析腰椎退行性疾病患者的疼痛和残疾的自然过程,如椎管狭窄,脊椎滑脱,椎间盘突出,或椎间盘源性腰痛,以改善腰椎融合管理。
方法:将在2015年9月30日之前使用MEDLINE进行电子数据库搜索,EMBASE,CINAHL,和ZETOC数据库。此外,在媒体上搜索文章并提前出版,英国国家报告文献参考书目,和OpenGrey将进行。使用疼痛和残疾结果测量的前瞻性队列研究将有资格纳入。两名审阅者将筛选标题,摘要,和全文独立使用预定的纳入和排除标准。纳入研究的偏倚风险将使用改良版本的“预后研究质量”工具进行评估。如果结果数据的荟萃分析被认为是适当的,将计算方差加权合并均值。
结论:本系统评价和荟萃分析的结果可能会提高对腰椎融合术后恢复的认识,并改善腰椎融合术的管理。
背景:PROSPEROCRD42015026922.
BACKGROUND: Lumbar spinal fusion for degenerative disorders of the lumbar spine is frequently used, despite current research presenting inconclusive evidence. This study aims to systematically
review and meta-analyse the natural course of pain and disability in patients with degenerative disorders of the lumbar spine such as spinal stenosis, spondylolisthesis, disc herniation, or discogenic low back pain to improve lumbar spinal fusion management.
METHODS: An electronic database search will be conducted up to 30 September 2015 using MEDLINE, EMBASE, CINAHL, and ZETOC database. In addition, a search for articles in press and published ahead of print, British National Bibliography for Report Literature, and OpenGrey will be conducted. Prospective cohort studies using outcome measures of pain and disability will be eligible for inclusion. Two reviewers will screen titles, abstracts, and full-text independently using predetermined inclusion and exclusion criteria. The risk of bias of included studies will be assessed with the modified version of the Quality in Prognostic Studies tool. If meta-analysis of outcome data is deemed appropriate, variance-weighted pooled means will be calculated.
CONCLUSIONS: The results of this systematic
review and meta-analysis may improve understanding of recovery after lumbar spinal fusion and improve lumbar spinal fusion management.
BACKGROUND: PROSPERO CRD42015026922.