在这项双盲安慰剂对照的随机调查中,我们评估了从3个日托中心招募的老年人对谷氨酰胺的耐受性.研究老年患者补充谷氨酰胺的相关性在于其提供良好耐受性干预的潜力。谷氨酰胺,一种关键的氨基酸,在各种生理过程中起着至关重要的作用,包括免疫功能和蛋白质合成。了解其对老年人的影响至关重要,考虑到对他们的健康和福祉的潜在影响。参与者每天接受12.4g口服泡腾谷氨酰胺(EGln组)或麦芽糖糊精(安慰剂组)60天。每组15名患者完成了研究。EGln组和安慰剂组的平均年龄分别为77.0±9.1和79.0±6.9岁,分别。我们评估了体重指数,氨基图,血象,血浆葡萄糖水平,前白蛋白,白蛋白,尿素,肌酐,尿酸,C反应蛋白,维生素D,钙,钠,钾,以及天冬氨酸转氨酶和丙氨酸转氨酶的血浆活性。值得注意的是,我们量化了一系列广泛的炎症标志物和生长因子,从而全面了解补充谷氨酰胺的潜在作用.结果表明,口服谷氨酰胺不会引起任何评估参数的显着变化,无不良反应报告.这一发现表明,本研究中使用的谷氨酰胺剂量具有良好的耐受性和安全性。这些信息有助于更广泛地了解谷氨酰胺补充剂,强调其安全性并支持其作为维持老年人健康的可行干预措施的潜力。
In this double-blind placebo-controlled randomized investigation, we assessed the tolerability of
glutamine in older adults recruited from three daycare centers. The relevance of studying
glutamine supplementation in elderly patients lies in its potential to provide a well-tolerated intervention.
Glutamine, a crucial amino acid, plays a vital role in various physiological processes, including immune function and protein synthesis. Understanding its impact on older adults is essential, given the potential implications for their health and well-being. Participants received a daily dose of 12.4 g of oral effervescent glutamine (EGln group) or maltodextrin (placebo group) for 60 days. Fifteen patients from each group completed the
study. The mean ages were 77.0±9.1 and 79.0±6.9 years for the EGln and placebo groups, respectively. We evaluated body mass index, aminogram, hemogram, plasma levels of glucose, prealbumin, albumin, urea, creatinine, uric acid, C-reactive protein, vitamin D, calcium, sodium, potassium, and the plasma activities of aspartate aminotransferase and alanine aminotransferase. Notably, we quantified a broad array of inflammatory markers and growth factors providing a holistic understanding of the potential effects of glutamine supplementation. The results demonstrated that oral glutamine did not induce significant changes in any evaluated parameters, and no adverse effects were reported. This finding suggested that the dosage of
glutamine used in this
study was well-tolerated and safe. This information contributes to the broader understanding of glutamine supplementation, emphasizing its safety and supporting its potential as a viable intervention for maintaining health in aging individuals.