背景没有可靠的证据表明血型与子宫内膜异位症的风险有关,沙特阿拉伯没有研究检查这种关联。因此,主要目的是确定沙特阿拉伯队列中ABO和Rh血型分布与子宫内膜异位症发病率之间是否存在关联,并评估人群中与子宫内膜异位症相关的潜在危险因素.方法这项病例对照研究包括被诊断为子宫内膜异位症的妇女(n=44),这些妇女被送到阿卜杜勒阿齐兹国王大学医院妇产科诊所,吉达,沙特阿拉伯,2010年至2021年。来自阿卜杜勒阿齐兹国王大学医院的献血者数据库的妇女被纳入对照组(n=184)。总样本量为228。人口统计数据,诊断方法,ABO血型,和Rh血型是从医院记录中获得的。此外,数据来自自我报告的问卷,其中包括家族史,痛经,初潮年龄,生育年龄,儿童数量,流产史,奇偶校验,儿童数量,使用口服避孕药缓解痛经,缺铁,月经量的持续时间,和月经期间的出血量。赔率比,皮尔逊卡方检验(χ2),和独立t检验用于分析变量之间的关联。结果大多数参与者为O型血(n=117,51.3%),其次是A型血(n=59,26.0%),大多数为Rh+(n=215,94.3%)。根据ABO(P=0.237)和Rh(P=0.283)血型,子宫内膜异位症的风险没有显着差异。然而,发现子宫内膜异位症与痛经有显著关系,月经期间大量出血,流产史,月经持续时间长,儿童数量减少,妊娠晚期,和使用口服避孕药缓解痛经(p≤0.05)。结论目前的结果表明,ABO和Rh血型与子宫内膜异位症的风险无关。然而,有一个强大的,子宫内膜异位症和其他因素之间存在显著关联。
Background There is no sound evidence for the association of blood groups with the risk of endometriosis, and no studies from Saudi Arabia have examined this association. Therefore, the primary aim was to determine whether there is an association between the distribution of ABO and Rh blood groups and the incidence of endometriosis in a cohort from Saudi Arabia and also to evaluate the potential risk factors related to endometriosis among the population. Methods This
case-control study included women diagnosed with endometriosis (n = 44) who presented to King Abdulaziz University Hospital Obstetrics and Gynecology Clinic, Jeddah, Saudi Arabia, between 2010 and 2021. Women from the blood donors database of King Abdulaziz University Hospital were included as a control group (n = 184). The total sample size was 228. Demographic data, diagnosis method, ABO blood type, and Rh blood type were obtained from hospital records. In addition, data were collected from self-reported questionnaires, which included family history, dysmenorrhea, age of menarche, age of childbearing, number of children, history of abortion, parity, number of children, use of oral contraceptives for alleviating dysmenorrhea, iron deficiency, duration of menstrual flow, and volume of bleeding during menses. Odds ratio, Pearson chi-squared test (χ2), and independent t-test were used to analyze the associations between variables. Results Most of the participants had blood type O (n = 117, 51.3%), which was followed by blood type A (n = 59, 26.0%), and the majority were Rh+ (n = 215, 94.3%). There was no significant difference in the risk of endometriosis according to ABO (P = 0.237) and Rh (P = 0.283) blood types. However, endometriosis was found to have a significant relationship with dysmenorrhea, heavy bleeding during menses, history of abortion, long duration of menstrual flow, lower number of children, late pregnancy, and use of oral contraceptive pills to relieve dysmenorrhea (p ≤ 0.05). Conclusions The present results indicate that ABO and Rh blood types are not associated with the risk of endometriosis. However, there was a strong, significant association between endometriosis and other factors.