2型糖尿病(T2DM)个体的胰岛素分泌受损,不足以适应外周组织的胰岛素抵抗(IR)。高瘦素血症反映了瘦素抵抗,这是T2DM患者产生IR的关键因素,使瘦素成为评估IR水平的潜在生物标志物。该研究的目的是评估T2DM患者血清瘦素和胰岛素水平的相关性。这项病例对照研究是针对T2DM患者进行的。根据美国糖尿病协会(ADA)标准,共纳入73例诊断为T2DM的患者(病例组)和40例健康参与者(对照组;第3组)。在案例组中,根据WHO标准,T2DM患者纳入代谢综合征(第1组,n=38)或无代谢综合征(第2组,n=35)。评估有或没有代谢综合征的T2DM患者的代谢谱,并将这两组与健康对照组进行比较。所有组的受试者年龄和性别匹配。身体质量指数(BMI,P<.01),空腹(P=0.0133)和餐后(P<0.01)血糖水平,%糖化血红蛋白(HbA1c,P<.01),与第2组和第3组相比,第1组的血脂谱(P<0.01)显着不同,并且更高。代谢综合征患者的血清瘦素和胰岛素水平较高,且具有统计学意义(两者均P<0.01)。血清瘦素水平为10.01±2.7ng/mL,6.9±2.4ng/mL,和4.11±1.8ng/mL,血清胰岛素120±40.7µIU/mL,20.43±5.2µIU/mL,第1、2和3组分别为11.4±2.5µIU/mL。BMI、血糖,HbA1c,血清胆固醇(TC),病例组甘油三酯(TG)与血清胰岛素和瘦素水平。病例组BMI与血清瘦素水平呈极显著相关(R=0.74,P<.001)。血清瘦素和胰岛素水平有正相关,血清瘦素是IR综合征的重要预测因子(证据水平:5;技术功效:第3阶段)。
Secretion of insulin is compromised in type 2 diabetes (T2DM) individuals and inadequate to accommodate for insulin resistance (IR) in peripheral tissue. Hyperleptinemia reflects leptin resistance, which is a key factor in the production of IR in T2DM patients, making leptin a potential biomarker for evaluating IR levels. The objective of the study was to assess the association of serum leptin and insulin levels among T2DM patients. This
case-control research was carried out on T2DM patients. A total of 73 patients diagnosed with T2DM (the
case group) and 40 healthy participants (control; group 3) were enrolled according to the American Diabetes Association (ADA) criteria. In the
case group, T2DM patients were enrolled with metabolic syndrome (group 1, n = 38) or without metabolic syndrome (group 2, n = 35) according to the WHO criteria. Metabolic profiles of T2DM patients with or without metabolic syndrome were evaluated, and compare these two groups with healthy controls. The subjects of all groups were age- and gender-matched. Body mass index (BMI, P < .01), fasting (P = .0133) and postprandial (P < .01) blood sugar levels, % glycated hemoglobin (HbA1c, P < .01), and lipid profile (P < .01) were found significantly different and higher in group 1 as compared to groups 2 and 3. Serum leptin and insulin levels were found higher and significant in patients with metabolic syndrome (P < .01 for both). The values of serum leptin levels were 10.01 ± 2.7 ng/mL, 6.9 ± 2.4 ng/mL, and 4.11 ± 1.8 ng/mL, and those of serum insulin 120 ± 40.7 µIU/mL, 20.43 ± 5.2 µIU/mL, and 11.4 ± 2.5 µIU/mL in groups 1, 2, and 3, respectively. There was a positive linear correlation between BMI, blood sugar, HbA1c, serum cholesterol (TC), and triglycerides (TG) with serum insulin and leptin levels in the
case group. An extremely significant correlation (R = 0.74, P < .001) was found in BMI and serum leptin level in the
case group. Serum leptin and insulin levels have a positive association, with serum leptin being a significant predictor of IR syndrome (Evidence Level: 5; Technical Efficacy: Stage 3).