目的:了解岳阳市宫颈癌(CC)及癌前病变妇女人乳头瘤病毒(HPV)的发病及基因型分布。中国,制定CC的预防和控制策略。
方法:纳入2019年9月至2022年9月岳阳市7家医院就诊的3674例宫颈病变和宫颈癌患者。他们包括1910宫颈上皮内瘤变(CIN)I,718CINII,576CINII和470CC,分别。在各医院检验科采用Realtime-PCR检测上述患者的HPV基因分型。
结果:在3674例患者中,HPV总患病率为74.69%(95%CI73.28-76.09%)。高、低危型HPV的发病率分别为73.46%和7.21%,分别。HPV在CINI中的患病率,CINII,CINIII,侵入性CC(ICC)组为66.65%(1273/1910,95%CI64.53-68.77%),80.78%(580/718,95%CI77.89-83.67%),83.88%(483/576,95%CI80.84-86.87%),和86.81%(408/470,95%CI83.74-89.88%),分别。ICC中的前三种HPV亚型是HPV16、HPV52和HPV58。HPV16的患病率随着疾病严重程度的增加而增加,这种基因型占12.57%,20.89%,36.98%,和50.85%的CINI,CINII,CINIII,和国际刑事法院案件,分别(p<0.001)。单个HPV感染在宫颈病变中占主导地位,患病率为48.50%(95%CI46.89-50.12%)。HPV患病率因年龄而异,在国际刑事法院的女性中排名最高,CINI,CINII和CINIII年龄≥60岁,50-59岁,40-49岁,40-49年,分别。
结论:岳阳市宫颈病变患者的HPV患病率很高,HPV16、52、58、53和51是宫颈病变患者中最常见的五种HPV基因型。
To investigate the distribution of the incidence and
genotypes of human papillomavirus (HPV) among women with cervical cancer (CC) and precancerous cervical lesions in Yueyang City, China, to develop prevention and control strategies for CC.
A total of 3674 patients with cervical lesions and cervical cancer who attended 7 hospitals in Yueyang City between September 2019 and September 2022 were included. They included 1910 cervical intraepithelial neoplasia (CIN) I, 718 CIN II, 576 CIN II and 470 CC, respectively. The HPV genotyping of the above patients was detected by Real time-PCR in the laboratory department of each hospital.
The total HPV prevalence was 74.69% (95% CI 73.28-76.09%) in 3674 patients. The incidence of high- and low-risk HPV was 73.46% and 7.21%, respectively. The prevalence of HPV in CIN I, CIN II, CIN III, and invasive CC (ICC) groups was 66.65% (1273/1910, 95% CI 64.53-68.77%), 80.78% (580/718, 95% CI 77.89-83.67%), 83.88% (483/576, 95% CI 80.84-86.87%), and 86.81% (408/470, 95% CI 83.74-89.88%), respectively. The top three HPV subtypes in ICC are HPV16, HPV52, and HPV58. The prevalence of HPV 16 increased with increasing disease severity, with this genotype being present in 12.57%, 20.89%, 36.98%, and 50.85% of CIN I, CIN II, CIN III, and ICC cases, respectively (p < 0.001). Single HPV infection was predominant in cervical lesions, with a prevalence of 48.50% (95% CI 46.89-50.12%). The HPV prevalence varied by age, being highest among women with ICC, CIN I, CIN II and CIN III aged ≥ 60 years, 50-59 years, 40-49 years, and 40-49 years, respectively.
The prevalence of HPV in patients with cervical lesions in Yueyang City was very high, with HPV 16, 52, 58, 53, and 51 being the five most common HPV
genotypes in patients with cervical lesions.