未经证实:早期声门型(T1-2N0M0)鳞状细胞癌患者的最佳治疗策略仍不清楚。
UNASSIGNED:使用监测进行了基于人群的回顾性分析,流行病学,和结束结果(SEER)数据库。倾向评分匹配(PSM)用于平衡治疗臂,Cox回归分析用于确定生存的预后因素。Kaplan-Meier分析,对数秩测试,和竞争风险分析用于比较治疗方式之间的生存结果(手术与放射治疗)。
未经评估:在这项研究中的3,994名合格患者中,与放疗相比,手术与癌症特异性生存率(CSS)和总生存率(OS)改善相关(log-ranktest,P<0.05)。这种有利于手术的生存趋势在T1a中是一致的,良好/中等分化等级,男性,和所有年龄亚组。然而,在基线特征与PSM平衡后,手术组和放疗组的生存结局(CSS和OS)无显著差异.有趣的是,在≥70岁的患者中,手术与放疗相比,癌症相关死亡风险降低39%(风险比0.61;95%CI:0.43~0.87;P=0.006).然而,在年轻患者(年龄<70岁)中未观察到这种有利于手术的生存趋势,T分期亚组,男性或女性亚组,或任何病理级别的亚组。
UNASSIGNED:在接受手术或放疗的早期声门鳞状细胞癌患者中,在生存方面,没有足够的证据支持一种方法而不是另一种方法。然而,建议年龄≥70岁的患者进行手术,因为,在这个群体中,与放疗相比,它与生存结局改善相关.
UNASSIGNED: The optimal treatment strategy for patients with early glottic (T1-2N0M0) squamous cancer remains unclear.
UNASSIGNED: A retrospective population-based analysis was performed using the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to balance treatment arms, and Cox regression analysis was used to determine prognostic factors for survival. Kaplan-Meier analysis, log-rank tests, and competing risk analysis were used to compare survival outcomes between treatment modalities (surgery vs. radiotherapy).
UNASSIGNED: Among the 3,994 eligible patients in this
study, surgery was associated with improved cancer-specific survival (CSS) and overall survival (OS) compared with radiotherapy (log-rank test, P<0.05). This survival trend favoring surgery was consistent in the T1a, well/moderately differentiated grade, male, and all age subgroups. However, after the baseline characteristics were balanced with PSM, the survival outcomes (CSS and OS) did not differ significantly between the surgery and radiotherapy groups. Interestingly, surgery was associated with a 39% reduced risk of cancer-related death compared with radiotherapy in patients aged ≥70 years (hazard ratio 0.61; 95% CI: 0.43-0.87; P=0.006). However, this survival trend favoring surgery was not observed in younger patients (age <70 years), T stage subgroups, male or female subgroups, or in any of the pathological grade subgroups.
UNASSIGNED: In patients with early glottic squamous cell carcinoma undergoing surgery or radiotherapy, there is no sufficient evidence favoring one method over another in terms of survival. However, surgery is recommended in patients aged ≥70 years because, in this group, it was associated with improved survival outcomes compared with radiotherapy.