关于生活方式因素与手部湿疹之间关联的证据有限。广泛调查生活方式因素(吸烟,酒精消费,压力,身体活动,身体质量指数,饮食,和睡眠)和患病率,发病率,子类型,严重程度,手部湿疹的预后,根据流行病学中观察性研究的Meta分析共识声明进行系统评价和荟萃分析.MEDLINE,Embase,和WebofScience被搜索到2021年10月。(修改的)纽卡斯尔-渥太华量表用于判断偏倚风险。使用推荐等级对证据质量进行评级,评估,开发和评估方法。资格和质量由两名独立研究者盲目评估;分歧由第三名研究者解决。使用随机效应模型汇集数据,当荟萃分析不足时,证据是叙述性总结的。纳入了55项研究。荟萃分析(17项研究)发现,吸烟与较高的手部湿疹患病率相关的质量很低(比值比1.18,95%置信区间1.09-1.26)。没有令人信服的证据表明其他生活方式因素与手部湿疹有关,主要是由于异质性,冲突的结果,和/或每个结果的研究数量有限。
Evidence regarding the association between lifestyle factors and hand eczema is limited.To extensively investigate the association between lifestyle factors (smoking, alcohol consumption, stress, physical activity, body mass index, diet, and sleep) and the prevalence, incidence, subtype, severity, and prognosis of hand eczema, a systematic
review and meta-analysis were conducted in accordance with the Meta-analysis Of Observational Studies in Epidemiology consensus statement. MEDLINE, Embase, and Web of Science were searched up to October 2021. The (modified) Newcastle-Ottawa Scale was used to judge risk of bias. Quality of the evidence was rated using the Grades of Recommendation, Assessment, Development and Evaluation approach. Eligibility and quality were blindly assessed by two independent investigators; disagreements were resolved by a third investigator. Data were pooled using a random-effects model, and when insufficient for a meta-analysis, evidence was narratively summarized. Fifty-five studies were included. The meta-analysis (17 studies) found very low quality evidence that smoking is associated with a higher prevalence of hand eczema (odds ratio 1.18, 95% confidence interval 1.09-1.26). No convincing evidence of associations for the other lifestyle factors with hand eczema were found, mostly due to heterogeneity, conflicting results, and/or the limited number of studies per outcome.