海藻酸盐水凝胶通常用于伤口护理,因为它们能够保持潮湿的环境,吸收液体,并帮助伤口愈合。然而,它们的稳定性和机械性能有时会限制它们的有效性。这项研究探索了一种新的方法,通过在单个步骤中创建氧化的海藻酸盐和明胶水凝胶与聚多巴胺交联的双网络系统,目的是改善这些水凝胶的机械性能。这项研究的独特之处在于对双重交联系统中不同聚多巴胺浓度的全面检查。首先,藻酸盐用高碘酸钠改性,在其主链上产生额外的活性基团,然后测试各种聚多巴胺浓度以评估它们对双交联网络和水凝胶性质的影响。这项研究涉及一系列测试,包括FTIR,H-NMR,SEM,凝胶化时间,流变学,附着力,抗氧化活性,溶胀率,减肥,药物释放,和细胞活力。发现添加聚多巴胺可提高交联密度(0.859×109mol。cm-3)。此外,结果表明,性能的改善,如减少重量损失,增强抗氧化剂和粘合剂质量,和更好的机械性能(2240kPa)。然而,必须确定聚多巴胺的最佳浓度,以实现伤口敷料的最佳性能。过量的聚多巴胺会增加聚合物链之间的空间,导致交联密度和储能模量降低。然而,它还可以增加溶胀率,降解率,孔径,孔隙度,抗氧化活性,和多巴胺释放。因此,确定功能性水凝胶的最佳浓度是至关重要的。值得注意的是,含有0.5mg的水凝胶。mL-1聚多巴胺表现出出色的细胞活力(第三天为108%),溶胀能力(480%),储能模量(2240kPa),凝胶化时间(3分钟),抗氧化活性(42.27%),和皮肤粘附(11kPa),使其成为高级伤口管理的最佳选择。根据调查结果,强调的是,这种特殊的水凝胶的应用加速伤口愈合,伤口闭合和组织学研究表明。缩写。
Alginate hydrogels are commonly used in wound care due to their ability to maintain a moist environment, absorb fluids, and aid wound healing. However, their stability and mechanical properties can sometimes limit their effectiveness. This
study explores a new approach by creating a dual network system of oxidized alginate and
gelatin hydrogel crosslinked with polydopamine in a single step, with the goal of improving the mechanical properties of these hydrogels. The unique aspect of this research is the comprehensive examination of different polydopamine concentrations in dual crosslinking systems. First, alginate was modified with sodium periodate to create additional active groups on its backbone, and various polydopamine concentrations were then tested to assess their impact on the dual crosslinking network and hydrogel properties. The
study involved a range of tests, including FTIR, H-NMR, SEM, gelation time, rheology, adhesion, antioxidant activity, swelling ratio, weight loss, drug release, and cell viability. The addition of polydopamine was found to enhance the crosslinking density (0.859 × 109 mol.cm-3). Additionally, the results indicated improvements in properties such as reduced weight loss, enhanced antioxidant and adhesive qualities, and better mechanical properties (2240 kPa). However, the optimal concentration of polydopamine must be determined to achieve the best properties for a wound dressing. Excessive polydopamine can increase the space between polymer chains, leading to a reduction in crosslinking density and storage modulus. Nevertheless, it can also increase the swelling ratio, degradation rate, pore size, porosity, antioxidant activity, and dopamine release. Therefore, identifying the optimal concentration for a functional hydrogel is crucial. Notably, the hydrogel containing 0.5 mg.mL-1 polydopamine exhibited outstanding cell viability (108 % on the third day), swelling capacity (480 %), storage modulus (2240 kPa), gelation time (3 min), antioxidant activity (42.27 %), and skin adherence (11 kPa), making it an optimal choice for advanced wound management. According to the findings, it is emphasized that the application of this particular hydrogel expedites wound healing, as indicated by wound closure and histological studies. ABBREVIATIONS.